Single and Multiple Phase Shifts Tilted Fiber Bragg Gratings

The spectral behavior of single and multiple phase shifts tilted fiber Bragg gratings has been experimentally investigated. To this aim, a simple and cost-effective postprocessing technique based on local thermal treatment was used to create arbitrary phase shifts along the tilted grating structure. In particular, UV written tilted fiber Bragg gratings were treated by the electric arc discharge to erase the refractive index modulation in well-defined regions. We demonstrate that these defects give rise to interference pattern for all modes, and thus defect states can be achieved within all the attenuation bands, enabling a simple wavelength independent spectral tailoring of this class of devices

Arc-Induced Long Period Gratings in Erbium-Doped Fiber

In this paper, we report about the fabrication of long period gratings (LPGs) directly into an Erbium-doped fiber, by using the electric arc discharge technique. The attention is focused on the writing process and the resulting properties, by considering gratings with different periods and measuring their spectra over a wide wavelength range. The LPGs show high order attenuation bands with tunable resonance wavelengths and depths up to 30 dB, while the lengths of the final devices are in range 20-45 mm. The polarization-dependent loss of these LPGs is also measured, for the first time in this kind of fiber. As further novelty, the influence of surrounding refractive index, applied strain, and temperature is investigated and discussed in comparative manner. Based on the achieved results, this fabrication procedure can be adapted to a specific application, for example in optical communications, signal processing, and sensing fields

Temperature profile of ex-vivo organs during radio frequency thermal ablation by fiber Bragg gratings.

We report on the integration of fiber optic sensors with commercial medical instrumentation for temperature monitoring during radio frequency ablation for tumor treatment. A suitable configuration with five fiber Bragg grating sensors bonded to a bipolar radio frequency (RF) probe has been developed to monitor the area under treatment. A series of experiments were conducted on ex-vivo animal kidney and liver and the results confirm that we were able to make a multipoint measurement and to develop a real-time temperature profile of the area, with a temperature resolution of 0.1°C and a spatial resolution of 5 mm during a series of different and consecutive RF discharges

Radicalizzazione e carcere: i primi risultati di una ricerca europea,

Descrizione e primi risultati di SERENY (Strengthening approaches for the prevention of youth radicalisation in prison and probationsettings ), progetto biennale di ricerca cofinanziato dal Programma Giustizia dell’Unione Europea. Il team di ricerca interdisciplinare proveniente da Austria, Italia, Slovenia, Spagna, Albania, Francia e Belgio sta sviluppando strumenti, linee guida e raccomandazioni per sostenere l’efficace attuazione di pratiche di prevenzione della radicalizzazione giovanile rispettose dei diritti umani dei giovani detenuti, in linea con gli standard internazionali e dell’UE

Multipoint temperature monitoring of microwave thermal ablation in bones through fiber bragg grating sensor arrays

Bones are a frequent site of metastases that cause intolerable cancer-related pain in 90% of patients, making their quality of life poor. In this scenario, being able to treat bone oncology patients by means of minimally invasive techniques can be crucial to avoid surgery-related risks and decrease hospitalization times. The use of microwave ablation (MWA) is gaining broad clinical acceptance to treat bone tumors. It is worth investigating temperature variations in bone tissue undergoing MWA because the clinical outcomes can be inferred from this parameter. Several feasibility studies have been performed, but an experimental analysis of the temperature trends reached into the bone during the MWA has not yet been assessed. In this work, a multi-point temperature study along the bone structure during such treatment is presented. The study has been carried out on ex vivo bovine femur and tibia, subjected to MWA. An overall of 40 measurement points covering a large sensing area was obtained for each configuration. Temperature monitoring was performed by using 40 fiber Bragg grating (FBGs) sensors (four arrays each housing 10 FBGs), inserted into the bones at specific distances to the microwave antenna. As result, the ability of this experimental multi-point monitoring approach in tracking temperature variations within bone tissue during MWA treatments was shown. This study lays the foundations for the design of a novel approach to study the effects of MWA on bone tumors. As consequence, the MWA treatment settings could be optimized in order to maximize the treatment effects of such a promising clinical application, but also customized for the specific tumor and patient

Deflection Monitoring Method Using Fiber Bragg Gratings Applied to Tracking Particle Detectors

This paper proposes the use of fiber Bragg gratings (FBGs) for the deflection monitoring of a micromegas (MM) tracking particle detector to be installed at the European Organization for Nuclear Research during a major upgrade of the experiment ATLAS within 2018. MM detectors are designed to reach high spatial and time resolution, even if the design is not yet finalized. One mandatory issue for the MM detector is a precise monitoring of the deflection of the drift and read-out electrodes and/or of the panel hosting the electrodes. To this aim, FBG strain sensors are proposed and experimentally investigated as a sensing solution to monitor the strain state of the detector support panel hosting the drift and read-out electrodes. Finally, simple postprocessing analysis based on classical beam theory considering a rigid body permits calculating the panel deflection. Preliminary experimental results on first prototypes of small and large detector panels are presented and discussed

Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells

AIMS/HYPOTHESIS: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. Here we sought to evaluate the possible role of endoplasmic reticulum (ER) stress in the induction of insulin resistance by glucosamine in skeletal muscle cells. METHODS: Real-time RT-PCR analysis, 2-deoxy-D: -glucose (2-DG) uptake and western blot analysis were carried out in rat and human muscle cell lines. RESULTS: In both rat and human myotubes, glucosamine treatment caused a significant increase in the expression of the ER stress markers immunoglobulin heavy chain-binding protein/glucose-regulated protein 78 kDa (BIP/GRP78 [also known as HSPA5]), X-box binding protein-1 (XBP1) and activating transcription factor 6 (ATF6). In addition, glucosamine impaired insulin-stimulated 2-DG uptake in both rat and human myotubes. Interestingly, pretreatment of both rat and human myotubes with the chemical chaperones 4-phenylbutyric acid (PBA) or tauroursodeoxycholic acid (TUDCA), completely prevented the effect of glucosamine on both ER stress induction and insulin-induced glucose uptake. In both rat and human myotubes, glucosamine treatment reduced mRNA and protein levels of the gene encoding GLUT4 and mRNA levels of the main regulators of the gene encoding GLUT4 (myocyte enhancer factor 2 a [MEF2A] and peroxisome proliferator-activated receptor-gamma coactivator 1alpha [PGC1alpha]). Again, PBA or TUDCA pretreatment prevented glucosamine-induced inhibition of GLUT4 (also known as SLC2A4), MEF2A and PGC1alpha (also known as PPARGC1A). Finally, we showed that overproduction of ATF6 is sufficient to inhibit the expression of genes GLUT4, MEF2A and PGC1alpha and that ATF6 silencing with a specific small interfering RNA is sufficient to completely prevent glucosamine-induced inhibition of GLUT4, MEF2A and PGC1alpha in skeletal muscle cells. CONCLUSIONS/INTERPRETATION: In this work we show that glucosamine-induced ER stress causes insulin resistance in both human and rat myotubes and impairs GLUT4 production and insulin-induced glucose uptake via an ATF6-dependent decrease of the GLUT4 regulators MEF2A and PGC1alpha

Rapporto sugli eventi sismici del Beneventano

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