A pilot trial of an online guided self-help cognitive behavioral therapy program for bulimia nervosa and binge eating disorder in Japanese patients

BackgroundThe purpose of this study was to develop an internet-based Guided Self-Help CBT (iGSH-CBT) for Bulimia Nervosa (BN) / Binge Eating Disorder (BED) for Japanese patients and to test its feasibility.MethodsA single-arm feasibility study. After baseline assessment, patients underwent a 16-week iGSH-CBT program, our Japanese adaption of the European-based Salut BN program. During the treatment period, weekly email support from trained counselors was provided. Evaluations were performed at baseline, after 8 weeks, at the end of the 16-week intervention, and at 2 months after treatment had ended. The primary outcome measure was the change in the weekly frequency of objective binging. Secondary outcomes were the change in the weekly frequency of objective purge episodes, responses on self-report questionnaires of the frequencies of binging and purging, psychopathological characteristics of eating disorders found on BITE, EDE-Q, EDI-2, HADS and EQ-5D, measurements of motivation, and completion of intervention (vs. dropout).ResultsParticipants were 9 female outpatients with BN (n = 5) or BED (n = 4), of whom 8 (88.9%) attended the assessment at the end of the 16-week intervention. Mean age was 28 years (SD = 7.9). Percent change of the weekly frequency of objective binging was -4.40%, and at the end of the 16-week intervention 25% of the participants had achieved symptom abstinence.ConclusionsNo adverse events were observed during the treatment period and follow-up, and the implementation and operation of the program could be performed without any major problems, confirming the feasibility of iGSH-CBT for BN and BED for Japanese patients. Although no significant change was observed in the weekly frequency of objective binging, the abstinence rate from bulimic behaviors of those who completed the assessments was 25.0% at the end of treatment, and the drop-out rate was 11.1%. iGSH-CBT may be an acceptable and possibly even a preferred method of CBT delivery for Japanese patients with BN or BED, and our Japanese adaptation of Salut BN seems feasible.Trial registrationUMIN, UMIN000031962. Registered 1 April 2018 - Retrospectively registered, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R00003633

Difficulties in mastering self-regulation skill and supporting methodologies

Abstract. We consider hierarchical model of skills. Based on the model, we clarify difficulties in mastering each skill, consider which difficulties are reduced by existing supporting method, and then clarify which difficulties remain to master self-regulation skill. In this paper we propose a method of supporting learners

What Do You Mean by to Help Learning of Metacognition?

Abstract. Several computer-based learning support systems and methods help learners to master metacognitive activity. Which systems and methods are designed to eliminate which difficulties associated with the learning of metacognitive activity through its clear specification? We adopt a method in our research that support

What is metacognitive skill? – Collaborative learning strategy to facilitate development of metacognitive skill

Abstract: Recently, how to support development of a learner’s metacognitive skill is one of the most important topics in the research area of educational support systems. However, it is difficult for the researchers in the area to share research findings and reuse them each other, because there is a lack of common vocabulary to represent metacognitive phenomena and shared understandings of them. It causes some confusion in the studies about metacognition and metacognitive skill. In this paper, we provide a common platform towards constructing common vocabulary and shared understandings of them. Then, we introduce our model of metacognitive skill and describe difficulties in learning and executing the skill. Based on our model, we also propose a learning support environment where learners develop their metacognitive skills through collaborative learning

Development of nuclear DNA markers to characterize genetically diverse groups of Misgurnus anguillicaudatus and its closely related species

Repetitive DNA sequences, ManDra and ManBgl, were isolated from the DraI and BglII digests of the genomic DNA of Misgurnus anguillicaudatus, respectively. A primer set of ManDra distinguished two genetically different groups (A and B) of M. anguillicaudatus by specific electrophoretograms. A primer set of ManBgl amplified the DNA of M. anguillicaudatus and M. mizolepis. The individuals of M. anguillicaudatus were divided into two groups depending on the fragment sizes, in which the groups A and B (B-1 and B-2) showed 400 and 460 bp, respectively. M. mizolepis was distinguished by a different pattern (400-, 460-, and 510-bp fragments). PCR-RFLP analyses of recombination activating gene 1 gave a clear difference between A or B-2 (443-bp fragment) and B-1 groups (296- and 147-bp fragments). Clonal lineages and hybrids between B-1 and B-2 groups could be identified by appearance of three fragments (443, 296, and 147 bp). The combined analyses using the above three nuclear markers discriminated among nuclear genomes of genetic groups (A, B-1 and B-2) of M. anguillicaudatus and M. mizolepis. In several localities, natural hybridizations between the group B-1 and B-2 loaches and introgressions of clonal mitochondrial genomes into the group B-1 loaches were detected

Relationships between age and gender differentials in health among older people in China

The objective of this paper is to specify the relationships between age and gender differentials in health among older people in China. The data were drawn from the 2002 Chinese Longitudinal Health Longevity Study (CLHLS), which included 15,789 respondents aged 65 or more years. The health indicators included the Activities of Daily Living (ADL) and Instrumental ADL scores, cognitive ability (using the Mini Mental State Examination), visual function, hearing or auditory function, number of natural teeth, self-reported health, and self-reported quality of life. The statistical significance of the age relationships was examined using Mann-Whitney U tests and Spearman's rank correlation coefficients. The principal results were that above 65 years of age, gender differentials were observed in host of the health indicators at most ages, although self-rated quality of life was an exception. For most of the objective (observer-rated) health indicators, the gender differentials increased with greater age, but that for the number of natural teeth decreased with age. Gender differentials in the two subjective health measures had no significant relationship with age. It is concluded that older Chinese worsen have poorer health than men and are in many ways disadvantaged, and that the relative disadvantage increases with age. Chinese women tend to live longer and surer ill-health more than men

Cytoskeletal and mitochondrial properties of bovine oocytes obtained by Ovum Pick-Up: the effects of follicle stimulation and in vitro maturation

Follicle stimulation by follicular stimulating hormone (FSH) is known to improve developmental competence of bovine oocytes obtained by Ovum Pick-Up (OPU); however, the exact factors in oocytes affected by this treatment have remained unclear. We compared in vitro matured (IVM) oocytes obtained at the immature stage from cows by OPU either without or with stimulation with FSH (non-stimulated and stimulated OPU, respectively) to those obtained by superstimulation and in vivo maturation in terms of cytoskeleton morphology, mitochondrial distribution, intracellular adenosine triphosphate (ATP) content and H_2O_2 levels at the metaphase-II stage and intracellular Ca^ levels after in vitro fertilization (IVF). Confocal microscopy after immunostaining revealed reduced size of the meiotic spindle, associated with increased tendencies of microfilament degradation and insufficient mitochondrial re-distribution in non-stimulated OPU-derived IVM oocytes compared with those collected by stimulated OPU, which in turn resembled in vivo matured oocytes. However, there was no difference in mitochondrial functions between oocytes obtained by stimulated or non-stimulated OPU in terms of ATP content, cytoplasmic H_2O_2 levels, base Ca^ levels and the frequencies and amplitudes of Ca^ oscillations after IVF. Larger size of metaphase spindles in oocytes obtained by stimulated OPU may reflect and potentially contribute to their high developmental competence