Mirandesa breed calves: growth performance and carcass characterization affected by sex and livestock production system

12 páginas, 8 tablas, 2 figuras.-- Under License of Creative Commons Attribution 3.0 LicenseThe effect of sex and livestock production system (LPS) on growth performance and carcass characteristics of Mirandesa breed calves was studied. A total of 2,263 and 60 animals for growth performance and carcass characteristics, respectively were used. Initially, the suitability of several equations to describe the growth of cattle from the Mirandesa variety was studied. In all situations, mathematical models were formulated with parameters of clear biological meaning. Bertalanffy and Gompertz equations were the most satisfactory equations to model the growth of males and females, respectively. Calves from traditional system were 68.61 kg heavier than animals from extensive system. On the other hand, calves from traditional systems showed (P<0.01) higher dressing percentage compared to animals from extensive system. There were significant differences for all morphometric parameters by LPS effect with the exception of internal depth pf chest, whereas sex effect had less importance. The LPS had statistically significant effect in all individual joints in the front quarter and hind quarter with the exception of sirloin and eye of round for front quarter and shoulder and the sum of chuck plus neck in the hind quarter. Finally, the LPS had statistically significant effect in all components of fifth quarter, with the exception of intestines, liver, tail and spleen, whereas sex effect only affected heart proportionPeer reviewe

Paediatric out-of-hospital resuscitation in an area with scattered population (Galicia-Spain)

<p>Abstract</p> <p>Background</p> <p>Cardiorespiratory arrest (CRA) is a rare event in childhood. Our objective was to determine the characteristics of paediatric CRA and the immediate results of cardiopulmonary resuscitation (CPR) in Galicia, a community with a very scattered population.</p> <p>Methods</p> <p>All children (aged from newborn to 16 years old) who suffered an out-of-hospital CRA in Galicia and were assisted by the Public Foundation Medical Emergencies of Galicia-061 staff, from June 2002 to February 2005, were included in the study. Data were prospectively recorded following the Utstein's style guidelines.</p> <p>Results</p> <p>Thirty-one cases were analyzed (3.4 CRA annual cases per 100.000 paediatric population). The arrest was respiratory in 16.1% and cardiac in 83.9% of cases. CRA occurred at home in 58.1% of instances. Time CRA to initiation of CPR was shorter than 10 minutes in 32.2% and longer than 20 minutes in 29.0% of cases. 22.6% of children received bystander CPR. The first recorded rhythm was asystole in 67.7% of cases. Bag-mask ventilation was used in 67.7% and in 83.8% oro-tracheal intubation was done. A peripheral venous access was achieved in 67.7% and intraosseous access was used in 16.1% of patients. 93.5% of children were treated with adrenaline. After initial CPR, sustained restoration of spontaneous circulation was achieved in 38.7% of cases. Six children (19.4%) survived until hospital discharge. Four of 5 children with respiratory arrest survived, whereas only 2 of 26 children with cardiac arrest survived until hospital discharge.</p> <p>Conclusion</p> <p>Despite the handicap of a highly disseminated population, paediatric CRA characteristics and CPR results in Galicia are comparable to references from other communities. Programs to increase bystander CPR, equip laypeople with basic CPR skills and to update life support knowledge of health staff are needed to improve outcomes.</p

Results of the introduction of an automated external defibrillation programme for non-medical personnel in Galicia

Objectives: To describe the plan and development of a programme for the introduction of automated external defibrillation for non medical personnel and to report the results of the first 10 months of activity in a community which is predominently rural, such as Galicia. Methods: The plan for introduction of the project included aspects of logistics, training and control. We studied cardiac arrests, that were treated in basic life support ambulances (BLS-A) equipped with automated external defibrillators (AEDs), from 1st March to 31st December 2001. Results: Our community benefits from pioneering legislation in Spain. During the 10 months of study, 28 AEDs were in service, mostly in urban areas. In all cases, a thorough control of the quality of the service in which AEDs was used was carried out. 12% of the patients, who were victims of sudden cardiac death (SCD) and were found in ventricular fibrillation (VF), survived and were discharged from hospital. However, the percentage of patients found in VF is only around 26%. This is due to long assistance intervals (from the call to the arrival on site), and an important delay from the moment when circulatory collapse takes place until the emergency service 061 is called, more than 5 min in half the cases. Conclusions: The programme followed for the introduction of AEDs in Galicia was adapted to the socio-demographic characteristics of the population. The prehospital emergency assistance model was developed, executed and controlled by the Public Emergency Health Foundation of Galicia 061 (PEHF-061). The overall results of our first 10 months experience with the automated external defibrillation programme were as to be expected. In general, they are comparable to other published reports; however, ways of shortening the times from the point of collapse to defibrillation must be found, mainly by training the population and through the extension of automated external defibrillation provision to other first responders

Spanish Research Report for 1999

14 páginas, 18 tablasPeer reviewe

Spanish Research Report for 2002

26 páginas, 24 tablasPeer reviewe

Spanish Research Report for 2003

24 páginas, 22 tablasPeer reviewe

Spanish Research Report for 2000

24 páginas, 1 figura, 20 tablasPeer reviewe

PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer

In recent years, poly (ADP-ribose) polymerase (PARP) inhibitors have been evaluated for treating homologous recombination-deficient tumours, taking advantage of synthetic lethality. However, increasing evidence indicates that PARP1 exert several cellular functions unrelated with their role on DNA repair, including function as a co-activator of transcription through protein-protein interaction with E2F1. Since the RB/E2F1 pathway is among the most frequently mutated in many tumour types, we investigated whether the absence of PARP activity could counteract the consequences of E2F1 hyperactivation. Our results demonstrate that genetic ablation of Parp1 extends the survival of Rb-null embryos, while genetic inactivation of Parp1 results in reduced development of pRb-dependent tumours. Our results demonstrate that PARP1 plays a key role as a transcriptional co-activator of the transcription factor E2F1, an important component of the cell cycle regulation. Considering that most oncogenic processes are associated with cell cycle deregulation, the disruption of this PARP1-E2F1 interaction could provide a new therapeutic target of great interest and a wide spectrum of indicationsThis work received financial support from the Ministerio de Ciencia e Innovación (SAF2008-00543 and SAF2009-08629; J.A.C.) and ISCIII, Ministerio de Economía y Competitividad (PI15/01129), the Consellería de Cultura, Educación e Ordenación Universitaria (GPC2014/030, INCITE08PXIB208091PR and PXIB208091PR; J.A.C.), PRE/2011/131 (I.G.C.), the Centro Singular de Investigación de Galicia accreditation 2016–2019, ED431G/05), and the European Regional Development Fund (ERDF)S

Resultados de la implantación en Galicia de la desfibrilación semiautomática por personal no médico

Objetivos: Describir el planteamiento y desarrollo de un programa de implantación de desfibrilación semiautomática para personal no médico y mostrar los resultados de los primeros meses de actividad en una comunidad eminentemente rural, como es el caso de Galicia. Métodos : Exposición del plan elegido para la implantación con sus aspectos logísticos, formativos y de control. Se examinan las paradas cardiorrespiratorias atendidas por las ambulancias de soporte vital básico equipadas con desfibriladores semiautomáticos, desde el 1 de marzo hasta el 31 de diciembre de 2001. Resultados : Se posee una legislación completa pionera en nuestro país. Actualmente se cuenta con 58 DESA en funcionamiento y 27 en previsión de implantación inmediata. Se han formado 967 TTS, el 85% del total de los existentes en la comunidad autónoma. En el 100% de los casos se ha realizado un exhaustivo control de calidad del servicio en el que se ha usado el DESA. El 12% de los pacientes víctimas de una muerte súbita y que son encontrados en fibrilación ventricular sobreviven y son dados de alta del hospital; sin embargo, el porcentaje de pacientes que se encuentran en fibrilación ventricular es sólo de un 26%, lo cual traduce por un lado tiempos de asistencia largos (desde la llamada hasta la llegada al punto), pero sobre todo un retraso importante desde que se produce el colapso circulatorio hasta que se llama al 061, más de 5 minutos en la mitad de los casos. Conclusiones: El programa seguido para la implantación de la DESA en Galicia ha sido adecuado a las características socio-demográficas de su población y al modelo de asistencia urgente extrahospitalario desarrollado, ejecutado y controlado por la FPUS-061. Los resultados globales de nuestros10 primeros meses del programa de desfibrilación semiautomática son los esperados y, en general, comparables a los publicados; sin embargo, deben desarrollarse maneras de acortar los tiempos desde el colapso hasta la desfibrilación, principalmente con formación a la población y mediante la extensión de la desfibrilación semiautomática a otros colectivos