Crafting Audience Encounters

This paper documents a research project demonstrating the potential to engage audiences, promote practitioners and add value to craft work, through the use of relatively low-cost and accessible digital communications technologies in the context of a public exhibition. The project involves: filming, photographing and editing together audio-visual material; the creation of a website from which to access films and leave feedback; and a number of options for viewing web-based film footage including Quick Response (QR) codes and smartphone technology, iPads and a desktop computer to deliver internet-hosted content. ‘In the Frame’ is an interdisciplinary research project involving a team of researchers, film-makers and technologists, and Level 3 Contemporary Craft students at Falmouth University. It is a pilot study within Supercrafted, * a two year research project at Falmouth University, exploring and developing online digital interaction of benefit to craft practitioners and stakeholders in the craft value chain, including audiences, customers, makers and suppliers

Impact of Groundwater Flow on Permafrost Degradation and Transportation Infrastructure Stability

INE/AUTC 13.0

High-efficiency light-wave control with all-dielectric optical Huygens' metasurfaces

Optical metasurfaces have developed as a breakthrough concept for advanced wave-front engineering enabled by subwavelength resonant nanostructures. However, reflection and/or absorption losses as well as low polarisation-conversion efficiencies pose a fundamental obstacle for achieving high transmission efficiencies that are required for practical applications. Here we demonstrate, for the first time to our knowledge, highly efficient all-dielectric metasurfaces for near-infrared frequencies using arrays of silicon nanodisks as meta-atoms. We employ the main features of Huygens' sources, namely spectrally overlapping electric and magnetic dipole resonances of equal strength, to demonstrate Huygens' metasurfaces with a full transmission-phase coverage of 360 degrees and near-unity transmission, and we confirm experimentally full phase coverage combined with high efficiency in transmission. Based on these key properties, we show that all-dielectric Huygens' metasurfaces could become a new paradigm for flat optical devices, including beam-steering, beam-shaping, and focusing, as well as holography and dispersion control.Comment: 17 pages, 5 figure

Portraying the hosts: Stellar science from planet searches

Information on the full session can be found on this website: https://sites.google.com/site/portrayingthehostscs18/We present a compendium of the splinter session on stellar science from planet searches that was organized as part of the Cool Stars 18 conference. Seven speakers discussed techniques to infer stellar information from radial velocity, transit and microlensing data, as well as new instrumentation and missions designed for planet searches that will provide useful for the study of the cool stars

Evolutionary consequences of intra-patient phage predation on microbial populations

The impact of phage predation on bacterial pathogens in the context of human disease is not currently appreciated. Here, we show that predatory interactions of a phage with an important environmentally transmitted pathogen, Vibrio cholerae, can modulate the evolutionary trajectory of this pathogen during the natural course of infection within individual patients. We analyzed geographically and temporally disparate cholera patient stool samples from Haiti and Bangladesh and found that phage predation can drive the genomic diversity of intra-patient V. cholerae populations. Intra-patient phage-sensitive and phage-resistant isolates were isogenic except for mutations conferring phage resistance, and moreover, phage-resistant V. cholerae populations were composed of a heterogeneous mix of many unique mutants. We also observed that phage predation can significantly alter the virulence potential of V. cholerae shed from cholera patients. We provide the first molecular evidence for predatory phage shaping microbial community structure during the natural course of infection in humans. DOI: http://dx.doi.org/10.7554/eLife.03497.00

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.

Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens, enabling transactivation and causing the receptor to become aggregation-prone. Here we show that these molecular chaperones recognize a region of the AR N-terminal domain (NTD), including a FQNLF motif, that interacts with the AR ligand-binding domain (LBD) upon activation. This suggests that competition between molecular chaperones and the LBD for the FQNLF motif regulates AR activation. We also show that, while the free NTD oligomerizes, binding to Hsp70 increases its solubility. Stabilizing the NTD-Hsp70 interaction with small molecules reduces AR aggregation and promotes its degradation in cellular and mouse models of the neuromuscular disorder spinal bulbar muscular atrophy. These results help resolve the mechanisms by which molecular chaperones regulate the balance between AR aggregation, activation and quality control