Considerations on reduction of indoor air pollution from radioactive emissions from building materials and the ground

The goal of this paper is to study the reduction of health risks from indoor radioactive pollutants, as thoron emissions from common building materials, and radon emission from both building materials and the ground. In particular, when dealing with the indoor environment, one of the most important hazard is represented by radon gas, considered by the World Health Organization (WHO) as the second largest cause of lung cancer, cigarette smoke being the first. Such a radioactive gas belongs to the natural radioactive background of radiation, and its presence all over the world is unavoidable. Radon gas density varies due to microclimatic factors such as temperature, air pressure, humidity and changes in ground layers. Radon gas emerges from the ground and penetrates building basements, accumulating itself into the indoor air, and being breathed in by people. Taking care of the airtightness of windows allows the radon concentration to build up, in some cases beyond reference levels, together with other chemical pollutants, i.e. combustion residues and solvents. The EU Basic Safety Standards, stated in the Council Directive 2013/59/Euratom, based on the last recommendations from the International Commission on Radiological Protection (ICRP) and from WHO, are focusing on risks related to radon gas concentration inside dwellings and working places. On considering that Council Directive 2013/59 Euratom has to be transposed into law by each EU Member State by February 2018, it is recommended that radon issues have to be considered during the design phase of the building construction. For NZEB applications a special attention is requested when energy consumption is reduced lower and lower by taking care of airtightness. In such a case, indoor pollutants (chemical, radioactive, particulate, etc.) can significantly accumulate beyond safe levels. This paper describes measurements and remedial actions of study cases, focusing on public and domestic environments

Evaluation of Resistance to TSWV and Agronomic Behaviour of Some TSWV-Resistant Tomato Genotypes in Southern Italy

A two-year research was carried out in Ofanto valley (Basilicata region, southern Italy) in 2006-2007, for evaluating agronomic behaviour of new processing tomato genotypes resistant to tomato spotted wilt virus (TSWV) and ascertaining their effective resistance to the virus. Five TSWV-resistant genotypes (cultivars and lines) were compared in each year the TSWV susceptible cultivar ‘Perfectpeel’ was used as a control. Two transplant dates were adopted in both years: 1) mean-early and 2) mean-late. A split-plot design with 3 reps was followed in the two years. Yield and fruit quality were considered as agronomic traits. About virological aspects, field observations and laboratory analysis (ELISA, IME) were carried out during crop cycles. Phytoplasma infection frequency was also assessed for the same plants. The control cultivar ‘Perfectpeel’ resulted highly productive in both years that were however characterized by low incidence of virus infections; beside, among new genotypes ‘Vespro’ and ‘Suerte’ gave a good yield, while ‘Candia’ and ‘Isi 23259’ exhibited high fruit quality. Virological studies showed that the new processing tomato genotypes were indeed TSWV-resistant. Finally, phytoplasma infections had a dissimilar incidence among plants of the tested genotypes

Geographic and socioeconomic variation of sodium and potassium intake in Italy : results from the MINISAL-GIRCSI programme

Objectives To assess geographic and socioeconomic gradients in sodium and potassium intake in Italy. Setting Cross-sectional survey in Italy. Participants 3857 men and women, aged 39–79 years, randomly sampled in 20 regions (as part of a National cardiovascular survey of 8714 men and women). Primary outcome measures Participants’ dietary sodium and potassium intakes were measured by 24 h urinary sodium and potassium excretions. 2 indicators measured socioeconomic status: education and occupation. Bayesian geoadditive models were used to assess spatial and socioeconomic patterns of sodium and potassium intakes accounting for sociodemographic, anthropometric and behavioural confounders. Results There was a significant north-south pattern of sodium excretion in Italy. Participants living in southern Italy (eg, Calabria, Basilicata and Puglia >180 mmol/24 h) had a significantly higher sodium excretion than elsewhere (eg, Val d'Aosta and Trentino-Alto Adige <140 mmol/24 h; p<0.001). There was a linear association between occupation and sodium excretion (p<0.001). When compared with occupation I (top managerial), occupations III and IV had a 6.5% higher sodium excretion (coefficients: 0.054 (90% credible levels 0.014, 0.093) and 0.064 (0.024, 0.104), respectively). A similar relationship was found between educational attainment and sodium excretion (p<0.0001). When compared with those with a university degree, participants with primary and junior school education had a 5.9% higher urinary sodium (coefficients: 0.074 (0.031, 0.116) and 0.038 (0.001, 0.075), respectively). The socioeconomic gradient explained the spatial variation. Potassium excretion was higher in central regions and in some southern regions. Those in occupation V (low-skill workers) showed a 3% lower potassium excretion compared with those in occupation I. However, the socioeconomic gradient only partially explained the spatial variation. Conclusions Salt intake in Italy is significantly higher in less advantaged social groups. This gradient is independent of confounders and explains the geographical variation

Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells

Background: Cellular plasticity confers cancer cells the ability to adapt to microenvironmental changes, a fundamental requirement for tumour progression and metastasis. The epithelial to mesenchymal transition (EMT) is a transcriptional programme associated with increased cell motility and stemness. Besides EMT, the mesenchymal to amoeboid transition (MAT) has been described during tumour progression but to date, little is known about its transcriptional control and involvement in stemness. The aim of this manuscript is to investigate (i) the transcriptional profile associated with the MAT programme and (ii) to study whether MAT acquisition in melanoma cancer cells correlates with clonogenic potential to promote tumour growth. Results: By using a multidisciplinary approach, we identified four different treatments able to induce MAT in melanoma cells: EphA2 overexpression, Rac1 functional inhibition using its RacN17 dominant negative mutant, stimulation with Ilomastat or treatment with the RhoA activator Calpeptin. First, gene expression profiling identified the transcriptional pathways associated with MAT, independently of the stimulus that induces the MAT programme. Notably, gene sets associated with the repression of mesenchymal traits, decrease in the secretion of extracellular matrix components as well as increase of cellular stemness positively correlate with MAT. Second, the link between MAT and stemness has been investigated in vitro by analysing stemness markers and clonogenic potential of melanoma cells undergoing MAT. Finally, the link between MAT inducing treatments and tumour initiating capability has been validated in vivo. Conclusion: Taken together, our results demonstrate that MAT programme in melanoma is characterised by increased stemness and clonogenic features of cancer cells, thus sustaining tumour progression. Furthermore, these data suggest that stemness is not an exclusive feature of cells undergoing EMT, but more generally is associated with an increase in cellular plasticity of cancer cells

Burnout in cardiac anesthesiologists. results from a national survey in italy

Objective: There is increasing burnout incidence among medical disciplines, and physicians working in emergency settings seem at higher risk. Cardiac anesthesiology is a stressful anesthesiology subspecialty dealing with high-risk patients. The authors hypothesized a high risk of burnout in cardiac anesthesiologists. Design: National survey conducted on burnout Setting: Italian cardiac centers. Participants: Cardiac anesthesiologists. Interventions: The authors administered via email an anonymous questionnaire divided into 3 parts. The first 2 parts evaluated workload and private life. The third part consisted of the Maslach Burnout Inventory test with its 3 constituents: high emotional exhaustion, high depersonalization, and low personal accomplishment. Measurements and Main Results: The authors measured the prevalence and risk of burnout through the Maslach Burnout Inventory questionnaire and analyzed factors influencing burnout. Among 670 contacts from 71 centers, 382 cardiac anesthesiologists completed the survey (57%). The authors found the following mean Maslach Burnout Inventory values: 14.5 ± 9.7 (emotional exhaustion), 9.1 ± 7.1 (depersonalization), and 33.7 ± 8.9 (personal accomplishment). A rate of 34%, 54%, and 66% of respondents scored in “high” or “moderate-high” risk of burnout (emotional exhaustion, depersonalization, and personal accomplishment, respectively). The authors found that, if offered to change subspecialty, 76% of respondents would prefer to remain in cardiac anesthesiology. This preference and parenthood were the only 2 investigated factors with a protective effect against all components of burnout. Significantly lower burnout scores were found in more experienced anesthesiologists. Conclusion: A relatively high incidence of burnout was found in cardiac anesthesiologists, especially regarding high depersonalization and low personal accomplishment. Nonetheless, most of the respondents would choose to remain in cardiac anesthesiology