Dicyanidobis(thio­urea-κS)cadmium(II) monohydrate

In the title compound, [Cd(CN)2(CH4N2S)2]·H2O, the Cd atom lies on a twofold rotation axis and is bonded to two S atoms of thio­urea and two C atoms of the cyanide anions in a distorted tetra­hedral environment. The crystal structure is stabilized by N—H⋯N(CN), N—H⋯O, O—H⋯N and N—H⋯S hydrogen bonds

Differences in the prevalence of diagnosis of overweight-obesity in Spanish children according to the diagnostic criteria set used

Objective: To examine relevant differences in the prevalence of overweight and obesity in children aged 2-15 years according to different sets of criteria (Orbegozo Foundation, International Obesity Task Force and World Health Organization), and how their use affects the trends in obesity recorded for both sexes between 1995 and 2011 in Spain. Method: Cross-sectional study, a population between 2 and 15 years. Three diagnosis criteria of overweight and obesity were be used. Results: The boys according to the three criteria, showed higher values of overweight and obesity compared to the girls. The lowest levels of overweight and obesity were observed using the Orbegozo tables. Discussion: The prevalence of overweight and obesity varies significantly according to the criteria used to define overweight and obesity. The percentiles of the Foundation Orbegozo gave the lowest estimates and the standards of growth of the World Health Organization were higher

Poly[[μ3-chlorido-bis(μ2-thio­urea-κS)disilver(I)] nitrate]

The mol­ecular structure of the title polymeric complex, {[Ag2Cl(CH4N2S)2]NO3}n, consists of a binuclear cationic complex and a nitrate counter-ion. The cationic complex contains two bridging thio­urea (Tu) ligands and a triply bridging μ3-Cl anion. The latter is probably released from 2-amino­ethane­thiol hydro­chloride during the synthesis. The coordination environment around the two AgI atoms is different; one is trigonal planar, being coordinated by two thio­urea ligands through the S atoms and to one Cl− ion, while in the other the AgI atom is tetra­hedrally coordinated by two thio­urea ligands through the S atoms and to two Cl− ions. These units aggregate through the Cl− anion and the Tu S atoms, forming a chain propagating in [100]. In the crystal structure, the polymeric chains are linked via N—H⋯O and N—H⋯Cl hydrogen bonds, forming a double layer two-dimensional network propagating in (011)

Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound

Objective(s): Newer organo-metallic, specifically gold (III) complexes with multiple ligands are currently being formulated with primary focus of having increased anti-cancerous properties and decreased cytotoxicity. In this study, histological toxicity profile of a newly formulated anti-cancerous gold (III) compound [trans-(±)-1,2-(DACH)2Au]Cl3 Bis(trans-1,2-Diaminocyclohexane) was investigated by evaluation of kidney and liver tissues of treated rats.Materials and Methods: This is a quasi-experimental study. In acute toxicity component of the study, (n = 16) male rats weighing between 200–250 g were administered single, variable concentration of the gold (III) compound, [trans-(±)-1,2-(DACH)2Au]Cl3 Bis(trans-1,2-Diaminocyclohexane) to determine LD50 (dose that is lethal to 50% of rats). An IP injection of 2.3 mg/kg (equivalent to 1/10 of LD50) was injected for 14 consecutive days to (n=10) male rats in the sub-acute component of the study. Autopsy preservation of liver and kidney tissue in buffered formalin, sample processing, histopathological evaluation, and comparison with unremarkable controls (n=5) was conducted sequentially. Results: A dose of 2.3 mg/kg did not produce any tubular necrosis in kidney specimens. Mild interstitial inflammation with prominence of plasma cells was the main histological alteration. Plasmacytic pyelitis was also seen. Varying extents of cytoplasmic vacuolization and mild focal lobular and portal inflammation were predominant hepatic microscopic findings. Conclusion: [trans-(±)-1,2-(DACH)2Au]Cl3 Bis(trans-1,2-Diaminocyclohexane) produced no histological damage in renal and hepatic tissues of rats. This very limited sample animal-based study points to the relative safety of this new gold compound. However, there is a need to compare this compound with established drugs in a comparative non-animal based study

Synthesis, CP-MAS NMR Characterization, and Antibacterial Activities of Glycine and Histidine Complexes of Cd(SeCN) 2

The synthesis and characterization of cadmium and mercury complexes of selenocyanate of the type [(L)M(SeCN)2] are described, where L is L-Histidine (His) or L-Glycine (Gly) and M is Cd2+ or Hg2+. These complexes are obtained by the reaction of 1 equivalent of respective amino acids with metal diselenocyanate precursor in a mixture of solvents (methanol : water = 1 : 1). These synthesized compounds are characterized by analytical and various spectroscopic techniques such as elemental analysis (EA), IR, H,1 and C13 NMR in solution and in the solid state for C13 and N15. The in vitro antibacterial activities of these complexes have been investigated with standard type cultures of Escherichia coli (MTCC 443), Klebsiella pneumoniae (MTCC 109), Pseudomonas aeruginosa (MTCC 1688), Salmonella typhi (MTCC 733), and Staphylococcus aureus (MTCC 737)