Loving You No Matter What You Do : Ai\u27s Dramatic Monologues, 1970s Asian American Feminisms, and Reproductive Justice

This essay makes visible the 1970s involvement of Asian American and Women of Color feminists in reproductive justice. Grounded in the Asian American feminist praxis of remembering, this essay analyzes how three dramatic monologues by the Asian American mixed-race poet Ai engage with the discourses of reproduce justice set forth by Asian American and Women of Color activists leading up to the 1973 Roe v. Wade decision. Using an Asian American feminist lens, this paper argues that the speakers in Ai’s monologues utilize these discourses circulating about abortion and women’s health care to construct images of the treatment of dispossessed women that make emphatic the importance of access to safe, affordable, and legal reproductive care due to the medical and cultural apparatuses that imperil women’s lives. Close readings of Ai\u27s monologues illuminate the ways in which her work representationally recognizes her understanding of difference as a mixed-race poet and exposes intra-racial differences regarding reproductive care within Asian American communities

Efficient markets: land and slave prices in Henrico County, Virginia, 1782-1863

Asset market efficiency fosters rational decisions on allocating resources, both individually and socially, and thus helps determine individuals' wealth accumulation and nations' economic growth. To date, however, there are little systematic data available for, and even less analysis of, US capital markets during the late eighteenth and mid-nineteenth centuries, a period of great transformation and growth. This paper is a preliminary exploration of market efficiency in two early US asset markets, looking at prices of land and slaves in Henrico County, Virginia, from the 1780s to the 1860s. Our hypothesis tests on both the price of and returns to Henrico County land and slaves provide evidence that land and slave markets in late eighteenth and early nineteenth century US were weak-form efficient, suggesting that available information was quickly and fully incorporated into prices in these early North American asset markets.efficient markets, random walk, Dickey-Fuller, KPSS test, slave prices, land prices

A Two Hour Quasi-Period in an Ultra-luminous X-Ray source in NGC628

Quasi-periodic oscillations and X-ray spectroscopy are powerful probes of black hole masses and accretion disks, and here we apply these diagnostics to an ultraluminous X-ray source (ULX) in the spiral galaxy NGC628 (M74). This object was observed four times over two years with the Chandra X-ray Observatory and XMM-Newton, with three long observations showing dramatic variability, distinguished by a series of outbursts with a quasi-period (QPO) of 4,000-7,000 seconds. This is unique behavior among both ULXs and Galactic X-ray binaries due to the combination of its burst-like peaks and deep troughs, its long quasi-periods, its high variation amplitudes of $>90$%, and its substantial variability between observations. The X-ray spectra is fitted by an absorbed accretion disk plus a power-law component, suggesting the ULX was in a spectral state analogous to the Low Hard state or the Very High state of Galactic black hole X-ray binaries. A black hole mass of $\sim2$--$20\times10^3 M_\odot$ is estimated from the $f_b$--$M_\bullet$ scaling relation found in the Galactic X-ray binaries and active galactic nuclei.Comment: 12 pages, 3 figures. accepted for publication in ApJ Lette

Childhood maltreatment, psychological resources, and depressive symptoms in women with breast cancer.

Childhood maltreatment is associated with elevated risk for depression across the human lifespan. Identifying the pathways through which childhood maltreatment relates to depressive symptoms may elucidate intervention targets that have the potential to reduce the lifelong negative health sequelae of maltreatment exposure. In this cross-sectional study, 271 women with early-stage breast cancer were assessed after their diagnosis but before the start of adjuvant treatment (chemotherapy, radiation, endocrine therapy). Participants completed measures of childhood maltreatment exposure, psychological resources (optimism, mastery, self-esteem, mindfulness), and depressive symptoms. Using multiple mediation analyses, we examined which psychological resources uniquely mediated the relationship between childhood maltreatment and depressive symptoms. Exposure to maltreatment during childhood was robustly associated with lower psychological resources and elevated depressive symptoms. Further, lower optimism and mindfulness mediated the association between childhood maltreatment and elevated depressive symptoms. These results support existing theory that childhood maltreatment is associated with lower psychological resources, which partially explains elevated depressive symptoms in a sample of women facing breast cancer diagnosis and treatment. These findings warrant replication in populations facing other major life events and highlight the need for additional studies examining childhood maltreatment as a moderator of treatment outcomes

Nectar Yeasts in the Tall Larkspur Delphinium barbeyi (Ranunculaceae) and Effects on Components of Pollinator Foraging Behavior

Microorganisms frequently colonize the nectar of angiosperm species. Though capable of altering a suite of traits important for pollinator attraction, few studies exist that test the degree to which they mediate pollinator foraging behavior. The objective of our study was to fill this gap by assessing the abundance and diversity of yeasts associated with the perennial larkspur Delphinium barbeyi (Ranunculaceae) and testing whether their presence affected components of pollinator foraging behavior. Yeasts frequently colonized D. barbeyi nectar, populating 54–77% of flowers examined depending on site. Though common, the yeast community was species-poor, represented by a single species, Metschnikowia reukaufii. Female-phase flowers of D. barbeyi were more likely to have higher densities of yeasts in comparison to male-phase flowers. Pollinators were likely vectors of yeasts, as virgin (unvisited) flowers rarely contained yeasts compared to flowers open to pollinator visitation, which were frequently colonized. Finally, pollinators responded positively to the presence of yeasts. Bombus foragers both visited and probed more flowers inoculated with yeasts in comparison to uninoculated controls. Taken together, our results suggest that variation in the occurrence and density of nectar-inhabiting yeasts have the potential to alter components of pollinator foraging behavior linked to pollen transfer and plant fitness

`I make up a silly name': Understanding Children's Perception of Privacy Risks Online

Children under 11 are often regarded as too young to comprehend the implications of online privacy. Perhaps as a result, little research has focused on younger kids' risk recognition and coping. Such knowledge is, however, critical for designing efficient safeguarding mechanisms for this age group. Through 12 focus group studies with 29 children aged 6-10 from UK schools, we examined how children described privacy risks related to their use of tablet computers and what information was used by them to identify threats. We found that children could identify and articulate certain privacy risks well, such as information oversharing or revealing real identities online; however, they had less awareness with respect to other risks, such as online tracking or game promotions. Our findings offer promising directions for supporting children's awareness of cyber risks and the ability to protect themselves online.Comment: 13 pages, 1 figur

Periodic Radio Emission From the M7 Dwarf 2mass J13142039+1320011: Implications for the Magnetic Field Topology

We present multi-epoch radio and optical observations of the M7 dwarf 2MASS J13142039+1320011. We detect a ∼ 1 mJy source at 1.43, 4.86, 8.46 and 22.5 GHz, making it the most luminous radio emission over the widest frequency range detected from an ultracool dwarf to date. A 10 hr VLA observation reveals that the radio emission varies sinusoidally with a period of 3.89±0.05 hr, and an amplitude of ≈ 30% at 4.86 GHz and ≈ 20% at 8.46 GHz. The periodicity is also seen in circular polarization, where at 4.86 GHz the polarization reverses helicity from left- to right-handed in phase with the total intensity. An archival detection in the FIRST survey indicates that the radio emission has been stable for at least a decade. We also detect periodic photometric variability in several optical filters with a period of 3.79 hr, and measure a rotation velocity of vsini = 45 ± 5 km s−1, in good agreement with the radio and optical periods. The period and rotation velocity allow us to place a lower limit on the radius of the source of & 0.12 R⊙, about 30% larger than theoretical expectations. The properties of the radio emission can be explained with a simple model of a magnetic dipole mis-aligned relative to the stellar rotation axis, with the sinusoidal variations and helicity reversal due to the rotation of the magnetic poles relative to our line of sight. The long-term stability of the radio emission indicates that the magnetic field (and hence the dynamo) is stable on a much longer timescale than the convective turn-over time of ∼ 0.2 yr. If the radio emission is due to the electron cyclotron maser process, the inferred magnetic field strength reaches at least 8 kG.Astronom

The UHRF1 protein is a key regulator of retrotransposable elements and innate immune response to viral RNA in human cells

While epigenetic mechanisms such as DNA methylation and histone modification are known to be important for gene suppression, relatively little is still understood about the interplay between these systems. The UHRF1 protein can interact with both DNA methylation and repressive chromatin marks, but its primary function in humans has been unclear. To determine what that was, we first established stable UHRF1 knockdowns (KD) in normal, immortalized human fibroblasts using targeting shRNA, since CRISPR knockouts (KO) were lethal. Although these showed a loss of DNA methylation across the whole genome, transcriptional changes were dominated by the activation of genes involved in innate immune signalling, consistent with the presence of viral RNA from retrotransposable elements (REs). We confirmed using mechanistic approaches that 1) REs were demethylated and transcriptionally activated; 2) this was accompanied by activation of interferons and interferon-stimulated genes and 3) the pathway was conserved across other adult cell types. Restoring UHRF1 in either transient or stable KD systems could abrogate RE reactivation and the interferon response. Notably, UHRF1 itself could also re-impose RE suppression independent of DNA methylation, but not if the protein contained point mutations affecting histone 3 with trimethylated lysine 9 (H3K9me3) binding. Our results therefore show for the first time that UHRF1 can act as a key regulator of retrotransposon silencing independent of DNA methylation

Assessment of an incentivised scheme to provide annual health checks in primary care for adults with intellectual disability: a longitudinal cohort study

Background People with intellectual disabilities (ID) have many comorbidities but experience inequities in access to health care. National Health Service England uses an opt-in incentive scheme to encourage annual health checks of patients with ID in primary care. We investigated whether the first 3 years of the programme had improved health care of people with ID. Methods We did a longitudinal cohort study that used data from The Health Improvement Network primary care database. We did multivariate logistic regression to assess associations between various characteristics and whether or not practices had opted in to the incentivised scheme. Findings We assessed data for 8692 patients from 222 incentivised practices and those for 918 patients in 48 non-incentivised practices. More blood tests (eg, total cholesterol, odds ratio [OR] 1·88, 95% CI 1·47–2·41, p<0·0001) general health measurements (eg, smoking status, 6·0, 4·10–8·79, p<0·0001), specific health assessments (eg, hearing, 24·0, 11·5–49·9, p<0·0001), and medication reviews (2·23, 1·68–2·97, p<0·0001) were done in incentivised than in non-incentivised practices, and more health action plans (6·15, 1·41–26·9, p=0·0156) and secondary care referrals (1·47, 1·05–2·05, p=0·0256) were made. Identification rates were higher in incentivised practices for thyroid disorder (OR 2·72, 95% CI 1·09–6·81, p=0·0323), gastrointestinal disorders (1·94, 1·03–3·65, p=0·0390), and obesity (2·49, 1·76–3·53, p<0·0001). Interpretation Targeted annual health checks for people with ID in primary care could reduce health inequities