Investigation of remote sensing techniques as inputs to operational resource management

The author has identified the following significant results. Visual interpretation of 1:125,000 color LANDSAT prints produced timely level 1 maps of accuracies in excess of 80% for agricultural land identification. Accurate classification of agricultural land via digital analysis of LANDSAT CCT's required precise timing of the date of data collection with mid to late June optimum for western South Dakota. The LANDSAT repetitive nine day cycle over the state allowed the surface areas of stockdams and small reservoir systems to be monitored to provide a timely approximation of surface water conditions on the range. Combined use of DIRS, K-class, and LANDSAT CCT's demonstrated the ability to produce aspen maps of greater detail and timeliness than was available using US Forest Service maps. Visual temporal analyses of LANDSAT imagery improved highway map drainage information and were used to prepare a seven county drainage network. An optimum map of flood-prone areas was developed, utilizing high altitude aerial photography and USGS maps

Investigation of remote sensing techniques as inputs to operational resource management models

The author has identified the following significant results. Successful operational applications of LANDSAT data were found for level 1 land use mapping, drainage network delineation, and aspen mapping. Visual LANDSAT interpretation using 1:125,000 color composite imagery was the least expensive method of obtaining timely level 1 land use data. With an average agricultural/rangeland interpretation accuracy in excess of 80%, such a data source was considered the most cost effective of those sources available to state agencies. Costs do not compare favorably with those incurred using the present method of extracting land use data from historical tabular summaries. The cost increase in advancing from the present procedure to a satellite-based data source was justified in terms of expanded data content

Towards Understanding the Politics of Flex Crops and Commodities: Implications for Research and Policy Advocacy

This discussion paper offers a preliminary exploration of the concept and phenomenon of “flex crops and commodities”, building on an earlier and initial analysis and abbreviated idea put forward by some of the authors of this paper. We discuss the dual concepts of the “multiple-ness” and “flexible-ness” of crops and commodities as two distinct but intertwined dimensions of some key crops and commodities. These key crops and commodities are shaped by the changing global context that is itself (re)moulded in large part by the convergence of multiple crises and the various responses to those crises. Building on these dual concepts, we will identify and explain the minimum requirements for crop and commodity flexing. We will also try to typologize the various types of crop and commodity flexing, namely, “real flexing”, “anticipated/speculated flexing”, and “imagined flexing”—to allow for a deeper examination of these interrelated processes. The boundaries between these categories (multiple/flexible, real, anticipated and imagined) are not always clearly demarcated, requiring us to examine the issue of flex crops and commodities in a more interlinked manner. We will focus our initial exploration on the political dynamics of such interactions and intersections, looking into the factors that encourage or discourage, facilitate or hinder maximization of the “multiple-ness” and/or “flexible-ness” of particular crops and commodities. Finally, and as a way of closing, we will outline the implications of these dynamics for how we think of engaged research, public actions and policy advocacy, including a brief discussion of what we call “flex policy narratives” by governments and corporations.

Who Are America's Poor Children? Examining Health Disparities Among Children in the United States

Good health goes a long way, as research suggests that poor health in childhood not only impedes early child development, but can also have lasting consequences on children's future health and wellbeing. Although many would agree that a health is a fundamental right, children born into low-income families are less likely to enjoy this right. As part of NCCP's Who are America's Poor Children? series, this report draws on the National Health Interview Survey (NHIS) and the National Health and Nutrition Examination Survey (NHANES) to provide an overview of the health of America's children by poverty status from 2007 to 2009. To assess health disparities between poor and nonpoor children, it identifies a list of publicly available annual indicators within the following five broad domains of health: environmental health, health insurance coverage, access to healthcare services, behavior, and health outcomes. We find evidence of disparities between poor and nonpoor children within each of these five domains. These findings are consistent with two longstanding conclusions within the field of public health. First, "the relationship between socioeconomic status and health is one of the most robust and well documented findings in social science." Second, this relationship is reciprocal, as poverty detracts from resources used to maintain health, while poor health detracts from the educational and employment paths to income mobility. Following a framework developed by the Federal Interagency Forum on Child and Family Statistics, this paper suggests five key domains of health: environmental health, health insurance coverage, access to healthcare services, behavior, and health outcomes. While income is one of the leading predictors of health disparities, it is not the only one (and often is associated with other risks). The influences of race and ethnicity, neighborhood safety and collective efficacy, family structure, and many other factors, are also critically important, though not examined here. With the exception of the two readily available survey indicators of reported emotional difficulties and attention deficit and hyperactivity disorder, we do not examine indicators of social-emotional well-being and mental health

Compartmentalized Connexin 43 S-Nitrosylation/Denitrosylation Regulates Heterocellular Communication in the Vessel Wall

Objective-To determine whether S-nitrosylation of connexins (Cxs) modulates gap junction communication between endothelium and smooth muscle. Methods and Results-Heterocellular communication is essential for endothelium control of smooth muscle constriction; however, the exact mechanism governing this action remains unknown. Cxs and NO have been implicated in regulating heterocellular communication in the vessel wall. The myoendothelial junction serves as a conduit to facilitate gap junction communication between endothelial cells and vascular smooth muscle cells within the resistance vasculature. By using isolated vessels and a vascular cell coculture, we found that Cx43 is constitutively S-nitrosylated on cysteine 271 because of active endothelial NO synthase compartmentalized at the myoendothelial junction. Conversely, we found that stimulation of smooth muscle cells with the constrictor phenylephrine caused Cx43 to become denitrosylated because of compartmentalized S-nitrosoglutathione reductase, which attenuated channel permeability. We measured S-nitrosoglutathione breakdown and NOx concentrations at the myoendothelial junction and found S-nitrosoglutathione reductase activity to precede NO release. Conclusion-This study provides evidence for compartmentalized S-nitrosylation/denitrosylation in the regulation of smooth muscle cell to endothelial cell communication. (Arterioscler Thromb Vasc Biol. 2011;31:399-407.

Calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis: a rapid method to evaluate inhibitors of arachidonic acid metabolism in vivo

The present investigation characterizes calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis in the rat. Intraperitoneal injection of A-23187 (20 μg/rat) stimulated marked biosynthesis of 6-keto-PGF1α (6-KPA), TxB2, LTC4 and LTB4, with no detectable changes on levels of PGE2. Levels of all eicosanoids decreased rapidly after a peak which was seen as early as 5 min. Enzyme markers of cellular contents of neutrophils and mononuclear cells, MPO and NAG respectively, decreased rapidly after ionophore injection; this was followed by increases after 60 min. Indomethacin, a selective cyclooxygenase inhibitor, and zileuton and ICI D-2138, two selective 5-lipoxygenase inhibitors attenuated prostaglandin and leukotriene pathways respectively. Oral administration of zileuton (20 mg/kg, p.o.) inhibited LTB4 biosynthesis for up to 6 h suggesting a long duration of pharmacological activity in the rats consistent with its longer half-life. The rapid onset and the magnitude of increases in levels of eicosanoids render the ionophore induced peritoneal eicosanoid biosynthesis a useful model to evaluate pharmacological profiles of inhibitors of eicosanoid pathways in vivo

Pediatric Medical Homes: Laying the Foundation of a Promising Model of Care

In recent years the nation's health care system has accelerated the development and implementation of a new model of patient care -- the medical home. States, insurers, health care delivery systems, and individual practices are increasingly exploring ways to leverage medical homes to improve the quality of care and limit increases in health care costs. This Thrive report describes the current status of the medical home concept and explains how it has been broadly defined, applied to children, and measured. It also reports on the number and characteristics of American children served by medical homes and discusses opportunities to further leverage medical homes to improve medical care and achieve better health outcomes for young children, with a particular focus on the coordination of care for vulnerable children. The medical home concept builds on the foundations of primary care and managed care. Though the model is increasingly being recommended for all people, medical home implementation often prioritizes the goal of improving the quality and management of care for individuals with chronic disease or other critical health-impacting factors. Originally conceived by pediatricians over four decades ago, the medical home concept has become much more visible recently, particularly within the context of health care reform. The development of the medical home model of primary care can be traced back to the 1960s, but not until the 1990s did the advent of managed care prompt more focused exploration of potential payment models that could support broader implementation of medical homes. As a result, recent years have seen a high degree of activity around the definition, accreditation, and reimbursement of medical homes

Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1.

Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in Neurofibromin 1 (NF1). NF1 patients present with a variety of clinical manifestations and are predisposed to cancer development. Many NF1 animal models have been developed, yet none display the spectrum of disease seen in patients and the translational impact of these models has been limited. We describe a minipig model that exhibits clinical hallmarks of NF1, including café au lait macules, neurofibromas, and optic pathway glioma. Spontaneous loss of heterozygosity is observed in this model, a phenomenon also described in NF1 patients. Oral administration of a mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor suppresses Ras signaling. To our knowledge, this model provides an unprecedented opportunity to study the complex biology and natural history of NF1 and could prove indispensable for development of imaging methods, biomarkers, and evaluation of safety and efficacy of NF1-targeted therapies