Origin of X-ray Spectral Variation and the Seemingly Broad Iron-Line Spectral Feature in Seyfert Galaxies

We present systematic X-ray data analysis of the Seyfert galaxies observed by Suzaku to study origin of their hard X-ray (2 - 40 keV) variations. In particular, we examine if the "Variable Partial Covering (VPC) model" proposed by Miyakawa, Ebisawa and Inoue (2012), which was successful to explain spectral variations of MCG{6-30-15, is also valid for other Seyfert galaxies or not. In this model, intrinsic X-ray luminosity of the AGN is not signicantly variable, and most observed flux and spectral variations are caused by change of the geometrical covering fraction of the extended X-ray source by ionized absorbing clouds in the line of sight. We found that the observed flux and spectral variations of 20 targets in addition to MCG{6-30-15 are successfully explained by the VPC model. The transmitted spectral component through the absorbing clouds has a characteristics spectral feature of the ionized iron K-edge, which is considered to be the origin of the seemingly broad iron-line feature commonly observed in Seyfert galaxies. Variation of the partial covering fraction of the constant X-ray luminosity source causes such an anti-correlation between the direct (non-obscured) component and the transmitted (obscured) component, that cancels their variations each other. The cancellation works most effectively at the energy band where intensities of the two components are the closest to each other, namely, just below the iron K-edge. This explains the signicantly small fractional variations in the iron K-energy band, another well-known observational characteristic of Seyfert galaxies

Thyroid storm associated with Graves' disease covered by diabetic ketoacidosis: A case report

<p>Abstract</p> <p>Background</p> <p>Thyroid storm is a condition in which multiple organ dysfunction results from failure of the compensatory mechanisms of the body owing to excessive thyroid hormone activity induced by some factors in patients with thyrotoxicosis. While diabetic ketoacidosis (DKA) is an important trigger for thyroid storm, simultaneous development of DKA and thyroid storm is rare.</p> <p>Case presentation</p> <p>A 59-year-old woman with no history of either diabetes mellitus or thyroid disease presented to our hospital because of developing nausea, vomiting and diarrhea for 2 days. Physical examination showed mild disturbance of consciousness, fever, and tachycardia. There were no other signs of thyrotoxicosis. Laboratory studies revealed elevation of random blood glucose and glycosylated hemoglobin, strongly positive of urine acetone, and metabolic acidosis. Since DKA was diagnosed, we initiated the patient on treatment with administration of insulin and adequate fluid replacement. Although the hyperglycemia and acidosis were immediately relieved, the disturbance of consciousness and tachycardia remained persistent. Levels of FT3 and FT4 were extremely high and TSH was below the detectable limit. TRAb was positive. The thyroid storm score of Burch & Wartofsky was 75/140, and the thyroid storm diagnostic criteria of the Japan Thyroid Association were satisfied. Oral administration of thiamazole, potassium iodide and propranolol resulted in immediate relief of the tachycardia.</p> <p>Discussion</p> <p>We encountered a case of thyroid storm associated with Graves' disease covered by DKA. Thyroid storm and DKA are both potentially fatal, and the prognosis varies depending on whether or not these conditions are detected and treated sufficiently early. The thyroid storm diagnostic criteria prepared in 2008 by the Japan Thyroid Association are very simple as compared to the Burch & Wartofsky scoring system for thyroid storm. The Japanese criteria may be useful in the diagnosis of this condition since they enable clinicians to identify a broad range of cases with thyroid storm. When dealing with cases of DKA or thyroid storm, it seems essential to bear in mind the possibility of the coexistence of these two diseases.</p

Effects of attentional bias modification on chronic low back pain in older outpatients

Objectives: In the present study, the effect of attentional bias modification (ABM) on older outpatients, with chronic low back pain, was examined.Design: This was a single-center, randomized, single-blinded, crossover trial and patients were randomly divided in a 1:1 allocation ratio into two groups: an ABM Leading group and an ABM Trailing group.Participants: Forty-three outpatients with chronic low back pain participated.Interventions: Patients were evaluated four times and the treatments were ABM + Normal intervention or Normal intervention only.Outcomes: Outcome measures included pain intensity on the Numerical Rating Scale, the Pain Catastrophizing Scale, Fear-Avoidance Beliefs Questionnaire, Hospital Anxiety and Depression Scale, Somatic Symptom Scale-8, and EuroQol 5 Dimension-3 levels questionnaire. In addition, we performed the 30-second Chair-Stand test and the Timed Up & Go test for physical function evaluations.Results: There was no change in pain intensity due to ABM. However, the total Pain Catastrophizing Scale score was significantly decreased, and the EuroQol 5 Dimension-3 levels questionnaire and 30-second chair-stand test were significantly improved (P <.05).Trial registration: The Health Science Ethics Committee, Graduate School of Biomedical Sciences, Nagasaki University (permit number: 17060861), and the clinical trial was registered with UMIN (UMIN000029424)

Excitability of the Primary Motor Cortex Increases More Strongly with Slow- than with Normal-Speed Presentation of Actions

Introduction: The aim of the present study was to investigate how the speed of observed action affects the excitability of the primary motor cortex (M1), as assessed by the size of motor evoked potentials (MEPs) induced by transcranial magnetic stimulation (TMS). Copyright:Methods: Eighteen healthy subjects watched a video clip of a person catching a ball, played at three different speeds (normal-, half-, and quarter-speed). MEPs were induced by TMS when the model\u27s hand had opened to the widest extent just before catching the ball ("open") and when the model had just caught the ball ("catch"). These two events were locked to specific frames of the video clip ("phases"), rather than occurring at specific absolute times, so that they could easily be compared across different speeds. MEPs were recorded from the thenar (TH) and abductor digiti minimi (ADM) muscles of the right hand.Results: The MEP amplitudes were higher when the subjects watched the video clip at low speed than when they watched the clip at normal speed. A repeated-measures ANOVA, with the factor VIDEO-SPEED, showed significant main effects. Bonferroni\u27s post hoc test showed that the following MEP amplitude differences were significant: TH, normal vs. quarter; ADM, normal vs. half; and ADM, normal vs. quarter. Paired t-tests showed that the significant MEP amplitude differences between TMS phases under each speed condition were TH, "catch" higher than "open" at quarter speed; ADM, "catch" higher than "open" at half speed.Conclusions: These results indicate that the excitability of M1 was higher when the observed action was played at low speed. Our findings suggest that the action observation system became more active when the subjects observed the video clip at low speed, because the subjects could then recognize the elements of action and intention in others

Changes in Cerebral Hemodynamics during Complex Motor Learning by Character Entry into Touch-Screen Terminals

Introduction Studies of cerebral hemodynamics during motor learning have mostly focused on neurorehabilitation interventions and their effectiveness. However, only a few imaging studies of motor learning and the underlying complex cognitive processes have been performed. Methods We measured cerebral hemodynamics using near-infrared spectroscopy (NIRS) in relation to acquisition patterns of motor skills in healthy subjects using character entry into a touchscreen terminal. Twenty healthy, right-handed subjects who had no previous experience with character entry using a touch-screen terminal participated in this study. They were asked to enter the characters of a randomly formed Japanese syllabary into the touchscreen terminal. All subjects performed the task with their right thumb for 15 s alternating with 25 s of rest for 30 repetitions. Performance was calculated by subtracting the number of incorrect answers from the number of correct answers, and gains in motor skills were evaluated according to the changes in performance across cycles. Behavioral and oxygenated hemoglobin concentration changes across task cycles were analyzed using Spearman\u27s rank correlations. Results Performance correlated positively with task cycle, thus confirming motor learning. Hemodynamic activation over the left sensorimotor cortex (SMC) showed a positive correlation with task cycle, whereas activations over the right prefrontal cortex (PFC) and supplementary motor area (SMA) showed negative correlations. Conclusions We suggest that increases in finger momentum with motor learning are reflected in the activity of the left SMC. We further speculate that the right PFC and SMA were activated during the early phases of motor learning, and that this activity was attenuated with learning progress

La culture légitime et la distinction dans le Japon contemporain

Cet article s’interroge sur la pertinence d’une approche en termes de “culture légitime” dans le cas japonais, qui serait au fondement de la distinction sociale. Il part de la théorisation de Pierre Bourdieu entendant rompre avec le relativisme et le principe d’autonomie des cultures pour mettre l’accent sur les rapports entre classes sociales et la domination des couches supérieures. Toutefois, il est montré en quoi l’application du modèle se révèle assez délicate au Japon, la question se posant de savoir dans quelle mesure ce sont surtout des codes “traditionnels” ou des pratiques importées (à commencer par les concerts de musique classique occidentale) qui structurent la distinction. S’appuyant sur des enquêtes menées en 1995 et en 2015 autour de la stratification, la mobilité sociale et la conscience de classe, ce travail conclut qu’il y a bien des codes dominants mais que ceux-ci sont relativement contradictoires, rendant complexe la mise en œuvre d’une analyse en termes de “culture légitime”. Seules des recherches très approfondies pourraient permettre d’éclairer sa composition.This article questions the relevance, in the Japanese case, of an approach in terms of a “legitimate culture” which would be at the basis of social distinction. It begins with Pierre Bourdieu’s theorization intending to break with the relativism and principle of autonomy of cultures in placing the accent on the relationships between social classes and the upper classes’ domination. Yet we are shown why applying the model turns out to be rather delicate in Japan, the question arising of knowing the extent to which they are essentially “traditional” codes or imported practices (in beginning with Western classical music concerts) which structure distinction. Relying on surveys carried out in 1995 and 2015 involving stratification, social mobility and class consciousness, this work concludes that there are indeed dominant codes but that they are relatively contradictory, making the implementation of an analysis in terms of “legitimate culture” rather complex. Only very thorough research work would allow us to clarify its composition