436 research outputs found
Building Morphological Chains for Agglutinative Languages
In this paper, we build morphological chains for agglutinative languages by
using a log-linear model for the morphological segmentation task. The model is
based on the unsupervised morphological segmentation system called
MorphoChains. We extend MorphoChains log linear model by expanding the
candidate space recursively to cover more split points for agglutinative
languages such as Turkish, whereas in the original model candidates are
generated by considering only binary segmentation of each word. The results
show that we improve the state-of-art Turkish scores by 12% having a F-measure
of 72% and we improve the English scores by 3% having a F-measure of 74%.
Eventually, the system outperforms both MorphoChains and other well-known
unsupervised morphological segmentation systems. The results indicate that
candidate generation plays an important role in such an unsupervised log-linear
model that is learned using contrastive estimation with negative samples.Comment: 10 pages, accepted and presented at the CICLing 2017 (18th
International Conference on Intelligent Text Processing and Computational
Linguistics
A semi-parametric approach to estimate risk functions associated with multi-dimensional exposure profiles: application to smoking and lung cancer
A common characteristic of environmental epidemiology is the multi-dimensional aspect of exposure patterns, frequently reduced to a cumulative exposure for simplicity of analysis. By adopting a flexible Bayesian clustering approach, we explore the risk function linking exposure history to disease. This approach is applied here to study the relationship between different smoking characteristics and lung cancer in the framework of a population based case control study
Random survival forests
We introduce random survival forests, a random forests method for the
analysis of right-censored survival data. New survival splitting rules for
growing survival trees are introduced, as is a new missing data algorithm for
imputing missing data. A conservation-of-events principle for survival forests
is introduced and used to define ensemble mortality, a simple interpretable
measure of mortality that can be used as a predicted outcome. Several
illustrative examples are given, including a case study of the prognostic
implications of body mass for individuals with coronary artery disease.
Computations for all examples were implemented using the freely available
R-software package, randomSurvivalForest.Comment: Published in at http://dx.doi.org/10.1214/08-AOAS169 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
A Recurrent Neural Network Survival Model: Predicting Web User Return Time
The size of a website's active user base directly affects its value. Thus, it
is important to monitor and influence a user's likelihood to return to a site.
Essential to this is predicting when a user will return. Current state of the
art approaches to solve this problem come in two flavors: (1) Recurrent Neural
Network (RNN) based solutions and (2) survival analysis methods. We observe
that both techniques are severely limited when applied to this problem.
Survival models can only incorporate aggregate representations of users instead
of automatically learning a representation directly from a raw time series of
user actions. RNNs can automatically learn features, but can not be directly
trained with examples of non-returning users who have no target value for their
return time. We develop a novel RNN survival model that removes the limitations
of the state of the art methods. We demonstrate that this model can
successfully be applied to return time prediction on a large e-commerce dataset
with a superior ability to discriminate between returning and non-returning
users than either method applied in isolation.Comment: Accepted into ECML PKDD 2018; 8 figures and 1 tabl
Siamese Survival Analysis with Competing Risks
Survival analysis in the presence of multiple possible adverse events, i.e.,
competing risks, is a pervasive problem in many industries (healthcare,
finance, etc.). Since only one event is typically observed, the incidence of an
event of interest is often obscured by other related competing events. This
nonidentifiability, or inability to estimate true cause-specific survival
curves from empirical data, further complicates competing risk survival
analysis. We introduce Siamese Survival Prognosis Network (SSPN), a novel deep
learning architecture for estimating personalized risk scores in the presence
of competing risks. SSPN circumvents the nonidentifiability problem by avoiding
the estimation of cause-specific survival curves and instead determines
pairwise concordant time-dependent risks, where longer event times are assigned
lower risks. Furthermore, SSPN is able to directly optimize an approximation to
the C-discrimination index, rather than relying on well-known metrics which are
unable to capture the unique requirements of survival analysis with competing
risks
Location Dependent Dirichlet Processes
Dirichlet processes (DP) are widely applied in Bayesian nonparametric
modeling. However, in their basic form they do not directly integrate
dependency information among data arising from space and time. In this paper,
we propose location dependent Dirichlet processes (LDDP) which incorporate
nonparametric Gaussian processes in the DP modeling framework to model such
dependencies. We develop the LDDP in the context of mixture modeling, and
develop a mean field variational inference algorithm for this mixture model.
The effectiveness of the proposed modeling framework is shown on an image
segmentation task
The dynamics of E1A in regulating networks and canonical pathways in quiescent cells
<p>Abstract</p> <p>Background</p> <p>Adenoviruses force quiescent cells to re-enter the cell cycle to replicate their DNA, and for the most part, this is accomplished after they express the E1A protein immediately after infection. In this context, E1A is believed to inactivate cellular proteins (e.g., p130) that are known to be involved in the silencing of E2F-dependent genes that are required for cell cycle entry. However, the potential perturbation of these types of genes by E1A relative to their functions in regulatory networks and canonical pathways remains poorly understood.</p> <p>Findings</p> <p>We have used DNA microarrays analyzed with Bayesian ANOVA for microarray (BAM) to assess changes in gene expression after E1A alone was introduced into quiescent cells from a regulated promoter. Approximately 2,401 genes were significantly modulated by E1A, and of these, 385 and 1033 met the criteria for generating networks and functional and canonical pathway analysis respectively, as determined by using Ingenuity Pathway Analysis software. After focusing on the highest-ranking cellular processes and regulatory networks that were responsive to E1A in quiescent cells, we observed that many of the up-regulated genes were associated with DNA replication, the cell cycle and cellular compromise. We also identified a cadre of up regulated genes with no previous connection to E1A; including genes that encode components of global DNA repair systems and DNA damage checkpoints. Among the down-regulated genes, we found that many were involved in cell signalling, cell movement, and cellular proliferation. Remarkably, a subset of these was also associated with p53-independent apoptosis, and the putative suppression of this pathway may be necessary in the viral life cycle until sufficient progeny have been produced.</p> <p>Conclusions</p> <p>These studies have identified for the first time a large number of genes that are relevant to E1A's activities in promoting quiescent cells to re-enter the cell cycle in order to create an optimum environment for adenoviral replication.</p
Overcoming data scarcity of Twitter: using tweets as bootstrap with application to autism-related topic content analysis
Notwithstanding recent work which has demonstrated the potential of using
Twitter messages for content-specific data mining and analysis, the depth of
such analysis is inherently limited by the scarcity of data imposed by the 140
character tweet limit. In this paper we describe a novel approach for targeted
knowledge exploration which uses tweet content analysis as a preliminary step.
This step is used to bootstrap more sophisticated data collection from directly
related but much richer content sources. In particular we demonstrate that
valuable information can be collected by following URLs included in tweets. We
automatically extract content from the corresponding web pages and treating
each web page as a document linked to the original tweet show how a temporal
topic model based on a hierarchical Dirichlet process can be used to track the
evolution of a complex topic structure of a Twitter community. Using
autism-related tweets we demonstrate that our method is capable of capturing a
much more meaningful picture of information exchange than user-chosen hashtags.Comment: IEEE/ACM International Conference on Advances in Social Networks
Analysis and Mining, 201
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