Changing patient preferences toward better trial recruitment : an ethical analysis

Acknowledgements We thank Luke Gelinas, who participated in our group’s discussions, for his insightful and helpful comments. Funding This work was supported by a project grant from the Canadian Institutes of Health Research (CIHR) (reference number: PJT – 169055).Peer reviewedPublisher PD

Tracing the origins of centrioles, cilia, and flagella

Centrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral structures; they are present in all major eukaryotic groups. Despite the conservation of their core structure, there is variability in their architecture, function, and biogenesis. Recent genomic and functional studies have provided insight into the evolution of the structure and function of these organelles