Über die Reaktion von Vanillin mit phenolischen Verbindungen

Electron densities at the nucleus of several simple phenols and plant phenols such as catechin and quercetin are calculated by the HMO-method. We found a correlation between the maximum of the electron density at the nucleus and the extinction value of the reaction product with vanillin. With the exception of quercetin an explanation is given by the HMO-calculation. Investigations into the structure of the reaction products have been carried out

Correlation of Age at Oral Contraceptive Pill Start with Age at Breast Cancer Diagnosis

Breast cancer is progressively diagnosed with increasing age. This study aimed to determine whether women who started using the oral contraceptive pill (OCP) at an early age developed breast cancer earlier than women who started using the OCP later in life. A database review of 1,010 breast cancer patients, who had used the OCP at some point in their life, was carried out. Associations of age at OCP start with age at breast cancer diagnosis were determined by multiple linear regression analysis, considering year of birth, year of diagnosis, age at first pregnancy, number of live births, age at menarche, and length of OCP use. There was evidence of a linear trend between age at OCP start and age at breast cancer diagnosis. Women who started using the OCP aged 18 years or younger were, on average, 4 years younger at breast cancer diagnosis than women who started using the OCP over the age of 30 years, and women who started using the OCP aged 22-25 years were, on average, 3 years younger (p-value for trend <0.001). The age when the OCP was started was positively associated with the age when breast cancer was first diagnosed