5 research outputs found
Population structure of <i>Citrus tristeza virus</i> from field Argentinean isolates
Get PDFWe studied the genetic variability of three genomic regions (p23, p25 and p27 genes) from 11 field Citrus tristeza virus isolates from the two main citrus growing areas of Argentina, a country where the most efficient vector of the virus, Toxoptera citricida, is present for decades. The pathogenicity of the isolates was determinated by biological indexing, single-strand conformation polymorphism analysis showed that most isolates contained high intra-isolate variability. Divergent sequence variants were detected in some isolates, suggesting re-infections of the field plants. Phylogenetic analysis of the predominant sequence variants of each isolate revealed similar grouping of isolates for genes p25 and p27. The analysis of p23 showed two groups contained the severe isolates. Our results showed a high intra-isolate sequence variability suggesting that re-infections could contribute to the observed variability and that the host can play an important role in the selection of the sequence variants present in these isolates.Instituto de Biotecnología y Biología Molecula
Eligibility criteria for Menopausal Hormone Therapy (MHT): a position statement from a consortium of scientific societies for the use of MHT in women with medical conditions. MHT Eligibility Criteria Group
Get PDFThis project aims to develop eligibility criteria for menopausal hormone therapy (MHT). The tool should be
similar to those already established for contraception A consortium of scientific societies coordinated by the
Spanish Menopause Society met to formulate recommendations for the use of MHT by women with medical conditions based on the best available evidence. The project was developed in two phases. As a first step, we
conducted 14 systematic reviews and 32 metanalyses on the safety of MHT (in nine areas: age, time of menopause
onset, treatment duration, women with thrombotic risk, women with a personal history of cardiovascular
disease, women with metabolic syndrome, women with gastrointestinal diseases, survivors of breast cancer or of
other cancers, and women who smoke) and on the most relevant pharmacological interactions with MHT. These
systematic reviews and metanalyses helped inform a structured process in which a panel of experts defined the
eligibility criteria according to a specific framework, which facilitated the discussion and development process.
To unify the proposal, the following eligibility criteria have been defined in accordance with the WHO international
nomenclature for the different alternatives for MHT (category 1, no restriction on the use of MHT;
category 2, the benefits outweigh the risks; category 3, the risks generally outweigh the benefits; category 4,
MHT should not be used). Quality was classified as high, moderate, low or very low, based on several factors
(including risk of bias, inaccuracy, inconsistency, lack of directionality and publication bias). When no direct
evidence was identified, but plausibility, clinical experience or indirect evidence were available, "Expert opinion"
was categorized. For the first time, a set of eligibility criteria, based on clinical evidence and developed according
to the most rigorous methodological tools, has been defined. This will provide health professionals with a
powerful decision-making tool that can be used to manage menopausal symptoms
Early angiosperm diversification: evidence from southern South America
Get PDFIn this report, we analyze the angiosperm fossil record (micro- and megafossil) from the central and southern basins of Argentina, southern South America, deposited between the late Barremian (128.3 Ma) to the end of the Coniacian (85.8 Ma). Based on this analysis, three major stages in the evolution of the angiosperms in the southernmost region of South America are established as follows: the late Barremian-Aptian, the latest Aptian-earliest Albian, and the middle Albian- Coniacian. The comparison between our fossil data set and those from Australia, North America, Asia and Europe suggest that the evolution and diversification of the angiosperms at mid and high latitudes in both hemispheres occurred roughly synchronously.Fil: Archangelsky, Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; ArgentinaFil: Barreda, Viviana Dora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; ArgentinaFil: Passalia, Mauro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Gandolfo, Maria. Cornell University; Estados UnidosFil: Pramparo, Mercedes Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Romero, Edgardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; Argentina. Museo Paleontológico Egidio Feruglio; ArgentinaFil: Cúneo, Néstor Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Museo Paleontológico Egidio Feruglio; ArgentinaFil: Zamuner, Alba Berta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Área Paleobotánica; ArgentinaFil: Iglesias, Ari. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Área Paleobotánica; ArgentinaFil: Llorens, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comision Nacional de Energia Atomica. Regional Patagonia; ArgentinaFil: Puebla, Gabriela Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Quattrocchio, Mirta Elena. Universidad Nacional del Sur. Departamento de Geología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; ArgentinaFil: Volkheimer, Wolfang. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentin
