"That Shakespearian Rome! Work in Progress..." An Experiment in Intermedial Criticism

Il saggio tratta una sperimentazione di critica shakespeareana intermediale, presentata durante il convegno internazionale Shakespeare and Rome: Identity, Otherness, Empire (Università di Roma Tre, Rome, Italy, 2005). Il saggio descrive e discute i modi in cui il video interrogava, attraverso accorgimenti tecnici quali, per esempio, alternazione, sovrapposizione e sincronia, per combinare materiale provenienti da una vasta varietà di generi multimediali, la Roma di Shakespeare cinquecento anni dopo nei nostri tempi postmoderni e postcoloniali e multiculturali

Brief Cognitive Screening Tools for Primary Care Practice

Early detection and diagnosis of Alzheimer’s disease and other cognitive impairment presents as a critical issue facing primary and specialty care providers in Washington State. In order to address the gaps and challenges faced by providers, the Dementia Action Collaborative offers the current paper to provide information and guidance around early detection and diagnosis of memory loss and dementia, including Alzheimer’s disease. At the conclusion of this paper, providers should be able to identify indications and opportunities for detection, appropriate tools, and care pathways for individuals and families affected by cognitive impairment and dementia

The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin

Previously we reported that the variable heavy chain region (V(H)) of a human beta(2 )glycoprotein I-dependent monoclonal antiphospholipid antibody (IS4) was dominant in conferring the ability to bind cardiolipin (CL). In contrast, the identity of the paired variable light chain region (V(L)) determined the strength of CL binding. In the present study, we examine the importance of specific arginine residues in IS4V(H )and paired V(L )in CL binding. The distribution of arginine residues in complementarity determining regions (CDRs) of V(H )and V(L )sequences was altered by site-directed mutagenesis or by CDR exchange. Ten different 2a2 germline gene-derived V(L )sequences were expressed with IS4V(H )and the V(H )of an anti-dsDNA antibody, B3. Six variants of IS4V(H), containing different patterns of arginine residues in CDR3, were paired with B3V(L )and IS4V(L). The ability of the 32 expressed heavy chain/light chain combinations to bind CL was determined by ELISA. Of four arginine residues in IS4V(H )CDR3 substituted to serines, two residues at positions 100 and 100 g had a major influence on the strength of CL binding while the two residues at positions 96 and 97 had no effect. In CDR exchange studies, V(L )containing B3V(L )CDR1 were associated with elevated CL binding, which was reduced significantly by substitution of a CDR1 arginine residue at position 27a with serine. In contrast, arginine residues in V(L )CDR2 or V(L )CDR3 did not enhance CL binding, and in one case may have contributed to inhibition of this binding. Subsets of arginine residues at specific locations in the CDRs of heavy chains and light chains of pathogenic antiphospholipid antibodies are important in determining their ability to bind CL

Predictors of quality and meaning in life in independently living older adults: A quantitative replication of Weinstock and Bond (2018)

In their in depth qualitative study of older adults living in a continuing care facility, Weinstock and Bond (2018) identified three first-order components of quality of life: (1) Sense of community and belonging, (2) resident driven engagement, and (3) individual autonomy, independence, and respect. Our present study attempts to replicate the Weinstock and Bond findings using a quantitative methodology in a sample of independent living residents in Bayview, a retirement community in Seattle. (n = 56, 36 females, 19 males, 1 gender non-conforming, ages 66 — 97 years). Early analyses indicate that only the third component (i.e., autonomy, independence, and respect) is a significant predictor of positive aging outcomes, including meaning in life. Various explanations for this divergence in findings are currently being explored

Images of aging and positive affect in independently living older adults: An update

The World Health Organization (2018) estimates that between 2015 and 2050, the proportion of the world\u27s older adult population will nearly double from 12% to 22%. Despite this increasing prevalence, negative age-related stereotypes persist, cross national and cultural boundaries, and are associated with poor cognitive, mental, and physical health. In contrast, older adults with more positive views of aging experience better mental and physical health, engage in more preventive healthy behaviors, and enjoy greater longevity. These positive aging outcomes are again confirmed in this year\u27s expanded study of independent living residents in Bayview, a retirement community in Seattle. (n = 56, 36 females, 19 males, 1 gender non-conforming, ages 66 — 97 years). In addition, this study explores possible mediation effects of social relationships, perceived health status, and age on the relationship between images of aging and positive affect

Alzheimer’s Disease and Other Dementias Workgroup: Alzheimer’s Disease and Other Dementias Report and Recommendations

Rates of Alzheimer’s disease and other dementias are expected to increase greatly over the next decades. Many practices lack guidelines on how to increase quality of diagnosing, treating, and supporting people with dementia and their family members and other caregivers. This workgroup met from January to November 2017, aligned with and built off the Alzheimer’s State Plan, and organized recommendations with the following focus areas: Early detection and appropriate diagnosis Ongoing care and support or management including for family members and caregivers Advance care planning and palliative care Assessment and planning for need for increased support and/or higher levels of care Preparing for potential hospitalization Screening for delirium risk during hospitalization for all patients over 6

Images of aging, well-being, and life satisfaction among independently living older adults

The U.S. is an aging country in an aging world, and yet negative age-related stereotypes abound and continue among the most institutionalized of isms. Such stereotypes in older adults are associated with poor mental and physical health. In contrast, older adults with more positive views of aging experience better mental and physical health, engage in more preventive healthy behaviors, and enjoy greater longevity. These positive aging outcomes are confirmed in the present study of independent living residents in Bayview, a retirement community in Seattle (n=41; 26 females, 14 males; ages 70-94 years). In addition, this study reports findings on such variables as perceptions of well-being, self-efficacy, social engagement, and spiritual expression. (Word count: 112