Immunotherapy and its development for gynecological (Ovarian, endometrial and cervical) tumors: From immune checkpoint inhibitors to chimeric antigen receptor (car)-T cell therapy

Gynecological tumors are malignancies with both high morbidity and mortality. To date, only a few chemotherapeutic agents have shown efficacy against these cancer types (only ovarian cancer responds to several agents, especially platinum-based combinations). Within this context, the discovery of immune checkpoint inhibitors has led to numerous clinical studies being carried out that have also demonstrated their activity in these cancer types. More recently, following the development of chimeric antigen receptor (CAR)-T cell therapy in hematological malignancies, this strategy was also tested in solid tumors, including gynecological cancers. In this article, we focus on the molecular basis of gynecological tumors that makes them potential candidates for immunotherapy. We also provide an overview of the main immunotherapy studies divided by tumor type and report on CAR technology and the studies currently underway in the area of gynecological malignancies

Effect of previous exhaustive exercise on metabolism and fatigue development during intense exercise in humans

The present study examined how metabolic response and work capacity are affected by previous exhaustive exercise. Seven subjects performed an exhaustive cycle exercise ( approximately 130%-max; EX2) after warm-up (CON) and 2 min after an exhaustive bout at a very high (VH; approximately 30 s), high (HI; approximately 3 min) or low (LO; approximately 2 h) intensity. Compared with CON, performance during EX2 was reduced (P<0.05) more in HI and LO than in VH (61+/-4% and 68+/-3% vs 35+/-4%). The muscle glycogen before EX2 was lower (P<0.05) in LO than in HI and VH, but the muscle glycogen utilization rates during EX2 were not different. Muscle glycogen concentration before EX2 was related (P<0.05) to the mean rate of muscle glycogen utilization during EX2 in HI and VH, and the mean rate of muscle lactate accumulation in LO. In HI, muscle pH before EX2 was lower (P<0.05) compared with VH and LO, but the same in HI and VH at the end of EX2. In HI, muscle pH before and after EX2 was inversely related (P<0.05) to the decrease in EX2 performance. Thus, muscle glycogen availability and low muscle pH do not per se control but appear to affect the rate of glycogenolysis/glycolysis and fatigue development during a repeated high-intensity exercise lasting 1/2-2 min

Leveraging autoencoders in change vector analysis of optical satellite images

Various applications in remote sensing demand automatic detection of changes in optical satellite images of the same scene acquired over time. This paper investigates how to leverage autoencoders in change vector analysis, in order to better delineate possible changes in a couple of co-registered, optical satellite images. Let us consider both a primary image and a secondary image acquired over time in the same scene. First an autoencoder artificial neural network is trained on the primary image. Then the reconstruction of both images is restored via the trained autoencoder so that the spectral angle distance can be computed pixelwise on the reconstructed data vectors. Finally, a threshold algorithm is used to automatically separate the foreground changed pixels from the unchanged background. The assessment of the proposed method is performed in three couples of benchmark hyperspectral images using different criteria, such as overall accuracy, missed alarms and false alarms. In addition, the method supplies promising results in the analysis of a couple of multispectral images of the burned area in the Majella National Park (Italy)