Morbidity of viral hepatitis B and the results of combating it in the Republic of Moldova

Viral hepatitis B remain to be a global, social and medical problem, including for the Republic of Moldova, where the morbidity due to this infection is higher in comparison with other countries in Europe. This article discusses the results of the preventive measures, especially vaccination, for viral hepatitis B, taken during the last years. In the prevaccination period the number of cases registered annually among children of 0-2 years old vary from 419 in 1986 to 296 in 1989 (the year of the start of the incomplete selective vaccination), while the index of morbidity vary respectively from 1,6o /oo up to 1,2o /oo. The annual average number in the prevaccination period amounted to 343 cases and the incidence rate – to 1,38o /oo. The index of the morbidity in the second period decreased respectively from 1,1o /oo to 0,62o /oo. The average number of the reported cases in this period amounted to 150, and the morbidity rate – to 0,71o /oo. Due to the absence of the vaccine the newborn children resumed getting the universal vaccination only in the autumn of 1994. In the third period the incidence decreased from 70 cases in 1995 (the year of the start of total complete vaccination) to 2 cases in 2006. The indices of the morbidity in this period were, respectively, 0,39o /oo and 0,02o /oo. The annual average number was 14 cases, and the index of morbidity – 0,11o/oo. Thus, we can conclude that the vaccination of newborns and other risk groups is a very effective preventive measure and its further realization as well as nonspecific preventive measures will contribute from year to year to a significant reduction of the morbidity, and to the replacement of the current generation highly affected by the virus HB by another generation little affected by it

Уровень инфицирования вирусом гепатита В беременных женщин в разных географических зонах Республики Молдова

Scientific Laboratory of the Virus Hepatities Epidemiology, National Center of Public HealthThe article shows the results of laboratory investigations on markers of HBV of pregnant women from different geographical areas of Moldova. Six hundred and sity-four pregnant women were examined and were found to be positive on HBsAg marker 33 (5.0 ± 0.4%), anti-HBs - 197 (29.7 ± 3.6%) and anti-HBc - 181 (27.3 ± 3.4%). The highest infection index was determined in pregnant women in the South - HBsAg - 10.0 ± 4.6% and 61.8 ± anti-HBc 7.6%. These indices gave rise to the argumentation of including in National Program for combating Hepatitis B, C and D on this project years 2007-2011 and the years 2012-2016 the vaccination of women of childbearing age as potential sources of infection to new infants. В статье показаны результаты лабораторных исследований беременных женщин из различных географических районов Молдовы на маркеры ВГБ. В целом по Республике были исследовны сыворотки от 664 беременных женщин. Оказалось, что положительный маркер HBsAg был у 33 (5,0 ± 0,4%), анти-HBs - 197 (29,7 ± 3,6%) и анти-HBc - 181 (27,3 ± 3,4%). Самый высокий показатель инфекции был определен у беременных женщин с Юга - HBsAg - 10,0 ± 4,6% и 61,8 ± анти-HBc 7,6%. Эти показатели легли в основу аргументов для включения в Национальную программу борьбы против гепатита В, С и D на 2007-2011 годы и Проекта программы на 2012-2016 годы, вакцинации женщин детородного возраста в качестве потенциальных источников инфекции для новорожденных

Rezultatele testării bolnavilor şi colaboratorilor din secția de hemodializă a SCR la unii markeri ai virusurilor hepatitelor virale В şi C

Summary. It is, that patients and medical staff haemodialysis department are group of risk hepatitis contaminations serum on tokens of a virus hepatitis of 80 patiens (from them 42 - men, and 38 - women) and 29 - medical staff of haemodialysis section was investigated. The results of investigation show, that during the process of haemodialysis the contamination by a virus hepatitis C take place in 81,3% and HBsAg-in 16,3% of cases. A considerable part of them are infected by mixt-infection. Medical staff during their professional work infected with the virus hepatitis C in 20,7% of cases, and by virus hepatitis В in 65,5 % of cases. It is recommended the realization of the non-specific guidelines and also bacterination against the hepatitis В as patients, and medical staff