COVID-19 vaccine induced Guillain-Barre syndrome: a case report

Guillain-Barre syndrome (GBS) is a rare immune mediated clinical disorder of the peripheral nerves. A number of vaccines including COVID-19 vaccine have been shown to be associated with an increased risk of GBS. We reported a case of Corbevax® (COVID-19 vaccine) induced GBS. A 12 years old girl presented to the paediatric emergency with 2 days history of progressive weakness of all four limbs. The weakness started after one day of patient received her first dose of Corbevax®. Neurological examination findings were weakness, decreased muscles tone, decreased muscles power, diminished or absent deep tendon reflexes of all four limbs. The findings of cerebrospinal fluid showed increase in protein and normal cell count. The diagnosis of GBS was confirmed by nerve conduction studies. After confirmation of the diagnosis, she was given intravenous immunoglobulin (IVIG) with the dose of 2 g/kg body weight divided over 5 consecutive days. Then the patient was examined, clinical condition was improved dramatically. GBS rarely caused by COVID-19 vaccination. GBS may become life threatening due to respiratory muscles involvement. In about 30% of cases may require admission in Intensive Care Unit and need for mechanical ventilatory support. So careful monitoring is required after administration of COVID-19 vaccine. This case report never discourages the vaccine rollout, but monitoring of evolving data should be carried on by manufacturers and independent authorities coming to a definite conclusion

Location-specific forecast at Sriharikota during the launch of GSLV-F01

The present study was carried out to examine the performance of two high-resolution mesoscale/regional atmospheric models to provide real time short range forecast during the GSLV-F01 launch on 20 September 2004. The main objective was to provide vertical shear of horizontal wind, which is very important for launch operations. The models are integrated to provide forecasts 36 h in advance. The model predictions are compared with observations and their performances are evaluated in terms of statistical skill scores. The mesoscale model of Pennsylvania State University (PSU)/National Center for Atmospheric Research (NCAR) MM5 was found to perform better than the High-resolution Regional Model (HRM) though marginally. Performance of MM5 model was further investigated after improvement of model initial condition with insertion of conventional observations into the large-scale global analysis to perform reanalysis at high resolution (horizontal resolution of 9 km). Results indicate significant improvement in model performance with improvement in initial condition

A case of drug induced oral erythema multiforme

Erythema multiforme (EM) is an acute, self-limited, usually mild, and often relapsing mucocutaneous syndrome. It occurs predominantly in younger age group with slight male preponderance. The classical cutaneous target lesions and mucosal bullae or erosions are clinical manifestations of EM. Drug induced oral EM a rare clinical entity which involves only the lips and oral mucosa without skin involvement. These lesions are difficult in diagnosing with other oral ulcerative lesions with similar clinical manifestations. Here we are reporting a case of phenylbutazone induced oral EM. The causality of phenylbutazone in the reaction was “probable” as per Naranjo scale and seriousness of the reaction was “prolonged hospitalization”. The patient was managed by immediate withdrawal of the suspected drug along with conservative managements to prevent secondary infections. The patient was discharged successfully after 15 days of admission

Assessing groundwater stoichiometric composition and its suitability in northwestern Bangladesh

Groundwater quality analyses included pH, EC, cations (Ca2+, Mg2+, Na+, K+, Zn2+, Cu2+, Mn2+, Fe3+ and As3+), anions (CO32-, HCO3-, NO3-, SO42-, PO43- and Cl-) and TDS of northwestern Bangladesh. The samples contained Ca2+, Mg2+ and Na+ as the dominant cations and HCO3- and Cl- were the dominant anions. Ratios of major cations and anions of water samples suggest the predominance of Ca and Mg-containing minerals over Na-containing minerals. According to TDS and SAR values, all samples were classed as 'freshwater' and 'excellent' categories. The SSP of all waters was under 'excellent' and 'good' classes. All samples were within 'soft' class regarding hardness with 'suitable' RSC. Based on As3+, Zn2+, Mn2+, Fe3+, SO42-, NO3- and Cl- all groundwater samples were within the 'safe' limit for drinking but unsuitable for some industries for specific ions

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

KAMALESWAR KI KAHANIYAM SAMVEDANA AUR SHILP

HINDICUSATDepartment of hindi,CUSA