Correlation between visual function and refractive, topographic, pachymetric and aberrometric data in eyes with keratoconus

AIM: To analyze the relationship between two visual functions and refractive, topographic, pachymetric and aberrometric indicators in eyes with keratoconus. METHODS: Corrected distance visual acuity (CDVA), and letter contrast sensitivity (CS) were correlated with refraction, corneal topography, pachymetry, and total corneal wavefront data prospectively in 71 eyes with keratoconus. The topographic indices assessed were simulated keratometry for the flattest and steepest meridians (SimK1 and SimK2), posterior steeper K (Ks), elevation value in best-fit sphere (BFS) maps, squared eccentricity (E-2), aspheric asymmetric index (AAI), pachymetry, thickness progression index (TPI), the amount of pachymetric decentralization (APD), and GalileiTM-keratoconus indices. RESULTS: The mean CDVA (expressed as logMAR) were 0.25 +/- 0.21. The mean CS was 1.25 +/- 0.46. The spherical refraction correlated well with CDVA (r=-0.526, P<0.001). From topographic indices, SRI correlated with CS (r=-0.695), and IAI with CS (r=-0.672) (P<0.001 for all). Root mean square (RMS) was 4.3 +/- 1.81 mu m, spherical aberration (SA) was -0.4 +/- 0.67 mu m, vertical and horizontal coma were -2.1 +/- 1.47 and -0.4 +/- 0.72 mu M. All wavefront data (except horizontal coma), AAI, E-2 and maximum BFS correlated significantly with the visual function (P <= 0.001 for all). CONCLUSION: In this study, CS is more affected than CDVA as a visual function. The quantity and quality of vision is significantly correlated with well-known and new topographic indices. There is not a significant correlation between visual function and pachymetric parameters. The significantly correlated indices can be used in staging keratoconus and to follow the outcome of a treatment.Ziemer Ophthalmic Systems AG, Port, SwitzerlandAnkara Numune Training & Res Hosp, Dept Ophthalmol, TR-06170 Ankara, TurkeyGazi Univ, Sch Med, Dept Ophthalmol, TR-06500 Ankara, TurkeyUniv Fed Sao Paulo, Paulista Sch Med, Dept Ophthalmol, Inst Vis,Ocular Bioengn Sect, BR-05508060 Sao Paulo, Brazil[Arce, Carlos G.] Univ Fed Sao Paulo, Paulista Sch Med, Dept Ophthalmol, Inst Vis,Refract Surg Sect, BR-05508060 Sao Paulo, Brazil[Arce, Carlos G.] Zeimer Grp AG, Allmendstr 11, CH-2562 Port, SwitzerlandUniv Fed Sao Paulo, Paulista Sch Med, Dept Ophthalmol, Inst Vis,Ocular Bioengn Sect, BR-05508060 Sao Paulo, BrazilWeb of Scienc

Correlation between visual function and refractive, topographic, pachymetric and aberrometric data in eyes with keratoconus

AIM: To analyze the relationship between two visual functions and refractive, topographic, pachymetric and aberrometric indicators in eyes with keratoconus. METHODS: Corrected distance visual acuity (CDVA), and letter contrast sensitivity (CS) were correlated with refraction, corneal topography, pachymetry, and total corneal wavefront data prospectively in 71 eyes with keratoconus. The topographic indices assessed were simulated keratometry for the flattest and steepest meridians (SimK1 and SimK2), posterior steeper K (Ks), elevation value in best-fit sphere (BFS) maps, squared eccentricity (E-2), aspheric asymmetric index (AAI), pachymetry, thickness progression index (TPI), the amount of pachymetric decentralization (APD), and GalileiTM-keratoconus indices. RESULTS: The mean CDVA (expressed as logMAR) were 0.25 +/- 0.21. The mean CS was 1.25 +/- 0.46. The spherical refraction correlated well with CDVA (r=-0.526, P<0.001). From topographic indices, SRI correlated with CS (r=-0.695), and IAI with CS (r=-0.672) (P<0.001 for all). Root mean square (RMS) was 4.3 +/- 1.81 mu m, spherical aberration (SA) was -0.4 +/- 0.67 mu m, vertical and horizontal coma were -2.1 +/- 1.47 and -0.4 +/- 0.72 mu M. All wavefront data (except horizontal coma), AAI, E-2 and maximum BFS correlated significantly with the visual function (P <= 0.001 for all). CONCLUSION: In this study, CS is more affected than CDVA as a visual function. The quantity and quality of vision is significantly correlated with well-known and new topographic indices. There is not a significant correlation between visual function and pachymetric parameters. The significantly correlated indices can be used in staging keratoconus and to follow the outcome of a treatment

Caffeic acid phenethyl ester to inhibit posterior capsule opacification in rabbits

Purpose: To assess whether caffeic acid phenethyl ester (CAPE) prevents posterior capsule opacification (PCO) by suppressing the transformation of the lens epithelial cells

Weill-Marchesani syndrome in three generations

Background Weill-Marchesani syndrome is a rare systemic connective tissue disorder consisting of brachymorphy, brachydactyly, ectopia lentis, spherophakia and glaucoma