54 research outputs found
Flash generation and borylation of 1-(trifluoromethyl)vinyllithium toward synthesis of α-(trifluoromethyl)styrenes
Thermally unstable (3,3,3-trifluoroprop-1-en-2-yl)lithium was generated by lithiation of 2-bromo-3,3,3-trifluoroprop-1-ene and successively underwent borylation in a flow microreactor system. Direct use of the 1-(trifluoromethyl)vinylborate thus formed for the SuzukiâMiyaura coupling in a batch system afforded α-(trifluoromethyl)styrenes in high yields
Ni-Catalyzed Synthesis of Fluoroarenes via [2+2+2] Cycloaddition Involving α-Fluorine Elimination
A method for direct synthesis of tetrasubstituted fluoroarenes via nickel-catalyzed [2+2+2] cycloaddition is presented. The reaction combines one molecule of 1,1-difluoroethylene with two molecules of alkynes and involves sequential cleavage of the C[BOND]F and C[BOND]H bonds in difluoroethylene. The catalytic cycle is established by reduction of the intermediary NiII fluoride with a triethylborane-based borate
Nickel-Catalyzed Alkyl-Alkyl Cross-Couplings of Fluorinated Secondary Electrophiles: A General Approach to the Synthesis of Compounds having a Perfluoroalkyl Substituent
ChemInform Abstract: A Versatile Difluorovinylation Method: Cross-Coupling Reactions of the 2,2-Difluorovinylzinc-TMEDA Complex with Alkenyl, Alkynyl, Allyl, and Benzyl Halides.
ChemInform Abstract: Double C-F Bond Activation Through ÎČ-Fluorine Elimination: Nickel-Mediated [3 + 2] Cycloaddition of 2-Trifluoromethyl-1-alkenes with Alkynes.
Atom-Economical Synthesis of NâArylamides Utilizing Isopropenyl Esters with Heterogeneous Acid Catalysts
Pd/CuâCatalyzed Enantioselective Sequential Heck/Sonogashira Coupling: Asymmetric Synthesis of Oxindoles Containing Trifluoromethylated Quaternary Stereogenic Centers
Pd/CuâCatalyzed Enantioselective Sequential Heck/Sonogashira Coupling: Asymmetric Synthesis of Oxindoles Containing Trifluoromethylated Quaternary Stereogenic Centers
Nickel-Catalyzed Allylic C(sp<sup>3</sup>)âF Bond Activation of Trifluoromethyl Groups via ÎČâFluorine Elimination: Synthesis of Difluoro-1,4-dienes
The
nickel-catalyzed defluorinative coupling of 2-trifluoromethyl-1-alkenes
and alkynes with the aid of Et<sub>3</sub>SiH provides 1,1-difluoro-1,4-dienes
under mild reaction conditions. This reaction involves selective allylic
CÂ(sp<sup>3</sup>)âF bond activation via ÎČ-fluorine elimination
from nickelacyclopentenes
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