605 research outputs found
Tuning the atomic and domain structure of epitaxial films of multiferroic BiFeO3
Recent works have shown that the domain walls of room-temperature
multiferroic BiFeO3 (BFO) thin films can display distinct and promising
functionalities. It is thus important to understand the mechanisms underlying
domain formation in these films. High-resolution x-ray diffraction and
piezo-force microscopy, combined with first-principles simulations, have
allowed us to characterize both the atomic and domain structure of BFO films
grown under compressive strain on (001)-SrTiO3, as a function of thickness. We
derive a twining model that describes the experimental observations and
explains why the 71o domain walls are the ones commonly observed in these
films. This understanding provides us with a new degree of freedom to control
the structure and, thus, the properties of BiFeO3 thin films.Comment: RevTeX; 4 two-column pages; 4 color figures. Figure 2b does not seem
to display well. A proper version can be found in the source fil
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Cavity electromechanics with parametric mechanical driving
Microwave optomechanical circuits have been demonstrated to be powerful tools for both exploring fundamental physics of macroscopic mechanical oscillators, as well as being promising candidates for on-chip quantum-limited microwave devices. In most experiments so far, the mechanical oscillator is either used as a passive element and its displacement is detected using the superconducting cavity, or manipulated by intracavity fields. Here, we explore the possibility to directly and parametrically manipulate the mechanical nanobeam resonator of a cavity electromechanical system, which provides additional functionality to the toolbox of microwave optomechanics. In addition to using the cavity as an interferometer to detect parametrically modulated mechanical displacement and squeezed thermomechanical motion, we demonstrate that this approach can realize a phase-sensitive parametric amplifier for intracavity microwave photons. Future perspectives of optomechanical systems with a parametrically driven mechanical oscillator include exotic bath engineering with negative effective photon temperatures, or systems with enhanced optomechanical nonlinearities
Evaluation of α,β-unsaturated ketones as antileishmanial agents
In this study, we assessed the antileishmanial activity of 126 α,β-unsaturated ketones. The compounds NC901, NC884, and NC2459 showed high leishmanicidal activity for both the extracellular (50% effective concentration [EC(50)], 456 nM, 1,122 nM, and 20 nM, respectively) and intracellular (EC(50), 1,870 nM, 937 nM, and 625 nM, respectively) forms of Leishmania major propagated in macrophages, with little or no toxicity to mammalian cells. Bioluminescent imaging of parasite replication showed that all three compounds reduced the parasite burden in the murine model, with no apparent toxicity
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Development of Thiophene Compounds as Potent Chemotherapies for the Treatment of Cutaneous Leishmaniasis Caused by Leishmania major
Leishmania major (L. major) is a protozoan parasite that causes cutaneous leishmaniasis. About 12 million people are currently infected with an annual incidence of 1.3 million cases. The purpose of this study was to synthesize a small library of novel thiophene derivatives, and evaluate its parasitic activity, and potential mechanism of action (MOA). We developed a structure–activity relationship (SAR) study of the thiophene molecule 5A. Overall, eight thiophene derivatives of 5A were synthesized and purified by silica gel column chromatography. Of these eight analogs, the molecule 5D showed the highest in vitro activity against Leishmania major promastigotes (EC50 0.09 ± 0.02 µM), with an inhibition of the proliferation of intracellular amastigotes higher than 75% at only 0.63 µM and an excellent selective index. Moreover, the effect of 5D on L. major promastigotes was associated with generation of reactive oxygen species (ROS), and in silico docking studies suggested that 5D may play a role in inhibiting trypanothione reductase. In summary, the combined SAR study and the in vitro evaluation of 5A derivatives allowed the identification of the novel molecule 5D, which exhibited potent in vitro anti-leishmanial activity resulting in ROS production leading to cell death with no significant cytotoxicity towards mammalian cells
Universal Finite Size Scaling Functions in the 3D Ising Spin Glass
We study the three-dimensional Edwards-Anderson model with binary
interactions by Monte Carlo simulations. Direct evidence of finite-size scaling
is provided, and the universal finite-size scaling functions are determined.
Monte Carlo data are extrapolated to infinite volume with an iterative
procedure up to correlation lengths xi \approx 140. The infinite volume data
are consistent with a conventional power law singularity at finite temperature
Tc. Taking into account corrections to scaling, we find Tc = 1.156 +/- 0.015,
nu = 1.8 +/- 0.2 and eta = -0.26 +/- 0.04. The data are also consistent with an
exponential singularity at finite Tc, but not with an exponential singularity
at zero temperature.Comment: 4 pages, Revtex, 4 postscript figures include
The three dimensional Ising spin glass in an external magnetic field: the role of the silent majority
We perform equilibrium parallel-tempering simulations of the 3D Ising
Edwards-Anderson spin glass in a field. A traditional analysis shows no signs
of a phase transition. Yet, we encounter dramatic fluctuations in the behaviour
of the model: Averages over all the data only describe the behaviour of a small
fraction of it. Therefore we develop a new approach to study the equilibrium
behaviour of the system, by classifying the measurements as a function of a
conditioning variate. We propose a finite-size scaling analysis based on the
probability distribution function of the conditioning variate, which may
accelerate the convergence to the thermodynamic limit. In this way, we find a
non-trivial spectrum of behaviours, where a part of the measurements behaves as
the average, while the majority of them shows signs of scale invariance. As a
result, we can estimate the temperature interval where the phase transition in
a field ought to lie, if it exists. Although this would-be critical regime is
unreachable with present resources, the numerical challenge is finally well
posed.Comment: 42 pages, 19 figures. Minor changes and added figure (results
unchanged
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