Solitary Fibrous Tumor of the Thigh: A Patient Report

We report a rare case of solitary fibrous tumor (SFT) within the thigh muscle. A 37-year-old woman noticed a painless mass in her left thigh, which had gradually enlarged. Computed tomography (CT) showed an intramuscular tumor and enhanced CT showed strong enhancement within the lesion. Magnetic resonance imaging revealed that the tumor measured 13.1 × 7.3 × 2.3 cm and was located within the sartorius muscle, with a clearly defined margin. Malignancy was suspected and the tumor was surgically resected. The tumor was characterized by a well-circumscribed lesion, and was composed of bland or short spindle cells, which were patternless, with scattered thick collagen bundles, and variably gaping thin- or hyalin-walled blood vessels. Immunohistochemically, the tumor cells were positive for vimentin, CD34, CD99 and focally, bcl-2. The tumor was subsequently diagnosed as an extrapleural SFT, which is classified into an intermediated (rarely metastasizing) category. Extrapleural SFT should be considered in the evaluation of soft tissue tumors in the extremities, although it may be rare

Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: Possible association with malignancy

Objectives: Myositis-specific autoantibodies (MSAs) are useful tools for identifying clinically homogeneous subsets and predicting prognosis of patients with idiopathic inflammatory myopathies (IIM) including polymyositis (PM) and dermatomyositis (DM). Recent studies have shown that anti-NXP2 antibody (Ab) is a major MSA in juvenile dermatomyositis (JDM). In this study the frequencies and clinical associations of anti-NXP2 Ab were evaluated in adult patients with IIM. Methods: Clinical data and serum samples were collected from 507 adult Japanese patients with IIM (445 with DM and 62 with PM). Eleven patients with JDM, 108 with systemic lupus erythematosus, 433 with systemic sclerosis and 124 with idiopathic pulmonary fibrosis were assessed as disease controls. Serum was examined for anti-NXP2 Ab by immunoprecipitation and western blotting using polyclonal anti-NXP2 Ab. Results: Seven patients (1.6%) with adult DM and one (1.6%) with adult PM were positive for anti-NXP2 Ab. Except for two patients with JDM, none of the disease controls were positive for this autoantibody. Among eight adult patients with IIM, three had internal malignancies within 3 years of diagnosis of IIM. Another patient with DM also had a metastatic cancer at the diagnosis. All of the carcinomas were at an advanced stage (stage IIIb-IV). Conclusions: While less common than in juvenile IIM, anti-NXP2 Ab was found in adult IIM. Anti-NXP2 Ab may be associated with adult IIM with malignancy

教師の対人ストレス対処方略に関する臨床心理学的研究(4) ― 児童・生徒との関係におけるストレスと対処方略の類型化の試み ―

This study examined teachers\u27 cognitive framework for interpersonal stress caused by students and their coping strategies by using free-writing questionnaire method. Students whom teachers felt to be stressful were classified into four types. It showed that the more aggressive students were the more anger and depressive feeling teachers felt. It is suggested that each type is deeply connected with teachers\u27 "demand for maintenance of the norm" and that the viewpoint "whether students obey the norm or not" works strongly as the teachers\u27 cognitive framework. Furthermore, the inner and outer demand for maintenance of norms may make teachers more nervous and could be a background factor for their stress. Coping strategies are classified into four categories, among them "consultation" strategy was most frequently used and consultation for emotional support indicated high effectiveness. Establishing collaborative relationship among teachers, separating cognition of student\u27s misbehavior from teacher\u27s feelings, and flexibly reconstructing the cognitive framework into a new one on the basis of understanding student behavior was found to be very effective in the process for relating to students and decreasing stress. Further research from this standpoint can explore the collegial relationship as a support resource and method for augmenting teachers\u27 ability

On the origin and evolution of the asteroid Ryugu: A comprehensive geochemical perspective

Presented here are the observations and interpretations from a comprehensive analysis of 16 representative particles returned from the C-type asteroid Ryugu by the Hayabusa2 mission. On average Ryugu particles consist of 50% phyllosilicate matrix, 41% porosity and 9% minor phases, including organic matter. The abundances of 70 elements from the particles are in close agreement with those of CI chondrites. Bulk Ryugu particles show higher δ18O, Δ17O, and ε54Cr values than CI chondrites. As such, Ryugu sampled the most primitive and least-thermally processed protosolar nebula reservoirs. Such a finding is consistent with multi-scale H-C-N isotopic compositions that are compatible with an origin for Ryugu organic matter within both the protosolar nebula and the interstellar medium. The analytical data obtained here, suggests that complex soluble organic matter formed during aqueous alteration on the Ryugu progenitor planetesimal (several 10’s of km), <2.6 Myr after CAI formation. Subsequently, the Ryugu progenitor planetesimal was fragmented and evolved into the current asteroid Ryugu through sublimation

A pristine record of outer Solar System materials from asteroid Ryugu’s returned sample

Volatile and organic-rich C-type asteroids may have been one of the main sources of Earth’s water. Our best insight into their chemistry is currently provided by carbonaceous chondritic meteorites, but the meteorite record is biased: only the strongest types survive atmospheric entry and are then modified by interaction with the terrestrial environment. Here we present the results of a detailed bulk and microanalytical study of pristine Ryugu particles, brought to Earth by the Hayabusa2 spacecraft. Ryugu particles display a close compositional match with the chemically unfractionated, but aqueously altered, CI (Ivuna-type) chondrites, which are widely used as a proxy for the bulk Solar System composition. The sample shows an intricate spatial relationship between aliphatic-rich organics and phyllosilicates and indicates maximum temperatures of ~30 °C during aqueous alteration. We find that heavy hydrogen and nitrogen abundances are consistent with an outer Solar System origin. Ryugu particles are the most uncontaminated and unfractionated extraterrestrial materials studied so far, and provide the best available match to the bulk Solar System composition