Considerations on reduction of indoor air pollution from radioactive emissions from building materials and the ground

The goal of this paper is to study the reduction of health risks from indoor radioactive pollutants, as thoron emissions from common building materials, and radon emission from both building materials and the ground. In particular, when dealing with the indoor environment, one of the most important hazard is represented by radon gas, considered by the World Health Organization (WHO) as the second largest cause of lung cancer, cigarette smoke being the first. Such a radioactive gas belongs to the natural radioactive background of radiation, and its presence all over the world is unavoidable. Radon gas density varies due to microclimatic factors such as temperature, air pressure, humidity and changes in ground layers. Radon gas emerges from the ground and penetrates building basements, accumulating itself into the indoor air, and being breathed in by people. Taking care of the airtightness of windows allows the radon concentration to build up, in some cases beyond reference levels, together with other chemical pollutants, i.e. combustion residues and solvents. The EU Basic Safety Standards, stated in the Council Directive 2013/59/Euratom, based on the last recommendations from the International Commission on Radiological Protection (ICRP) and from WHO, are focusing on risks related to radon gas concentration inside dwellings and working places. On considering that Council Directive 2013/59 Euratom has to be transposed into law by each EU Member State by February 2018, it is recommended that radon issues have to be considered during the design phase of the building construction. For NZEB applications a special attention is requested when energy consumption is reduced lower and lower by taking care of airtightness. In such a case, indoor pollutants (chemical, radioactive, particulate, etc.) can significantly accumulate beyond safe levels. This paper describes measurements and remedial actions of study cases, focusing on public and domestic environments

Evaluation of Resistance to TSWV and Agronomic Behaviour of Some TSWV-Resistant Tomato Genotypes in Southern Italy

A two-year research was carried out in Ofanto valley (Basilicata region, southern Italy) in 2006-2007, for evaluating agronomic behaviour of new processing tomato genotypes resistant to tomato spotted wilt virus (TSWV) and ascertaining their effective resistance to the virus. Five TSWV-resistant genotypes (cultivars and lines) were compared in each year the TSWV susceptible cultivar ‘Perfectpeel’ was used as a control. Two transplant dates were adopted in both years: 1) mean-early and 2) mean-late. A split-plot design with 3 reps was followed in the two years. Yield and fruit quality were considered as agronomic traits. About virological aspects, field observations and laboratory analysis (ELISA, IME) were carried out during crop cycles. Phytoplasma infection frequency was also assessed for the same plants. The control cultivar ‘Perfectpeel’ resulted highly productive in both years that were however characterized by low incidence of virus infections; beside, among new genotypes ‘Vespro’ and ‘Suerte’ gave a good yield, while ‘Candia’ and ‘Isi 23259’ exhibited high fruit quality. Virological studies showed that the new processing tomato genotypes were indeed TSWV-resistant. Finally, phytoplasma infections had a dissimilar incidence among plants of the tested genotypes

Burnout in cardiac anesthesiologists. results from a national survey in italy

Objective: There is increasing burnout incidence among medical disciplines, and physicians working in emergency settings seem at higher risk. Cardiac anesthesiology is a stressful anesthesiology subspecialty dealing with high-risk patients. The authors hypothesized a high risk of burnout in cardiac anesthesiologists. Design: National survey conducted on burnout Setting: Italian cardiac centers. Participants: Cardiac anesthesiologists. Interventions: The authors administered via email an anonymous questionnaire divided into 3 parts. The first 2 parts evaluated workload and private life. The third part consisted of the Maslach Burnout Inventory test with its 3 constituents: high emotional exhaustion, high depersonalization, and low personal accomplishment. Measurements and Main Results: The authors measured the prevalence and risk of burnout through the Maslach Burnout Inventory questionnaire and analyzed factors influencing burnout. Among 670 contacts from 71 centers, 382 cardiac anesthesiologists completed the survey (57%). The authors found the following mean Maslach Burnout Inventory values: 14.5 ± 9.7 (emotional exhaustion), 9.1 ± 7.1 (depersonalization), and 33.7 ± 8.9 (personal accomplishment). A rate of 34%, 54%, and 66% of respondents scored in “high” or “moderate-high” risk of burnout (emotional exhaustion, depersonalization, and personal accomplishment, respectively). The authors found that, if offered to change subspecialty, 76% of respondents would prefer to remain in cardiac anesthesiology. This preference and parenthood were the only 2 investigated factors with a protective effect against all components of burnout. Significantly lower burnout scores were found in more experienced anesthesiologists. Conclusion: A relatively high incidence of burnout was found in cardiac anesthesiologists, especially regarding high depersonalization and low personal accomplishment. Nonetheless, most of the respondents would choose to remain in cardiac anesthesiology

Interactions between Natural Health Products and Oral Anticoagulants: Spontaneous Reports in the Italian Surveillance System of Natural Health Products

Introduction. The safety of vitamin K antagonists (VKA) use can be compromised by many popular herbal supplements taken by individuals. The literature reports that 30% of warfarin-treated patients self-medicates with herbs. Possible interactions represent an health risk. We aimed to identify all herbs-oral anticoagulants interactions collected in the Italian database of suspected adverse reactions to “natural health” products. Methods. The Italian database of spontaneous reports of suspected adverse reactions to natural products was analyzed to address herb-VKAs interactions. Results. From 2002 to 2009, we identified 12 reports with 7 cases of INR reduction in patients treated with warfarin (n = 3) and acenocoumarol (n = 4), and 5 cases of INR increase (all warfarin associated). It was reported 8 different herbal products as possibly interacting. Discussion. Our study confirms the risk of interactions, highlighting the difficulty to characterize them and their mechanisms and, finally, prevent their onset. The reported data underline the urgent need of healthcare providers being aware of the possible interaction between natural products and VKA, also because of the critical clinical conditions affecting patients. This is the first step to have the best approach to understand possible INR alterations linked to herb-VKA interaction and to rightly educate patients in treatment with VKA

Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells

Drug resistance of cancer cells is recognized as the primary cause of failure of chemotherapeutic treatment in most human cancers. Growing evidences support the idea that deregulated cellular metabolism is linked to such resistance. Indeed, both components of the glycolytic and mitochondrial pathways are involved in altered metabolism linked to chemoresistance of several cancers. Here we investigated the drug-induced metabolic adaptations able to confer advantages to docetaxel resistant prostate cancer (PCa) cells. We found that docetaxel-resistant PC3 cells (PC3-DR) acquire a pro-invasive behavior undergoing epithelial-to-mesenchymal-transition (EMT) and a decrease of both intracellular ROS and cell growth. Metabolic analyses revealed that PC3-DR cells have a more efficient respiratory phenotype than sensitive cells, involving utilization of glucose, glutamine and lactate by the mitochondrial oxidative phosphorylation (OXPHOS). Consequently, targeting mitochondrial complex I by metformin administration, impairs proliferation and invasiveness of PC3-DR cells without effects on parental cells. Furthermore, stromal fibroblasts, which cause a "reverse Warburg" phenotype in PCa cells, reduce docetaxel toxicity in both sensitive and resistant PCa cells. However, re-expression of miR-205, a microRNA strongly down-regulated in EMT and associated to docetaxel resistance, is able to shift OXPHOS to a Warburg metabolism, thereby resulting in an elevated docetaxel toxicity in PCa cells. Taken together, these findings suggest that resistance to docetaxel induces a shift from Warburg to OXPHOS, mandatory for conferring a survival advantage to resistant cells, suggesting that impairing such metabolic reprogramming could be a successful therapeutic approach.Associazione Italiana Ricerca sul Cancro (AIRC), Istituto Toscano Tumori and Regione Toscan