A Regulatory Impact Analysis (RIA) approach based on evolutionary association patterns

The present paper focuses on ex post analysis to asses the impact of an adopted policy by measuring system performance. Since accurate impact assessment requires in-depth knowledge of the structure underlying the system, this contribution proposes a suitable use of multidimensional data analysis (MDA) to investigate the associations characterizing the indicators/attributes of the system. The general aim is to identify homogeneous subsets of objects that are described by subsets of attributes. This approach was planned to study students performance in Italian universities: the focus is on student careers. The example data set is a data mart selected from the University of Macerata data base and refers to the students at the Economics Faculty from 2001 to 2007

Dynamic Visualization of Changes in Association Patterns

The present proposal deals with high-dimensional binary data collected in different occasions in time or space. Studying the associations of data collected at different occasions, a primary aim is to detect changes in the association structure from one occasion to another. A suitable exploratory technique for the analysis of multiple associations in high-dimensional data is the multiple correspondence analysis (MCA; Greenacre, 2007). However, the comparison of MCA factorial displays referring to different occasions is meaningless. A possible solution to link the association structures of different data batches is to start from an MCA display of a reference and incrementally update the solution with further batches (Iodice D'Enza and Greenacre, 2010). This approach, does not take into account the presence of a cluster structure in the set of statistical units. This contribution intend to present an approach that, through the combination of clustering and factorial techniques, aims to visualize the evolution of the association structure of binary attributes over different data batches. The proposal is to introduce a latent categorical variable which is determined and updated at each incoming batch; in other words this variable is determined according to the association structure and represents the 'link' among the solutions. The latent categorical variable is endogenously determined by the procedure; in particular, it refers to the cluster structure characterizing the data set in question. A starting solution is updated incrementally as new data sets are analysed. The factorial display will describe the patterns of change in the multiple associations when shifting the analysis from one occasion to the other. Procedures suitably combining clustering with factorial analysis techniques have been proposed. Vichi and Kiers (2001) propose a combination of principal component analysis (PCA) with k-means clustering method. In the framework of categorical data, another interesting approach combining clustering and multiple correspondence analysis (MCA) is proposed by Hwang et al. (2006). Similarly, yet dealing with binary data, Palumbo and Iodice D'Enza (2010) propose a suitable dimension reduction and clustering. The present proposal is an enhancement of the latter approach to the comparative analysis of multiple batches

An Ultra diffuse Galaxy in the NGC 5846 group from the VEGAS survey

Many ultra diffuse galaxies (UDGs) have now been identified in clusters of galaxies. However, the number of nearby UDGs suitable for detailed follow-up remain rare. Our aim is to begin to identify UDGs in the environments of nearby bright early-type galaxies from the VEGAS survey. Here we use a deep g band image of the NGC 5846 group, taken as part of the VEGAS survey, to search for UDGs. We found one object with properties of a UDG if it associated with the NGC 5846 group, which seems likely. The galaxy, we name NGC 5846$\_$UDG1, has an absolute magnitude of M$_g$ = -14.2, corresponding to a stellar mass of $\sim$10$^8$ M$_{\odot}$. It also reveals a system of compact sources which are likely globular clusters. Based on the number of globular clusters detected we estimate a halo mass that is greater than 8$\times$10$^{10}$ M$_{\odot}$ for UDG1.Comment: 5 pages, 4 figures, accepted for publication in A&

A panoramic VISTA of the stellar halo of NGC 253

Outskirts of large galaxies contain important information about the galaxy formation and assembly process, and resolved star count studies can probe the extremely low surface brightness of the outer halos. We use images obtained with the VISTA telescope to construct spatially resolved J vs Z-J colour-magnitude diagrams (CMDs) of NGC 253, a nearly edge-on disk galaxy in the Sculptor group. The very deep photometry, down to J ~ 23.5, and the wide area covered allows us to trace the red giant branch (RGB) and asymptotic giant branch (AGB) stars that belong to the outer disk and the halo of NGC 253, out to 50 kpc along the galaxy minor axis. We confirm the existence of an extra planar stellar component of the disk, with a very prominent southern shelf and a symmetrical feature on the north side. The only additional visible sub-structure is an overdensity in the north-west part of the halo at about 28 kpc from the plane and extending over ~ 20 kpc parallel with the disk of the galaxy. From the stellar count profile along the major axis we measure the transition from the disk to the halo at a radial distance of about 25 kpc, where a clear break appears in the number density profile. The isodensity contours show that the inner halo is a flattened structure that blends with a more extended, diffuse, rounder outer halo. Such external structure can be traced to the very edge of our image out to 50 kpc from the disk plane. The number density profile of the stars in the stellar halo follows a power law with index -1.6, as function of radius. The CMD shows a very homogeneous stellar population across the whole field; by comparison with theoretical isochrones we conclude that the RGB stars are ~ 8 Gyr old or more, while the AGB stars trace a population of about 2 x 10^8 Mo, formed from ~ 0.5 to a few Gyr ago. Surprisingly, part of this latter population appears scattered over a wide area.Comment: To appear on Astronomy and Astrophysic

The NIR structure of the barred galaxy NGC253 from VISTA

[abridged] We used J and Ks band images acquired with the VISTA telescope as part of the science verification to quantify the structures in the stellar disk of the barred Sc galaxy NGC253. Moving outward from the galaxy center, we find a nuclear ring within the bright 1 kpc diameter nucleus, then a bar, a ring with 2.9 kpc radius. From the Ks image we obtain a new measure of the deprojected length of the bar of 2.5 kpc. The bar's strength, as derived from the curvature of the dust lanes in the J-Ks image, is typical of weak bars. From the deprojected length of the bar, we establish the corotation radius (R_CR=3 kpc) and bar pattern speed (Omega_b = 61.3 km /s kpc), which provides the connection between the high-frequency structures in the disk and the orbital resonances induced by the bar. The nuclear ring is located at the inner Lindblad resonance. The second ring does not have a resonant origin, but it could be a merger remnant or a transient structure formed during an intermediate stage of the bar formation. The inferred bar pattern speed places the outer Lindblad resonance within the optical disk at 4.9 kpc, in the same radial range as the peak in the HI surface density. The disk of NGC253 has a down-bending profile with a break at R~9.3 kpc, which corresponds to about 3 times the scale length of the inner disk. We discuss the evidence for a threshold in star formation efficiency as a possible explanation of the steep gradient in the surface brightness profile at large radii. The NIR photometry unveils the dynamical response of the NGC253 stellar disk to its central bar. The formation of the bar may be related to the merger event that determined the truncation of stars and gas at large radii and the perturbation of the disk's outer edge.Comment: Accepted for publication in Astronomy & Astrphysics. High resolution pdf file is available at the following link: https://www.dropbox.com/s/4o4cofs1lyjrtpv/NGC253.pd

VEGAS: a VST Early-type GAlaxy Survey. IV. NGC 1533, IC 2038 and IC 2039: an interacting triplet in the Dorado group

This paper focuses on NGC 1533 and the pair IC 2038 and IC 2039 in Dorado a nearby, clumpy, still un-virialized group. We obtained their surface photometry from deep OmegaCAM@ESO-VST images in g and r bands. For NGC 1533, we map the surface brightness down to $\mu_g \simeq 30.11$ mag/arcsec$^{2}$ and $\mu_r \simeq 28.87$ mag/arcsec$^{2}$ and out to about $4R_e$. At such faint levels the structure of NGC 1533 appear amazingly disturbed with clear structural asymmetry between inner and outer isophotes in the North-East direction. We detect new spiral arm-like tails in the outskirts, which might likely be the signature of a past interaction/merging event. Similarly, IC 2038 and IC 2039 show tails and distortions indicative of their ongoing interaction. Taking advantages of deep images, we are able to detect the optical counterpart to the HI gas. The analysis of the new deep data suggests that NGC 1533 had a complex history made of several interactions with low-mass satellites that generated the star-forming spiral-like structure in the inner regions and are shaping the stellar envelope. In addition, the VST observations show that also the two less luminous galaxies, IC 2038 and IC 2039, are probably interacting each-other and, in the past, IC 2038 could have also interacted with NGC 1533, which stripped away gas and stars from its outskirts. The new picture emerging from this study is of an interacting triplet, where the brightest galaxy NGC 1533 has ongoing mass assembly in the outskirts.Comment: Accepted for publication in The Astronomical Journal. High-resolution version of paper is available at the following link: https://www.dropbox.com/preview/VEGAS_IV.pdf?role=persona

Phenotypic effects of expanded ataxin-1 polyglutamines with interruptions in vitro

Spinocerebellar ataxia type 1 is a neurodegenerative disease caused by expansion of an uninterrupted glutamine repeat in ataxin-1 protein. Protein aggregation and immunoreactivity to 1C2 monoclonal antibody are two distinct pathognomonic features of expanded ataxin-1, as well as of other polyglutamine disorders. Rare cases of non-affected elderly subjects carrying expanded ataxin-1 alleles were found in random population. However, in these alleles the glutamine stretch was interrupted by histidines. Due to lack of phenotype, these alleles should be considered "normal". Most importantly, occurrence of these unusual alleles provides a unique opportunity to investigate which molecular properties of expanded ataxin-1 are not coupled to polyglutamine pathogenesis. Towards this goal, we compared in vitro the immunoreactivity to 1C2 antibody and the ability to form aggregates of interrupted and uninterrupted alleles. Immunoblotting showed that expanded-interrupted ataxin-1 had an affinity to 1C2 resembling that of normal ataxin-1. On the contrary, filter assay showed that aggregation rate of expanded-interrupted ataxin-1 resembles that of expanded-uninterrupted ataxin-1. These observations indicate that affinity for 1C2 does not directly correlate with self-aggregation of ataxin-1. Moreover, self-aggregation is not directly affected by histidine interruptions. In conclusion, these results support the hypothesis that mechanisms underlying neuronal degeneration are triggered by protein misfolding rather than by protein aggregation