9 research outputs found

    フランスの音楽家に求められる資質と能力―DUMISTE のカリキュラム及び養成内容の実例から―

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     本研究では,フランスの「DUMI(デュミ)」という教育職の公務員として学校において音楽を教えることのできる音楽家のための国家資格について,そのカリキュラム並びに研修内容を述べる。筆頭筆者はフランスにおいて本資格を取得しており,資格取得に関する研修,試験内容はその体験から得られた具体的な実態を詳らかにするものである。 はじめにDUMI の概要を説明し,次に養成センターへの入学試験内容,カリキュラムを紹介する。そして,授業並びに実地研修の事例からDUMI の養成内容の特徴を明らかにする。それらからフランスの音楽家に求められる資質と能力について考察した。そこから,音楽家には演奏能力だけではなく,DUMI が求めるように,音楽を通して創造性を持った人間形成を促すような資質や能力も重視されるのではないかと考えられた

    Carbon Monoxide-Loaded Red Blood Cell Prevents the Onset of Cisplatin-Induced Acute Kidney Injury

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    Cisplatin-induced acute kidney injury (AKI) is an important factor that limits the clinical use of this drug for the treatment of malignancies. Oxidative stress and inflammation are considered to be the main causes of not only cisplatin-induced death of cancer cells but also cisplatin-induced AKI. Therefore, developing agents that exert antioxidant and anti-inflammatory effects without weakening the anti-tumor effects of cisplatin is highly desirable. Carbon monoxide (CO) has recently attracted interest due to its antioxidant, anti-inflammatory, and anti-tumor properties. Herein, we report that CO-loaded red blood cell (CO-RBC) exerts renoprotective effects on cisplatin-induced AKI. Cisplatin treatment was found to reduce cell viability in proximal tubular cells via oxidative stress and inflammation. Cisplatin-induced cytotoxicity, however, was suppressed by the CO-RBC treatment. The intraperitoneal administration of cisplatin caused an elevation in the blood urea nitrogen and serum creatinine levels. The administration of CO-RBC significantly suppressed these elevations. Furthermore, the administration of CO-RBC also reduced the deterioration of renal histology and tubular cell injury through its antioxidant and anti-inflammatory effects in cisplatin-induced AKI mice. Thus, our data suggest that CO-RBC has the potential to substantially prevent the onset of cisplatin-induced AKI, which, in turn, may improve the usefulness of cisplatin-based chemotherapy
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