Cost-Efficient Storage for On-Demand Video Streaming on Cloud

Video stream is converted to several formats to support the user's device, this conversion process is called video transcoding, which imposes high storage and powerful resources. With emerging of cloud technology, video stream companies adopted to process video on the cloud. Generally, many formats of the same video are made (pre-transcoded) and streamed to the adequate user's device. However, pre-transcoding demands huge storage space and incurs a high-cost to the video stream companies. More importantly, the pre-transcoding of video streams could be hierarchy carried out through different storage types in the cloud. To minimize the storage cost, in this paper, we propose a method to store video streams in the hierarchical storage of the cloud. Particularly, we develop a method to decide which video stream should be pre-transcoded in its suitable cloud storage to minimize the overall cost. Experimental simulation and results show the effectiveness of our approach, specifically, when the percentage of frequently accessed videos is high in repositories, the proposed approach minimizes the overall cost by up to 40 percent.Comment: International IEEE World Forum for Internet of Thing

Detection of HER-2/neu, c-myc amplification and p53 inactivation by FISH in Egyptian patients with breast cancer

Breast cancer is a leading cause of cancer-related deaths in women worldwide. The clinical course of this disease is highly variable and clinicians continuously search for prognostic parameters that can accurately predict prognosis, and indicate a suitable adjuvant therapy for each patient. Amplification of the two oncogenes HER-2/neu and c-myc and inactivation of the tumor suppressor gene p53 are frequently encountered in breast carcinomas. The purpose of this study was to use the fluorescence in situ hybridization (FISH) for the assessment of HER-2/neu and c-myc amplification and p53 inactivation and to relate these molecular markers with the commonly used clinical and pathological factors. The study was conducted on 34 tissue samples obtained from 33 females and 1 male with breast carcinomas and 17 samples obtained from 16 females and 1 male with benign breast lesions. Results revealed that the level of HER-2/neu, c-myc and p53 in the malignant group was significantly increased as compared to the benign group. On relating the level of the molecular markers to clinicopathological factors, p53 was significantly associated with increased patient’s age. The sensitivity of the investigated markers significantly increased with larger tumor size. Concerning tumor grade, HER-2/neu and p53 showed a significant increase in low-grade tumors whereas c-myc showed a highly significant increase in high-grade tumors. With regard to disease staging, HER-2/neu and c-myc were the only markers that showed significant increase at late stages of disease. p53 and HER-2/neu were significantly associated with positive lymph nodal status. A significant correlation was obtained between the levels of the three biomarkers to each other. Conclusively, the combination of HER-2/neu, c-myc and p53 can stratify patients into different risk groups

Anxiety and Depression among Family Caregivers of Older Adults with Cancer

Anxiety and depression are the most common problems experienced by family caregivers. Aim: to assess anxiety and depression among family caregivers of older adults with cancer. Method: descriptive research design was used in this study. The study carried out on 157 family caregivers of the older adults diagnosed with cancer attending Mansoura Oncology Center within a period of three months. Data was collected using four tools, Socio demographic and clinical data structured interview schedule, Barthel Index Scale, Lawton and Brody Scale and Hospital Anxiety and Depression Scale. Results: the mean scores of anxiety were 11.31±3.37 in which the prevalence of anxiety among caregivers was 85.3%. The mean scores of depression were 10.64±3.22 in which the prevalence of depression was 81.5%. Conclusion: Family caregivers of older adults with cancer experienced high levels of anxiety and depression. Keywords: Older adults, Cancer, Anxiety, Depression, Family caregiver

BIOLOGICAL CONTROL OF SOIL -BORNE FUNGAL PATHOGENS

Seventeen bacterial isolates have been successfully isolated and purified from soil rhizosphere samples collected from different agricultural areas Buhayra, Sharqia and Alqilyubia of Egypt, and screened for production of chitinase enzymes had the highest chitinolytic activities amongst those investigated. Isolate S3-C and S1-C were Identified by biochemical, physiological tests and 16s rRNA gene primer as Bacillus cereus S3C, Gene Bank NCBI accession MK185696 and Bacillus cereus S1C accession MK185697. The production of chitinase by B.cereus S3C and Bacillus cereus S1C was optimized using colloidal chitin medium amended with 1% colloidal chitin at 30°C after five days of incubation. B.cereus S3C had potential for cell wall lysis of many phytopathogenic fungi tested such as Fusarium oxysporum and Rhizoctonia solani Potato phytopathogenic fungi by in vitro antagonistic test. The addition of B. cereus S3C chitinase was more effective than that of B.cereus S1C in increasing the resistance of Potato plants infected with various Soil- borne phytopathogenic fungi

Synthesis and biological evaluation of phthalimide dithiocarbamate and dithioate derivatives as anti-proliferative and anti-angiogenic agents-I

A facile synthesis of new phthalimide dithiocarbamate and dithioate analogs 8a-j, 9a-e and 9g-j were achieved by the reaction of N-chloromethyl and N-bromoethylphthalimide with carbon disulfide (CS2) and various amines. The structures of the synthesized analogs were elucidated by spectroscopic methods, including IR, 1H NMR and 13C NMR, and ESI-HRMS techniques. The antiproliferative activity of the newly synthesized compounds was also evaluated against various human cancer cell lines. The compound 9e and 9i exhibited the highest activity against human breast adenocarcinoma MCF-7 and hepatocellular carcinoma HepG2 cells. Compound 8f showed better antiproliferative effect against colon carcinoma HCT-116 and cervical carcinoma HeLa compared to thalidomide. The binding affinity to vascular endothelial growth factor receptor (VEGFR) of some compounds was assessed in addition to molecular docking study. Compounds 9e and 9i showed high docking score values and they significantly declined the concentration of VEGFR

Inconsistency in historical simulations and future projections of temperature and rainfall: A comparison of CMIP5 and CMIP6 models over Southeast Asia

The objective of this research was to assess the difference in historical simulations and future projections of rainfall and temperature of CMIP5 (RCP4.5 and 8.5) and CMIP6 (SSP2–4.5 and 5–8.5) models over Southeast Asia (SEA). Monthly historical rainfall and temperature estimations of 13 global climate models common to both CMIPs were evaluated to assess their capability to reproduce the spatial distribution and seasonality of European Reanalysis (ERA) rainfall and temperature. Models were used to determine uncertainty with spatiotemporal variability of rainfall and temperature projections. The CMIP6 GCMs did not appear to perform better than the older CMIP5 in SEA unlike other parts of the globe, except for rainfall. The CMIP6 models showed Kling-Gupta Efficiency (KGE) values in the range of -0.48-0.6, 0.21-0.85 and 0.66-0.91 in simulating historical rainfall, maximum temperature and minimum temperature compared to 0.13-0.46, 0.3-0.86 and 0.42-0.92 for CMIP5. The improvement in CMIP6 models in SEA was in the low uncertainty in ensemble simulation. The projections of CMIP5 and CMIP6 showed a relatively smaller increase in temperature with the CMIP6 ensemble when compared to CMIP5 models, while rainfall appeared to decrease. The geographical distribution of the changes indicated a greater increase in temperature in the cooler region than in the warmer region. In contrast, there was increase in rainfall in the wetter region and a smaller improvement in the drier region. This indicates increased homogeneity in temperature spatial variability, but more heterogeneity in rainfall, in the SEA region under climate warming scenarios