246 research outputs found
Mammalian target of rapamycin signaling activation patterns in neuroendocrine tumors of the lung.
Pressurized intraperitoneal aerosol chemotherapy with cisplatin and doxorubicin or oxaliplatin for peritoneal metastasis from pancreatic adenocarcinoma and cholangiocarcinoma
Background: Systemic chemotherapy for pancreatic adenocarcinoma (PDAC) and cholangiocarcinoma (CC) with peritoneal metastases (PM) is affected by several pharmacological shortcomings and low clinical efficacy. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is expected to maximize exposure of peritoneal nodules to antiblastic agents. This study aims to evaluate safety and efficacy of PIPAC for PM of PDAC and CC origin. Methods: This is a retrospective analysis of consecutive PDAC and CC cases with PM treated with PIPAC at two European referral centers for peritoneal disease. We prospectively recorded from August 2016 to May 2019 demographic, clinical, surgical, and oncological data. We performed a feasibility and safety assessment and an efficacy analysis based on clinical and pathological regression. Results: Twenty patients with PM from PDAC (14) and CC (six) underwent 45 PIPAC administrations. Cisplatin–doxorubicin or oxaliplatin were administered to eight and 12 patients, respectively. We experienced one intraoperative complication (small bowel perforation) and 18 grade 1–2 postoperative adverse events according to Common Terminology Criteria for Adverse Events version 4.0. A pathological regression was recorded in 50% of patients (62% in the cisplatin–doxorubicin cohort and 42% in the oxaliplatin one). Median survival from the first PIPAC was 9.7 and 10.9 months for PDAC and CC, respectively. Conclusion: PIPAC resulted feasible and safe without relevant toxicity issues, with both cisplatin–doxorubicin and oxaliplatin. The pathological response observed supports the evidence of antitumoral activity. Despite the study limitations, these outcomes are encouraging, recommending PIPAC in prospective, controlled trials in the palliative setting or the first line chemotherapy for PM from PDAC and CC
Somatostatin receptor tissue distribution in lung neuroendocrine tumours: a clinicopathologic and immunohistochemical study of 218 'clinically aggressive' cases.
A Non-parametric Approach to Measuring the \kpi{} Amplitudes in \dpkkpi{} Decay
Using a large sample of \dpkkpi{} decays collected by the FOCUS
photoproduction experiment at Fermilab, we present the first non-parametric
analysis of the \kpi{} amplitudes in \dpkkpi{} decay. The technique is similar
to the technique used for our non-parametric measurements of the \krzmndk{}
form factors. Although these results are in rough agreement with those of E687,
we observe a wider S-wave contribution for the \ksw{} contribution than the
standard, PDG \cite{pdg} Breit-Wigner parameterization. We have some weaker
evidence for the existence of a new, D-wave component at low values of the mass.Comment: 13 pages 3 figure
A Study of D0 --> K0(S) K0(S) X Decay Channels
Using data from the FOCUS experiment (FNAL-E831), we report on the decay of
mesons into final states containing more than one . We present
evidence for two Cabibbo favored decay modes, and
, and measure their combined branching fraction
relative to to be = 0.0106
0.0019 0.0010. Further, we report new measurements of
=
0.0179 0.0027 0.0026, = 0.0144 0.0032 0.0016,
and = 0.0208 0.0035 0.0021 where the first error is
statistical and the second is systematic.Comment: 11 pages, 3 figures, typos correcte
Study of Cabibbo Suppressed Decays of the Ds Charmed-Strange Meson involving a KS
We study the decay of Ds meson into final states involving a Ks and report
the discovery of Cabibbo suppressed decay modes Ds -> Kspi-pi+pi+ (179 +/- 36
events) and Ds -> Kspi+ (113 +/-26 events). The branching ratios for the new
modes are Gamma(Ds -> Kspi-pi+pi+)/Gamma(Ds -> KsK-pi+pi+) = 0.18 +/- 0.04 +/-
0.05 and Gamma(Ds -> Kspi+)/Gamma(Ds -> KsK+) = 0.104 +/- 0.024 +/- 0.013.Comment: 11 pages, 6 figure
The S-wave from the decay
Using data from FOCUS (E831) experiment at Fermilab, we present a model
independent partial-wave analysis of the S-wave amplitude from the
decay . The S-wave is a generic complex function to be
determined directly from the data fit. The P- and D-waves are parameterized by
a sum of Breit-Wigner amplitudes. The measurement of the S-wave amplitude
covers the whole elastic range of the system.Comment: 13 pages, 9 figures, submitted to Physics Letters
Search for and Using Genetic Programming Event Selection
We apply a genetic programming technique to search for the double Cabibbo
suppressed decays and .
We normalize these decays to their Cabibbo favored partners and find
\Lambda_c^+ \to p K^+ \pi^-\Lambda_c^+ \to p K^-
\pi^+ and D_s^+ \to K^+ K^+
\pi^-D_s^+ \to K^+ K^- \pi^+ where
the first errors are statistical and the second are systematic. Expressed as
90% confidence levels (CL), we find and respectively.
This is the first successful use of genetic programming in a high energy
physics data analysis.Comment: 10 page
Measurement of the D+ and Ds+ decays into K+K-K+
We present the first clear observation of the doubly Cabibbo suppressed decay
D+ --> K-K+K+ and the first observation of the singly Cabibbo suppressed decay
Ds+ --> K-K+K+. These signals have been obtained by analyzing the high
statistics sample of photoproduced charm particles of the FOCUS(E831)
experiment at Fermilab. We measure the following relative branching ratios:
Gamma(D+ --> K-K+K+)/Gamma(D+ --> K-pi+pi+) = (9.49 +/- 2.17(statistical) +/-
0.22(systematic))x10^-4 and Gamma(Ds+ --> K-K+K+)/Gamma(Ds+ --> K-K+pi+) =
(8.95 +/- 2.12(statistical) +2.24(syst.) -2.31(syst.))x10^-3.Comment: 10 pages, 8 figure
A Non-parametric Approach to the D+ to K*0bar mu+ nu Form Factors
Using a large sample of D+ -> K- pi+ mu+ nu decays collected by the FOCUS
photoproduction experiment at Fermilab, we present the first measurements of
the helicity basis form factors free from the assumption of spectroscopic pole
dominance. We also present the first information on the form factor that
controls the s-wave interference discussed in a previous paper by the FOCUS
collaboration. We find reasonable agreement with the usual assumption of
spectroscopic pole dominance and measured form factor ratios.Comment: 14 pages, 5 figures, and 2 tables. We updated the previous version by
changing some words, removing one plot, and adding two tables. These changes
are mostly stylisti
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