Amphiphiles containing aromatic groups in the hydrophobic part

Aggregation processes are essential for life on this planet. For example, the membranes of all living cells are bilayered aggregates, consisting of lipid molecules, proteins and steroids. In many biological processes, aggregates play a role. The main driving force for aggregation of amphiphiles is hydrophobic interaction. ... Zie: Summar

Interim Performance Progression (IPP) During Consecutive Season Best Performances of Talented Swimmers

Objective: The main goal of the present study was to investigate the interim performance progression (IPP) of talented swimmers. Part of this group ultimately made it to the top (referred to as elite swimmers) whereas others did not make it to the top (referred to as high-competitive swimmers). Rather than investigating performance progression based solely on season best performances, we included the first swim performance of the season in the metrics of IPP. Knowledge about the IPP of talented swimmers from and toward their season best performances relative to the first swim performance of the season will enhance our understanding of changes in season best performances during the talent trajectory and provide valuable insights for talent development and selection processes in competitive swimming. Methods: Fifteen thousand nine hundred and forty four swim performances (first swim performances of the season and season best performances) between 1993 and 2019 of 3,199 talented swimmers (of whom 556 reached elite level and 2,643 reached high-competitive level) were collected from Swimrankings and related to the prevailing world record of the corresponding sex. The pattern of IPP was represented by two phases: phase A and phase B. Phase A reflected the performance progression between the previous season best performance and the first swim performance of the current season (PPA) and phase B reflected the performance progression between the first swim performance of the current season and the season best performance of the current season (PPB). Depending on the normality check, we used independent sample t-tests or Mann Whitney tests to establish significant differences in PPA and PPB between elite and high competitive swimmers per age category per sex (p &lt; 0.05). Results: Without denying individual differences, male elite swimmers improved more during phase B from age 15 till 24 compared to high-competitive swimmers (20.5% vs. 13.1%, respectively, p &lt; 0.05). Female elite swimmers improved more during phase B from age 13 till 23 compared to high-competitive swimmers (21.1% vs. 14.6%, respectively, p &lt; 0.05). Except for age 14 in males, there were no significant differences between performance groups in PPA. Conclusion: Talented swimmers who ultimately made it to the top (elite swimmers) are characterized with different patterns of IPP compared to talented swimmers who did not make it to the top (high-competitive swimmers). After puberty, elite and high-competitive swimmers performed in general ~1% slower at the start of their season compared to their previous season best performance (PPA). However, elite swimmers improved more in the period between their first swim performance of the season and their season best performance (PPB) from age 13 (females) and age 15 (males) onwards.</p

Perceived health status: is obesity perceived as a risk factor and disease?

One might expect that a perception of obesity being a risk factor and disease, contributes to effective obesity prevention and management strategies. However, obesity rates continue to increase worldwide. The question arises whether obesity is truly perceived as a risk factor and a disease. This paper aims at describing perception of obesity as risk factor and disease among individuals seeking care, individuals not seeking care, the society, and different professionals having a role in the field of obesity. The paper is a reflection of the lecture on the topic that was given at the EASO's New Investigators United's Summer School 2016 in Portugal and the discussion with the new investigators and other senior speakers. Individual obese patients seeking help are very much aware of obesity being a risk factor and disease, but perceptions regarding obesity seem to be flawed among those who do not seek help for obesity. Also, misperceptions regarding obesity play a role at different levels, including society, different political levels, the fields of health care and social work, prevention organizations, and the food and marketing industry. The food and marketing industry has an enormous role in changing perceptions by the society and policy makers. Obesity rates will continue to increase as long as individuals, the society, and professionals at different levels have false interpretations of the severity of obesity. Severe action is needed against those who are playing a role in maintaining false perceptions of obesity as a risk factor and disease.- (undefined

Changes in technique throughout a 1500-m speed skating time-trial in junior elite athletes: Differences between sexes, performance levels and competitive seasons

Speed skating is a technical endurance sport. Still, little is known about technical changes in junior speed skaters. Therefore, changes in technique throughout a 1500-m time-trial of elite junior speed skaters is investigated to explore differences between sexes, performance levels and competitive seasons. At (inter)national 1500-m competitions, knee and push-off angles were obtained for 120 elite junior speed skaters (56 female, 64 male, age 17.6±1.1 years) per lap at 250m (lap 1), 650m (lap 2), 1050m (lap 3) and 1450m (lap 4). Additionally, 1500m end-times and lap-times were obtained to divide skaters in faster and slower performance groups and to analyze pacing behavior. Fifteen skaters (8 female, 7 male, age 17.3 ±1.5 years) were measured again after 1.6±0.6 years. (Repeated measures) ANOVAs were used for statistical analyses (p<0.05). ICC, determined in a pilot study, was 0.55 for knee and 0.76 for push-off angles. Elite junior speed skaters increased their knee angles throughout the race (p<0.005), regardless of sex (p = 0.110) or performance level (p = 0.714). Push-off angles increased from lap 1–3 (p<0.001), in which men showed a larger decay than female skaters (p<0.05), this holds for both performance groups (p = 0.103). Faster skaters had smaller knee and push-off angles than slower skaters (p<0.05). Males showed smaller body angles than females (p<0.001). Faster male and female skaters showed a relative slower start and faster lap 3 compared to slower skaters (p<0.05). Development over competitive seasons showed a shift towards smaller push-off angles (p = 0.038) and less decay in knee angles from lap 2–3 (p = 0.026). The present study shows that technique throughout the 1500m deteriorates. Deterioration in technique is regardless of performance level, even with different pacing behaviors. Differences between sexes were found for push-off angles. The longitudinal development suggests changes in technique towards senior level and highlights the importance of studying juniors separate from seniors

Mapping of quantitative trait loci for flesh colour and growth traits in Atlantic salmon (Salmo salar)

<p>Abstract</p> <p>Background</p> <p>Flesh colour and growth related traits in salmonids are both commercially important and of great interest from a physiological and evolutionary perspective. The aim of this study was to identify quantitative trait loci (QTL) affecting flesh colour and growth related traits in an F2 population derived from an isolated, landlocked wild population in Norway (Byglands Bleke) and a commercial production population.</p> <p>Methods</p> <p>One hundred and twenty-eight informative microsatellite loci distributed across all 29 linkage groups in Atlantic salmon were genotyped in individuals from four F2 families that were selected from the ends of the flesh colour distribution. Genotyping of 23 additional loci and two additional families was performed on a number of linkage groups harbouring putative QTL. QTL analysis was performed using a line-cross model assuming fixation of alternate QTL alleles and a half-sib model with no assumptions about the number and frequency of QTL alleles in the founder populations.</p> <p>Results</p> <p>A moderate to strong phenotypic correlation was found between colour, length and weight traits. In total, 13 genome-wide significant QTL were detected for all traits using the line-cross model, including three genome-wide significant QTL for flesh colour (Chr 6, Chr 26 and Chr 4). In addition, 32 suggestive QTL were detected (chromosome-wide P < 0.05). Using the half-sib model, six genome-wide significant QTL were detected for all traits, including two for flesh colour (Chr 26 and Chr 4) and 41 suggestive QTL were detected (chromosome-wide P < 0.05). Based on the half-sib analysis, these two genome-wide significant QTL for flesh colour explained 24% of the phenotypic variance for this trait.</p> <p>Conclusions</p> <p>A large number of significant and suggestive QTL for flesh colour and growth traits were found in an F2 population of Atlantic salmon. Chr 26 and Chr 4 presented the strongest evidence for significant QTL affecting flesh colour, while Chr 10, Chr 5, and Chr 4 presented the strongest evidence for significant QTL affecting growth traits (length and weight). These QTL could be strong candidates for use in marker-assisted selection and provide a starting point for further characterisation of the genetic components underlying flesh colour and growth.</p