Effectiveness of Tetrachlorodecaoxide Compounds in the Healing of Mandibular Fracture

Fractures of mandible are more common in fighting dogs or can be occur due to accidents. A dog with similar fracture was presented at Department of Clinical Medicine and Surgery (CMS) with dropped jaw, drawling of bloody saliva. Animal was reluctant to eat and was depressed. After critical physical examination, the condition was confirmed as bilateral fracture of the mandibular body. After performing the necessary pre-operative test like complete blood count (CBC), Serum biochemistry and urinalysis, fracture was surgically reduced by using inter-dental wiring technique. Tetrachlorodecaoxide drops (TCDO) (Oxoferin®; Brookes Pharmaceutical Laboratories, Pakistan) were applied on fracture site three to four times /day until recovery. Animal was kept on liquid diet (chicken soup and milk) throughout and semi-solid food after 25 days. The fracture healed uneventfully in just 37 days

Peripheral Neuropathy among Patients with Diabetes Mellitus: Use of Douleur Neuropathic Questionnaire

Objective: To find out the prevalence of diabetic peripheral neuropathy in patients with diabetes mellitus. Methodology: It was an observational study conducted on a sample of 150 subjects who were enrolled by a convenient random sampling technique. Patients with a history of diabetes for more than 5 years and of 30-85 years of age from both genders were included. Patients with a history of surgery, frozen shoulder psychological issues, and kidney problems were excluded. Data were collected from Allama Iqbal Memorial Hospital & Islam Central hospital, Sialkot using Douleur neuropathic DN 4 questionnaire, and questions about age, lifestyle, glucose level, hypoesthesia, and gender were added. Data were analyzed by SPSS 20. Results: Out of 150 patients with DM, 49 were males and 101 were females. Active lifestyle was found in 53.33% and 46.67% were physically inactive. Higher glucose levels were found in 53.33% of males and 46.67% of females. In 38 (25.3%) individual's upper limb was involved and in 112 (74.7%) lower limb was involved. Out of 150 subjects, 138 (92%) had a score above 4.0 and thus had peripheral neuropathy. A positive correlation between lifestyle and peripheral neuropathy was found by applying Pearson chi-square and the p-value was 0.000

Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress

In this research work, the antioxidant and metabolomic profiling of seven selected medicinally important herbs including Rauvolfia serpentina, Terminalia arjuna, Coriandrum sativum, Elettaria cardamom, Piper nigrum, Allium sativum, and Crataegus oxyacantha was performed. The in vivo cardioprotective potential of these medicinal plants was evaluated against surgically induced oxidative stress through left anterior descending coronary artery ligation (LADCA) in dogs. The antioxidant profiling of these plants was done through DPPH and DNA protection assay. The C. oxyacantha and T. arjuna showed maximum antioxidant potential, while the E. cardamom showed poor antioxidative strength even at its high concentration. Different concentrations of extracts of the said plants exhibited the protection of plasmid DNA against H2O2 damage as compared to the plasmid DNA merely treated with H2O2. The metabolomic profiling through LC-MS analysis of these antioxidants revealed the presence of active secondary metabolites responsible for their antioxidant potential. During in vivo analysis, blood samples of all treatment groups were drawn at different time intervals to analyze the cardiac and hemodynamic parameters. The results depicted that the group pretreated with HC4 significantly sustained the level of CK-MB, SGOT, and LDH as well as hemodynamic parameters near to normal. The histopathological examination also confirmed the cardioprotective potential of HC4. Thus, the HC4 being safe and inexpensive cardioprotective herbal combination could be considered as an alternate of synthetic drugs

Green Production and Structural Evaluation of Maize Starch–Fatty Acid Complexes Through High Speed Homogenization

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. The current study describes the production of maize starch–fatty acid complexes through high speed homogenization, a novel field of research, without heat or any chemical treatment. The starch–fatty acid complexes were produced with three different fatty acids, i.e. stearic acid (T1), palmitic acid (T2) and lauric acid (T3). The complexes were analyzed through various techniques. The results reveal that the complexing index (CI), swelling power (SP) and solubility (S) for T1 were significantly higher compared to T2 and T3. In X-ray diffraction (XRD) studies, relatively lower crystalline (V-type pattern) structures were obtained for the samples T1–T3, where T2 showed the highest crystallinity amongst all. Fourier transformed infrared (FTIR) spectra showed characteristic bands i.e., OH, C=O, C–O and long-chain CH2 functionalities thus confirming the overall incorporation of acids into glycoside moieties. The Scanning electron microscopy (SEM) analysis showed sub-crystalline matrix structures with fewer or no spherulites indicating the overall incorporation of acids in starch. The samples showed relatively low thermal stability in the thermal gravimetric analysis (TGA) in the range of 180 to 280 °C. These results suggest that high speed homogenization had the potential for the development of green and biocompatible maize starch–fatty acid complexes

Efficacy of Azadirachta indica (Neem) leaf extract and hypertonic saline solution as intratesticular chemical sterilizing agents in dogs

A castração consiste na indução da esterilidade por meio físico, químico ou hormonal. A castração química é uma técnica eficiente e confiável, em contraste com outros procedimentos de esterilização, pois é menos dolorosa para os métodos físicos e econômicos para os métodos hormonais. Azadirachta indica (neem), é uma planta carismática, pois possui folhas anti-inflamatórias, antimicrobianas e antiandrogênicas. Para diminuir a crescente população humana no sul da Ásia, o óleo de nim e o extrato de folhas de nim têm sido efetivamente usados como agente contraceptivo. O principal determinante deste estudo atual foi avaliar o Neem como um agente esterilizante químico (necrótico ou apoptótico) em cães injetados intratesticularmente em comparação com uma solução salina hipertônica. O tamanho da largura testicular pré e pós-injeção e as amostras de sangue para os níveis séricos de testosterona foram colhidas em dias alternados. Os resultados obtidos revelaram alterações substanciais no tamanho da largura testicular, perfil histopatológico e nível sérico de testosterona. Observou-se uma leitura não significativa (P> 0,05) da largura testicular da pré-injeção, em contraste com um aumento significativo (P <0,05) três dias após a injeção em todos os grupos competitivos. Os valores médios registrados para o tamanho da largura testicular no final do estudo via extrato de folhas de nim, HSS a 30% e grupos controle foram 27,7362 ± 2,3315 mm, 30,9594 ± 4,6861 mm e 24,5023 ± 2,5387 mm, respectivamente. Uma tendência decrescente, com relação ao nível sérico de testosterona sendo estatisticamente significante (P <0,05), foi registrada nos grupos tratados (A, B), em contraste com o grupo controle (C), pois os valores eram 1,5357 ± 0,7819ng, 1,2669 ± 0,9095ng e 2,4517 ± 0,1827ng nos grupos A, B e C, respectivamente. Os achados histopatológicos advogaram a presença de corpos apoptóticos no grupo tratado com nim, enquanto a presença de células intersticiais degeneradas, túbulos seminíferos necrosados, epitélio germinativo danificado e espermatogênese interrompida também foi estudada nos dois grupos competitivos. Assim, o efeito apoptótico e a propriedade anti-inflamatória do extrato de folhas de nim resultaram em uma castração menos dolorosa e confirmaram que a Azadirachta indica foi um melhor substituto para a castração química do que a solução salina hipertônica.Castration refers to induced sterility via physical, chemical, or hormonal methods. Chemical castration is an efficient and reliable technique in contrast to other sterilization procedures as it is less painful to physical methods and cost‑effective to hormonal methods. Azadirachta indica (neem), is a charismatic plant as its leaves possess anti-inflammatory, anti‑microbial, and anti-androgenic chattels. To abate the escalating human population in South Asia, neem oil and neem leaf extract have been effectively used as a contraceptive agent. The key determinant of the current study was to evaluate Neem as a chemical sterilizing agent, (either necrotic or apoptotic), in dogs injected intratesticular in comparison to a hypertonic saline solution. Pre- and post-injection testicular width size and blood samples for serum testosterone levels were collected on alternative days. Results disclosed substantial changes in testicular width size, histopathological profile, and serum testosterone level. A non-significant (P > 0.05) pre-injection testicular width readings in contrast to a significant increase (P < 0.05) three days post-injection was noted in all the competitive groups. The mean values recorded for testicular width size at the end of the trial study via neem leaf extract, 30% HSS and, control groups were 27.7362 ± 2.3315mm, 30.9594 ± 4.6861mm, and 24.5023 ± 2.5387mm, respectively. A declining trend, regarding serum testosterone level being statistically significant (P < 0.05) was recorded in treated groups (A, B) in contrast to the control group (C) as the values were 1.5357 ± 0.7819ng, 1.2669 ± 0.9095ng, and 2.4517 ± 0.1827ng in groups A, B, and C, respectively. Histopathological findings advocated the presence of apoptotic bodies in the neem treated group whereas the presence of degenerated interstitial cells, necrosed seminiferous tubules, damaged germinal epithelium, and ceased spermatogenesis was also studied in both competitive groups. Thus, the apoptotic effect and anti-inflammatory property of neem leaf extract resulted in less painful castration and verified Azadirachta indica as a better substitute for chemical castration in contrast to hypertonic saline solution

Simulation of magnetic dipole and dual stratification in radiative flow of ferromagnetic Maxwell fluid

Theoretical investigation is performed to explore the novel aspects of nonlinear thermal radiation and non-uniform heat source/sink for chemically reactive flow of ferromagnetic Maxwell liquid over a permeable stretching sheet. Buongiorno model is employed to include Brownian motion and thermophoresis effects. The novelty of the existing study is to account the effect of binary chemical reaction, viscous dissipation, thermal and solutal stratification for ferromagnetic Maxwell fluid. Governing system of nonlinear partial differential equations is transformed into a system of nonlinear ordinary differential equations with the help of apposite similarity transformations. The acquired resulting nonlinear ODEs are solved numerically with the assistance built-in-shooting method (bvp4c). Effects of emanating variables are examined through graphs and tables. It is evident that heat transfer rate enhances with thermal radiation. It is analyzed that temperature upsurges for greater estimations of thermal radiation (N1∗), ferromagnetic (βˆ2) and thermophoresis (Nˆt) parameters however it declines for Prandtl number (Pr) and thermal stratified parameter (S₁). Space and temperature dependent heat sinks are more appropriate for cooling purposes

Nonlinear convective stratified flow of Maxwell nanofluid with activation energy

The aim of present article is to explore the novel aspects of activation energy in nonlinearly convective flow of Maxwell nanofluid driven by nonlinearly stretched inclined cylinder. Generalized forms of Fourier's and Fick's law are utilized through Cattaneo-Christov double diffusion scheme. Maxwell nanomaterial model is used to describe the significant slip mechanism namely known as Brownian and thermophoresis diffusions. Features of double stratification, non-uniform heat generation/absorption, binary chemical reaction and activation energy are considered for present flow problem. Modified Arrhenius formula for activation energy is implemented. The resulting nonlinear system is cracked for series solutions via homotopy technique. Effects of different flow parameters on temperature, nanoparticle volume concentration and velocity fields are examined through graphs and tables. Numerical computations are performed for local Nusselt and Sherwood numbers. Our analysis reveals that nanoparticle concentration is directly proportional to the chemical reaction with activation energy. Moreover stratification variables diminish the temperature and concentration. It is also noticed that higher estimation of Deborah number declines the velocity profile of Maxwell fluid. Numerical outcomes are compared with previous published results and found to be in good agreement for limiting cases of the evolving parameters

Effectiveness of Tetrachlorodecaoxide Compounds in the Healing of Mandibular Fracture

Fractures of mandible are more common in fighting dogs or can be occur due to accidents. A dog with similar fracture was presented at Department of Clinical Medicine and Surgery (CMS) with dropped jaw, drawling of bloody saliva. Animal was reluctant to eat and was depressed. After critical physical examination, the condition was confirmed as bilateral fracture of the mandibular body. After performing the necessary pre-operative test like complete blood count (CBC), Serum biochemistry and urinalysis, fracture was surgically reduced by using inter-dental wiring technique. Tetrachlorodecaoxide drops (TCDO) (Oxoferin®; Brookes Pharmaceutical Laboratories, Pakistan) were applied on fracture site three to four times /day until recovery. Animal was kept on liquid diet (chicken soup and milk) throughout and semi-solid food after 25 days. The fracture healed uneventfully in just 37 days

Mixed convective stagnation point flow of nanofluid with Darcy-Fochheimer relation and partial slip

Here axisymmetric mixed convective, stagnation point flow of electrically conducting nanofluid by a permeable cylinder is examined. Magnetic field in transverse direction is applied. The Darcy-Forchheimer relation is accounted to specify the flow nature in porous medium. Formulation of mathematical model is given by using Tiwari-Das nanofluid model. The velocity and thermal slip conditions.are taken. This whole communication comprises water as a base fluid with nano-sized particles (Aluminum oxide, Copper and Titanium Oxide). The nonlinear coupled ordinary differential equations are obtained after using appropriate transformations. The convergent series solution of nonlinear system is accomplished by homotopic approach. The nondimensional velocity and temperature curve are examined under the impact of physical parameters like the nanoparticle volume fraction, permeability parameter, curvature parameter, the magnetic parameter and the mixed convection parameter. Numeric values of coefficient of skin friction and Nusselt number are analyzed. Keywords: Darcy-Forchheimer flow, Tiwari-Das nanofluid model, Stagnation-point flow, Mixed convection, MHD, Slip conditions, HA