Strategic investment in tuberculosis control in the Republic of Bulgaria

As Bulgaria transitions away from Global Fund grant, robust estimates of the comparative impact of the various response strategies under consideration are needed to ensure sustained effectiveness of the tuberculosis (TB) programme. We tailored an established mathematical model for TB control to the epidemic in Bulgaria to project the likely outcomes of seven intervention scenarios. Under existing programmatic conditions projected forward, the country's targets for achieving TB elimination in the coming decades will not be achieved. No interventions under consideration were predicted to accelerate the baseline projected reduction in epidemiological indicators significantly. Discontinuation of the 'Open Doors' program and activities of non-governmental organisations would result in a marked exacerbation of the epidemic (increasing incidence in 2035 by 6-8% relative to baseline conditions projected forward). Changing to a short course regimen for multidrug-resistant TB (MDR-TB) would substantially decrease MDR-TB mortality (by 21.6% in 2035 relative to baseline conditions projected forward). Changing to ambulatory care for eligible patients would not affect TB burden but would be markedly cost-saving. In conclusion, Bulgaria faces important challenges in transitioning to a primarily domestically-financed TB programme. The country should consider maintaining currently effective programs and shifting towards ambulatory care to ensure program sustainability

Optimization of Energy Extraction Using Definite Geometry Prisms in Airflow

An approximate method for analysis and synthesis of moving rigid bodies (prisms) in the airflow without using numerical methods of space-time programming techniques is described by applying a fluid (air)–rigid solid body interaction concept for engineering applications through a straightforward mathematical model. The interaction of rigid body (prism) and air is encountered in different cases: moving body (prism) in the air; stationary bodies (prism) in the airflow; moving body (prism) in the airflow. The complicated task of rigid body (prism) and air interaction is simplified by using superposition principles, i.e., by taking into account the upstream and downstream rigid body (prism) and air interaction phenomenon, which has been found to be different under varying speeds. Numerical results obtained for various forms of prisms are shown for constant air–speed, where the steady state Reynolds-averaged Navier–Stokes (RANS) equation is solved by using k-ε realizable turbulence model. A detailed explanation to support the proposed approximate method is given by using numerical results obtained in ANSYS computations. All equations are formed based on laws of classical mechanics; the interaction of viscous forces is neglected in forming the mathematical model. Numerical results for different model prisms are compared and the theoretical results discussed in detail. The mathematical model in the present paper is applicable only to bodies that undergo a rectilinear translation motion. In the final part of the present paper, the proposed method is used in the synthesis and optimization task of energy extraction by considering the motion of a variable parameter prism in the airflow

Silk Microfiber Reinforced Calcium Phosphate Bone Cements for Local Drug Delivery

To improve the mechanical properties of α-tricalcium phosphate (α-TCP) based CPC for drug delivery applications, cements were reinforced with silk microfibers. The effect of drug loaded microcapsules and reinforcing fibres on CPC mechanical properties and drug release kinetics was investigated

Integration of heritage buildings and sites in their surroundings

This public report provides an overview of the problems raised by the management of heritage buildings and sites (HBs/sites) in their surroundings. A multidisciplinary team comprising conservation professionals, art historians, archaeologists, architects, biologists, civil engineers and information technology experts have joined forces within the framework of the European Cooperation in Science and Technology Action TD1406 - i2MHB (Innovation in Intelligent Management of Heritage Buildings) to provide their expertise and experience on the risks to which HBs/sites are exposed (urban development, infrastructure works, demographical changes, natural and technological hazards, bio-deterioration, lack of cultural heritage education and technical knowledge and skills, etc.). Traditional and new approaches to manage the principal risks are then developed. Nine representative European HBs/sites are used to illustrate the different problems raised and to offer possible solutions. The report ends with a number of recommendations to better integrate HBs/sites in their surroundings. This report is addressed to policy makers at the local, regional and national governments; economical and industrial players; research and education stakeholders; and, the public to the preservation and valorisation of HBs/sites in their surroundings. We hope that readers will find tentative answers to their question(s) on the difficulties encountered by the management of HBs/sites in their surroundings. Further reading is available through the references and the online literature provided