Evaluation of frequency of isolation and trends in antibiotic resistance among campylobacter isolates over 11 year period

Objective: To analyze frequency of isolation and trends in antibiotic resistance among Campylobacter isolates over 11 year period in Microbiology Laboratory, Aga Khan University from the year 1992-2002. Methods: Total 52,777 stool specimens were processed during the study period. Enteric pathogens isolated from 8,483 stool samples were further analyzed for frequency of isolation and antimicrobial resistance. Statistical Analysis was done by using descriptive statistics of SPSS version 10. Values were expressed as percentages, mean and rates. Results: Campylobacter species were third in frequency of isolation with an isolation rate of 24.8%. C. jejuni was the predominant pathogen followed by C.coli. Isolation rate of Campylobacter was higher (45.7%) among children under 2 years of age as compared to other age groups. A steady rise in resistance among Campylobacter isolates against ampicillin; tetracycline and ofloxacin has been noted whereas resistance against erythromycin remained fairly low. Conculsion: The isolation of Campylobacter is higher from stool specimens of children of less than two years of age rendering Campylobacteriosis to be an important cause of gastroenteritis in pediatric population. This study also demonstrates a steady rise in antibiotic resistance in Campylobacter isolates especially against quinolones with fall in resistance against erythromycin throughout the study period

Pseudobinary Fe4Ti3S8 compound with a NiAs-type structure: Effect of Ti for Fe substitution

The transition metal sulfide Fe4Ti3S8 with 7:8 composition has been synthesized and studied by using X-ray diffraction, magnetization and electrical resistivity measurements. This compound exhibits a monoclinic crystal lattice (space group I12/m1). The substitution of Ti for Fe in Fe7S8 is found to result in a lowering of the Curie temperature (TC ≈ 205 K), in a larger value of the coercive field (Hc ∼ 9 kOe at low temperatures) and in a substantial growth of the resultant magnetic moment per formula unit (μFU) in comparison with Fe7S8. An enhanced value of μFU is attributed to the preferential substitution of Ti in alternating cation layers. From the paramagnetic susceptibility measured within temperature interval (250-350) K, a reduced value of the effective moment per iron (μFe ∼ 2.4μB) was determined. The electrical resistivity of Fe4Ti3S8 shows a non-metallic behavior and is affected by magnetic ordering. © 2013 Elsevier Masson SAS. All rights reserved

On the EDM Cancellations in D-brane models

We analyze the possibility of simultaneous electron, neutron, and mercury electric dipole moment (EDM) cancellations in the mSUGRA and D--brane models. We find that the mercury EDM constraint practically rules out the cancellation scenario in D-brane models whereas in the context of mSUGRA it is still allowed with some fine-tuning.Comment: 10 pages, to appear in Phys. Rev. Let

Knowledge of recommended dietary cholesterol allowance in an academic community

This study was designed to assess the plasma cholesterol level and consumer awareness of recommended dietary cholesterol allowance in an academic environment. A total of 100 structured questionnaires were randomly distributed within Babcock University community, Ilisan Remo, Ogun State, Nigeria. Ninety seven (97) completed questionnaires were retrieved. Venous blood samples of 60 volunteered participants were also collected for biochemical assays involving plasma levels of total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, triglyceride and glucose concentrations. Results showed that 53(54.6%), 75(77.3%) and 74(76.3%) of the females, nonvegetarians and respondents in sciences, respectively had previous knowledge of the term “dietary cholesterol”. Females 34(35.1%), non-vegetarians 48(49.5%) and respondents in sciences 50(51.5%), respectively were aware of the negative effect of excess dietary cholesterol consumption. In addition, 35(36.1%), 64(66%) and 40(41.2%) of females, non- vegetarians and respondents in sciences consumed poultry eggs at least once a week. Males 35(36.1%), females 35(36.1%), nonvegetarians 54(55.7%) and respondents in sciences 61(62.9%) had never checked their blood cholesterol level. Males 31(32%), non-vegetarian 47(48.5%) and respondents in sciences 40(42.2%) were not aware of the recommended dietary cholesterol allowance and they ate fried foods and confectionaries sometimes. Further study revealed that mean plasma total cholesterol (141.73 ± 20.51 mg/dl), LDLcholesterol (69.80 ± 9.86 mg/dl), triglyceride (209.16 ± 15.58 mg/dl), and glucose (52.27 ± 7.94 mg/dl) concentrations in males were slightly elevated compared to the total cholesterol (141.36 ± 9.75 mg/dl), triglyceride (205.43 ± 6.55 mg/dl), LDLcholesterol (55.52 ± 4.03 mg/dl) and glucose (48.93 ± 3.18 mg/dl) concentrations in females while HDL-cholesterol concentrations of males (30.10 ± 11.96 mg/dl) were significantly lower (P<0.05) compared to those of females (44.75 ± 9.21 mg/dl). Plasma lipid and glucose concentrations of the respondents under the normal body weight category were significantly low (P<0.05) compared to those in overweight and obese body weight categories. Thus, this investigation indicated an inadequate level of awareness and practice of the recommended dietary cholesterol allowance among the educated.Key words: Cholesterol, diet, glucose, knowledge, institution

A T-odd asymmetry in neutralino production and decay

We study CP-violating effects in neutralino production and subsequent decay within the Minimal Supersymmetric Standard Model with complex parameters M_1 and mu. The observable we propose is a T-odd asymmetry based on a triple product in neutralino production e^+ e^- -> tilde{chi}^0_i tilde{chi}^0_2, i = 1,...,4, with subsequent leptonic three-body decay tilde{chi}^0_2 -> tilde{chi}^0_1 l^+ l^-, l = e, mu, at an e^+ e^- linear collider with sqrt{s} = 500 GeV and polarised beams. We provide compact analytical formulae for the cross section and the T-odd asymmetry taking into account the complete spin correlations between production and decay. We give numerical predictions for the cross section and the T-odd asymmetry. The asymmetry can go up to 10 %.Comment: 28 pages, LaTeX, 10 figures; v2: typos corrected, published versio

Synthesis of New Series of Pyrazoline, and Study their Kinetics and Reaction Mechanism

A new series of novel pyrazoline compounds were synthesized by addition of thiosemicarbazide to the 2,6-dibenzylidenecyclohexanone (Chalcone) and its para substituted derivatives. This study was conducted for four purposes. Firstly, a series of five membered ring pyrazoline compounds were synthesized and the structure of all new products obtained are supported by spectral data (1H-NMR, 13CNMR, IR and UV-Vis.), and the effect of substituents were studied. Secondly, the reaction kinetics of the new synthesized compounds were studied to investigate the reaction mechanism pathway and order of the reaction; it was found that, the reaction undergoes via Claisen route of mechanism with first-order reaction. Thirdly, the thermodynamics of the reaction were studied, the rate of the reaction, Arrhenius parameters (A), and thermodynamic parameters for activation includes (free energies (Ea), entropies (ΔS#), and Gibbs free energy (ΔG#) were estimated. Finally, the compensation effect was also studied, and found the same pathway for all of the synthesized pyrazoline compounds

Variational Methods in Sensitivity Analysis and Optimization for Aerodynamic Applications

Variational methods (VM) sensitivity analysis, which is the continuous alternative to the discrete sensitivity analysis, is employed to derive the costate (adjoint) equations, the transversality conditions, and the functional sensitivity derivatives. In the derivation of the sensitivity equations, the variational methods use the generalized calculus of variations, in which the variable boundary is considered as the design function. The converged solution of the state equations together with the converged solution of the costate equations are integrated along the domain boundary to uniquely determine the functional sensitivity derivatives with respect to the design function. The determination of the sensitivity derivatives of the performance index or functional entails the coupled solutions of the state and costate equations. As the stable and converged numerical solution of the costate equations with their boundary conditions are a priori unknown, numerical stability analysis is performed on both the state and costate equations. Thereafter, based on the amplification factors obtained by solving the generalized eigenvalue equations, the stability behavior of the costate equations is discussed and compared with the state (Euler) equations. The stability analysis of the costate equations suggests that the converged and stable solution of the costate equation is possible only if the computational domain of the costate equations is transformed to take into account the reverse flow nature of the costate equations. The application of the variational methods to aerodynamic shape optimization problems is demonstrated for internal flow problems at supersonic Mach number range. The study shows, that while maintaining the accuracy of the functional sensitivity derivatives within the reasonable range for engineering prediction purposes, the variational methods show a substantial gain in computational efficiency, i.e., computer time and memory, when compared with the finite difference sensitivity analysis

Development Of Al-B-C Master Alloy Under External Fields

This study investigates the application of external fields in the development of an Al-B-C alloy, with the aim of synthesizing in situ Al3BC particles. A combination of ultrasonic cavitation and distributive mixing was applied for uniform dispersion of insoluble graphite particles in the Al melt, improving their wettability and its subsequent incorporation into the Al matrix. Lower operating temperatures facilitated the reduction in the amount of large clusters of reaction phases, with Al3BC being identified as the main phase in XRD analysis. The distribution of Al3BC particles was quantitatively evaluated. Grain refinement experiments reveal that Al-B-C alloy can act as a master alloy for Al-4Cu and AZ91D alloys, with average grain size reduction around 50% each at 1wt%Al-1.5B-2C additions