159 research outputs found
Functions of "Home" in Occupational Socialization Process : Life Histories of People from an Okinawan Community
Water and Energy Exchanges at Forests and a Grassland in Eastern Siberia Evaluated using a One-dimensional Land Surface Model
Seasonal variation of heat fluxes over tundra near Tiksi, Siberia (Session 3: In-site Flux Observation studies)
Structures of the Sea‐Breeze Front in Dual‐Doppler Lidar Observation and Coupled Mesoscale‐to‐LES Modeling
Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen
優れたB型肝炎予防ワクチン開発に成功 --既存ワクチンの弱点克服へ--. 京都大学プレスリリース. 2022-09-07.Although the current hepatitis B (HB) vaccine comprising small-HBs antigen (Ag) is potent and safe, attenuated prophylaxis against hepatitis B virus (HBV) with vaccine-escape mutations (VEMs) has been reported. We investigate an HB vaccine consisting of large-HBsAg that overcomes the shortcomings of the current HB vaccine. Yeast-derived large-HBsAg is immunized into rhesus macaques, and the neutralizing activities of the induced antibodies are compared with those of the current HB vaccine. Although the antibodies induced by the current HB vaccine cannot prevent HBV infection with VEMs, the large-HBsAg vaccine-induced antibodies neutralize those infections. The HBV genotypes that exhibited attenuated neutralization via these vaccines are different. Here, we show that the HB vaccine consisting of large-HBsAg is useful to compensate for the shortcomings of the current HB vaccine. The combined use of these HB vaccines may induce antibodies that can neutralize HBV strains with VEMs or multiple HBV genotypes
Corrigendum to “An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients”
SYMPLECTIC スウチ カイホウ ニヨル サンイツケイ オヨビ フキソク キドウ ノ アンテイセイ ノ ヒョウカ
It is known that the symplectic method does not give rise to the truncation error. Then, we apply to the dissipative and complicated system, and verify the flexibility of the algorithm. As a result, our demonstration indicates that the symplectic type is more stable
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