Peningkatan Efisiensi Pembangkit Listrik Tenaga Surya Dengan Reflektor Parabola

This paper present the result of reserch on improving the solar power plant efficiency using two parabolic reflectors. The designed parabolic reflectors are asymmetrical concentrators placed on a horizontal surface so that radiation from each angle can be collected. Two monocrystalline solar modules, each with 0.639 m length and 0.294 m width are used, which can produce 20.124 W maximum power, 1.3 A short circuit current, and 21.2 V open circuit voltage on 1000 W/m2 solar irradiation and 25 °C temperature. The solar module itself has 10.71% efficiency which is used as the reference efficiency. A solar module with parabolic reflectors can produce 11.13% average efficiency or 1.039 times higher than the reference efficiency. The whole system with two solar modules and parabolic reflectors can produce 13.111 W maximum power and 11.92% highest efficiency or 1.113 times higher than the reference efficiency. Makalah ini merupakan hasil penelitian tentang peningkatan efisiensi pembangkit listrik tenaga surya dengan reflektor parabola. Reflektor parabola yang dirancang berupa konsentrator asimetris yang ditempatkan pada permukaan horizontal agar radiasi dari setiap sudut dapat dikumpulkan. Dua modul surya yang digunakan dari jenis monokristal masing-masing berukuran panjang 0,639 m dan lebar 0,294 m dapat menghasilkan daya maksimum 20,124 W, arus hubung singkat 1,3 A, dan tegangan terbuka 21,2 V pada iradiasi matahari 1000 W/m2 dan temperatur 25 °C. Modul surya sendiri memiliki efisiensi referensi sebesar 10,71 %. Satu modul surya dengan reflektor parabola dapat menghasilkan efisiensi rata-rata 11,13 % atau 1,039 kali lebih tinggi dibandingkan efisiensi referensi. Keseluruhan sistem pembangkit dengan dua modul surya dan reflektor parabola dapat menghasilkan daya maksimum 13,111 W dan efisiensi tertinggi sebesar 11,92 % atau 1,113 kali lebih tinggi dibandingkan efisiensi referensi

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele