Assessment of Safety of Using Antithrombotic Agents during Esophagogastroduodenoscopy : Rationale and Design of the ASAMA Study

This is the first multicenter trial in Japan to investigate the safety of continuing antithrombotic therapy during EGD with biopsy.Article信州医学雑誌 60(3): 143-148(2012)journal articl

How and where satellite cities form around a large city: Bifurcation mechanism of a long narrow economy

We investigate economic agglomerations in a long narrow economy, in which discrete locations are evenly spread over a line segment. The bifurcation mechanism of a monocentric city at the center is analyzed analytically to show how and where satellite cities form. This is an important step to elucidate the mechanism of the competition between a large central city and satellite cities, which is taking place worldwide. By the analysis of the Forslid & Ottaviano (J Econ Geo, 2003) model, we show that the larger the agglomeration forces, the farther from the monocentric city satellite cities emerge. As the trade freeness increases from a low value, there occurs a spatial period doubling in which every other city grows. Thereafter a central city with two satellite cities appears, en route to a complete agglomeration to the central city

Annexin A1 Negatively Regulates Viral RNA Replication of Hepatitis C Virus

Persistent infection with hepatitis C virus (HCV) often causes chronic hepatitis, and then shows a high rate of progression to liver cirrhosis and hepatocellular carcinoma. To clarify the mechanism of the persistent HCV infection is considered to be important for the discovery of new target(s) for the development of anti-HCV strategies. In the present study, we found that the expression level of annexin A1 (ANXA1) in human hepatoma cell line Li23-derived D7 cells was remarkably lower than that in parental Li23 cells, whereas the susceptibility of D7 cells to HCV infection was much higher than that of Li23 cells. Therefore, we hypothesized that ANXA1 negatively regulates persistent HCV infection through the inhibition of viral RNA replication. The results revealed that HCV production was significantly inhibited without a concomitant reduction in the amount of lipid droplets in the D7 cells stably expressing exogenous ANXA1. Further, we demonstrated that ANXA1 negatively regulated the step of viral RNA replication rather than that of viral entry in human hepatocytes. These results suggest that ANXA1 would be a novel target for the development of anti-HCV strategies