QTL mapping for physiology, yield and plant architecture traits in cotton (Gossypium hirsutum L.) grown under well-watered versus water-stress conditions

Increasing scarcity of irrigation water is a major threat to sustainable production of cotton (Gossypium hirsutum L.). Identifying genomic regions contributing to abiotic stress tolerance will help develop cotton cultivars suitable for water-limited regions through molecular marker-assisted breeding. A molecular mapping F2 population was derived from an intraspecific cross of the drought sensitive G. hirsutum cv. FH-901 and drought tolerant G. hirsutum cv. RH-510. Field data were recorded on physiological traits (osmotic potential and osmotic adjustment); yield and its component traits (seedcotton yield, number of bolls/plant and boll weight); and plant architecture traits (plant height and number of nodes per plant) for F2, F2:3 and F2:4 generations under well-watered versus water-limited growth conditions. The two parents were surveyed for polymorphism using 6500 SSR primer pairs. Joinmap3.0 software was used to construct linkage map with 64 polymorphic markers and it resulted into 35 markers mapped on 12 linkage groups. QTL analysis was performed by composite interval mapping (CIM) using QTL Cartographer2.5 software. In total, 7 QTLs (osmotic potential 2, osmotic adjustment 1, seedcotton yield 1, number of bolls/plant 1, boll weight 1 and plant height 1) were identified. There were three QTLs (qtlOP-2, qtlOA-1, and qtlPH-1) detected only in water-limited conditions. Two QTLs (qtlSC-1 and qtlBW-1) were detected for relative values. Two QTLs (qtlOP-1 and qtlBN-1) were detected for well-watered treatment. Significant QTLs detected in this study can be employed in MAS for molecular breeding programs aiming at developing drought tolerant cotton cultivars

Fabrication Challenges in Synthesizing Porous Ceramic Membrane to Effective Flue Gas Treatment

Global warming is a serious concern worldwide, while there are many contributors to rise the temperature of earth. One major source to it, is air pollution. It is of utmost importance to apply the necessary remedial actions to address the contaminants in outdoor and indoor environment. In this research a step is taken to treat flue gases, for which membrane technology is introduced. A porous ceramic membrane is synthesized from calcined porous alumina (Al2O3) and activated washed fly ash. Some other additives like starch (C6H10O5) n, binder solution along with ethyl silicate (C8H2O4Si) and a deflocculating agent carbonic acid (H2CO3), are employed. Alongside it, some of the issues are discussed which are faced during fabrication of porous ceramic membrane i.e., crakes in membrane sample, non-active reactants issue, un-even rise or fall during de-moisturization or sintering steps. Further, the membrane sample is characterized through different test including:  Further, the membrane sample is characterized through different test including thermogravimetric analysis (TGA) and DTG, which shown a satisfactory results, as there is negligible percentage weight loss after 750°C. X-ray fluorescence (XRF) for fly ash portrayal and X-ray diffraction (XRD) analysis for structure assessing are conducted, which described that the fabricated membrane has a crystalline structure as like ceramic. Archimedes Principal technique is used to determine bulk density, and porosity of the membrane sample, the values are 4.484 g/cm3, and 62.5% respectively. Average pore size of 7.6 µm is find out through optical microscopy test, similarly mechanical strength is found to be 2.7 MPa. Furthermore, a pilot scale visual permeability test is performed for flue gases treatment of combusting fuel containing tyre and coal powder. The results show the compatibility of the fabricated porous ceramic membrane to be utilized for treatment of flue gases

Chemical insights into the synthetic chemistry of five-membered saturated heterocycles—a transition metal–catalyzed approach

Drug design and delivery is primarily based on the hunt for new potent drug candidates and novel synthetic techniques. Recently, saturated heterocycles have gained enormous attention in medicinal chemistry as evidenced by the medicinal drugs listed in the FDA Orange Book. Therefore, the demand for novel saturated heterocyclic syntheses has increased tremendously. Transition metal (TM)–catalyzed reactions have remained the prime priority in heterocyclic syntheses for the last three decades. Nowadays, TM catalysis is well adorned by combining it with other techniques such as bio- and/or enzyme-catalyzed reactions, organocatalysis, or using two different metals in a single catalysis. This review highlights the recent developments of the transition metal–catalyzed synthesis of five-membered saturated heterocycles

An innovative decision-making framework for supplier selection based on a hybrid interval-valued neutrosophic soft expert set

The best way to achieve sustainable construction is to choose materials with a smaller environmental impact. In this regard, specialists and architects are advised to take these factors into account from the very beginning of the design process. This study offers a framework for selecting the optimal sustainable building material. The core goal of this article is to depict a novel structure of a neutrosophic soft expert set hybrid called an interval-valued neutrosophic soft expert set for utilization in construction supply chain management to select a suitable supplier for a construction project. This study applies two different techniques. One is an algorithmic technique, and the other is set-theoretic. The first one is applied for the structural characterization of an interval-valued neutrosophic expert set with its necessary operators like union and OR operations. The second one is applied for the construction of a decision-making system with the help of pre-described operators. The main purpose of the algorithm is to be used in supply chain management to select a suitable supplier for construction. This paper proposes a new model based on interval-valued, soft expert and neutrosophic settings. In addition to considering these settings jointly, this model is more flexible and reliable than existing ones because it overcomes the obstacles of existing studies on neutrosophic soft set-like models by considering interval-valued conditions, soft expert settings and neutrosophic settings. In addition, an example is presented to demonstrate how the decision support system would be implemented in practice. In the end, analysis, along with benefits, comparisons among existing studies and flexibility, show the efficacy of the proposed structure

Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

BACKGROUND: The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. METHODS: We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends. FINDINGS: In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of −0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = −0.41), inflammatory bowel disease (AAPC = −0.72), multiple sclerosis (AAPC = −0.26), psoriasis (AAPC = −0.77), and atopic dermatitis (AAPC = −0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR. INTERPRETATION: The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rheumatoid arthritis and upsurging new cases of other five IMIDs, respectively. FUNDING: The Global Burden of Disease Study is funded by the Bill and Melinda Gates Foundation. The project funded by Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (2022QN38)

Global, regional, and national incidence of six major immune-mediated inflammatory diseases : findings from the global burden of disease study 2019

DATA SHARING STATEMENT : Data used for the analyses are publicly available from the Institute of Health Metrics and Evaluation (http://www.healthdata.org/; http:// ghdx.healthdata.org/gbd-results-tool).BACKGROUND : The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. METHODS : We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends. FINDINGS : In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of −0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = −0.41), inflammatory bowel disease (AAPC = −0.72), multiple sclerosis (AAPC = −0.26), psoriasis (AAPC = −0.77), and atopic dermatitis (AAPC = −0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR. INTERPRETATION : The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rheumatoid arthritis and upsurging new cases of other five IMIDs, respectively.The Global Burden of Disease Study is funded by the Bill and Melinda Gates Foundation. Support from Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital; Shaqra University; the School of Pharmacy, University of Botswana; the Indian Council of Medical Research (ICMR); an Australian National Health and Medical Research Council (NHMRC) Investigator Fellowship; the Italian Center of Precision Medicine and Chronic Inflammation in Milan; the Department of Environmental Health Engineering of Isfahan University of Medical Sciences, Isfahan, Iran; National Health and Medical Research Council (NHMRC), Australia; Jazan University, Saudi Arabia; the Clinician Scientist Program of the Clinician Scientist Academy (UMEA) of the University Hospital Essen; AIMST University, Malaysia; the Department of Community Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India; a Kornhauser Research Fellowship at The University of Sydney; the National Research, Development and Innovation Office Hungary; Taipei Medical University; CREATE Hope Scientific Fellowship from Lung Foundation Australia; the National Institute for Health and Care Research Manchester Biomedical Research Centre and an NIHR Clinical Lectureship in Respiratory Medicine; Kasturba Medical College, Mangalore and Manipal Academy of Higher Education, Manipal; Author Gate Publications; the Cleveland Clinic Foundation and Nassau University Medical center; the Italian Ministry of Health (RRC); King Abdulaziz University (DSR), Jeddah, and King Abdulaziz City for Science & Technology (KACSAT), Saudi Arabia, Science & Technology Development Fund (STDF), and US-Egypt Science & Technology joint Fund: The Academy of Scientific Research and Technology (ASRT), Egypt; partially supported by the Centre of Studies in Geography and Spatial Planning; the International Center of Medical Sciences Research (ICMSR), Islamabad Pakistan; Ain Shams University and the Egyptian Fulbright Mission Program; the Belgian American Educational Foundation; Health Data Research UK; the Spanish Ministry of Science and Innovation, Institute of Health Carlos III, CIBERSAM, and INCLIVA; the Clinical Research Development Unit, Imam Reza Hospital, Mashhad University of Medical Sciences; Shaqra University; Saveetha Institute of Medical and Technical Sciences and SRM Institute of Science and Technology; University of Agriculture, Faisalabad-Pakistan; the Chinese University of Hong Kong Research Committee Postdoctoral Fellowship Scheme; the institutional support of the Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Egypt; the European (EU) and Developing Countries Clinical Trials Partnership, the EU Horizon 2020 Framework Programme, UK-National Institute for Health and Care Research, the Mahathir Science Award Foundation and EU-EDCTP.http://www.thelancet.comam2024School of Health Systems and Public Health (SHSPH)SDG-03:Good heatlh and well-bein

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

The Precept: Replacing Rigidity with Leniency Its Meaning, Basis, and Limits along with its Scope and Analogy in Pakistani Law

This article discusses how Islamic shariah recommends opting for the easier path i.e. to prefer ease instead of hardship The Messenger of Allah and his blessed companions have always taken the easier path. They have always tried to create ease for the people. This legal maxim and its application in Islamic law is being considered in this article

Inequalities in Islamic State and Society: A Critical Review on the Thoughts of Bernard Lewis

Islam and the West are two competitor civilizations of 21st century. West is much fear by the rapid expansion of Islam. It is imagined that very soon Islam is going to become a major religion of the Europe. Now European think tanks are constantly working to present a negative picture of Islam. Bernard Lewis is trying his best to prove that Islam is not a suitable civilization and religion for the world. As there are different classes of citizens within Islamic State and society and all the citizens are not equal in Islamic teachings and practice like women, slaves and Non-Muslims. Whereas, his presented theories are quite different than real teachings and practice of Islam. All the citizens of Islamic State are equal before law but there is difference of responsibilities according to their abilities. This article is presenting a critical and real discussion about the social inequalities blamed by Bernard Lewis, existing in Islamic state and society

Theory of Deconstruction: A Comparative Study of the Views of Western and Muslim Theorists and Philosophers

This research paper deals with the theory of deconstruction, as enunciated by French abstruse theorist and philosopher Jacques Derrida. This notable theory is considered to be one of the most significant theories of Postmodernism, a literary and philosophical trend that is famous for its distrust of ideologies and theories whatsoever and stresses the importance of conventions. This literary and philosophical theory challenges our perceived notions regarding text and their meanings by emphasizing the fact that language is nothing but a chain of signifiers. In other words, it means that meanings of a text–worldly or transcendental–are not stable ones; they are unstable and transient. Though this theory has gained much power and prestige in the realm of literature and philosophy; however, this theory has been castigated both by Muslim and Western philosophers and theorists, too. This paper is a humble effort to analyze the views of some well-known and veteran Muslim and Western theorists and philosophers. [Artikel ini bersepakat dengan teori dekonstruksi yang dikenalkan oleh filosof Prancis Jacques Derrida. Sebagai salah satu teori yang penting dalam teori-teori posmodern, kepopulerannya dalam sastra dan filsafat menggoyahkan ideologi dan teori lain serta menekankan pentingnya konvensi umum. Teori sastra dan filsafatnya menantang apa yang sudah kita yakini tentang teks dan makna dengan menekankan fakta bahwa bahasa bukan apa apa selain rangkain pertanda. Dengan kata lain, makna sebuah teks, imanen atau transenden, adalah tidak tetap, mereka labil dan sementara. Walaupun teori ini mendapat posisi kuat dan prestisius dalam sastra dan filsafat, namun disangsikan oleh beberapa pemikir muslim dan barat. Artikel ini merupakan usaha menganalisa pandangan mereka mengenai teori dekonstruksi, baik dari pemikir muslim dan barat.