Determinants of elementary student's writing tool manipulation skills

Writing, as a skill of correct graphic design, represents an activity which is very important in each individual's life and work, and the period of elementary school, when writing skills are masteres, is the period when special attention must be devoted to determinants that can affect the process of writing. Gender, literacy phase and writing difficulties are the determinants that have been tested in 1156 elementary school students, and the research was done in the eight Belgrade elementary schools in 2016. Statistically significant differences in the writing tools and materials manipulation skills among students with and without writing difficulties were present. The students without writing difficulties had higher manipulation skills, and the biggest difference was recorded in the effective stabilization of paper with the non-dominant hand (r= .000), placing paper under an adequate angle (r= .000) and presenting comments and complaints of pain or fatigue (r= .000). The strongest statistically significant difference with the presence of difficulties in the writing tools and materials manipulation skills between boys and girls is recorded in the effective stabilization of paper with the non-dominant hand (r= .000). Students who are in the process of acquiring literacy skills have the greatest difficulties in the presence of pain or fatigue during writing (23.2% of students). The strongest statistically significant difference in the manipulating skills between students of the first and second grades, compared to the students who have already mastered writing, is in setting up paper at an adequate angle (r= .000) and in the presence of pain or fatigue (r= .000). Gender, the stage of literacy and writing difficulties are determinants that affect the skill of manipulating writing tools. Thus, studying this problem is very important in order to help students master the skills of writing. Individualization measures, as one of the modes of adapting teaching to the abilities of students, can make this complex process significantly easier for them

A family of simultaneous zero-finding methods

AbstractApplying Hansen-Patrick's formula for solving the single equation f(z) = 0 to a suitable function appearing in the classical Weierstrass' method, two one-parameter families of interation functions for the simultaneous approximation of all simple and multiple zeros of a polynomial are derived. It is shown that all the methods of these families have fourth-order of convergence. Some computational aspects of the proposed methods and numerical examples are given

Homeostatic Modulation of Stimulation-Dependent Plasticity in Human Motor Cortex

Since recently, it is possible, using noninvasive cortical stimulation, such as the protocol of paired associative stimulation (PAS), to induce the plastic changes in the motor cortex, in humans that mimic Hebb's model of learning. Application of TMS conjugated with peripheral electrical stimulation at strictly coherent temporal manner lead to convergence of inputs in the sensory-motor cortex, with the consequent synaptic potentiation or weakening, if applied repetitively. However, when optimal interstimulus interval (ISI) for induction of LTP-like effects is applied as a single pair, Motor evoked potential (MEP) amplitude inhibition is observed, the paradigm known as short-latency afferent inhibition (SLAI). Aiming to resolve this paradox, PAS protocols were applied, with 200 repetitions of TMS pulses paired with median nerve electrical stimulation, at ISI equal to individual latencies of evoked response of somatosensory cortex (N-20) (PASLTP), and at ISI of N-20 shortened for 5 msec (PASLTD) protocols that mimic LTP-like changes in the human motor cortex. MEP amplitudes before, during and after interventions were measured as an indicator based on output signals originating from the motor system. Post-intervention MEP amplitudes following the TMS protocols of PASLTP and PASLTD were facilitated and depressed, respectively, contrary to MEP amplitudes during intervention. During PASLTP MEP amplitudes were significantly decreased in case of PASLTP, while in the case of PASLTD an upward trend was observed. In conclusions, a possible explanation for the seemingly paradoxical effect of PAS can be found in the mechanism of homeostatic modulation of plasticity. Those findings indicate the existence of complex relationships in the development of plasticity induced by stimulation, depending on the level of the previous motor cortex excitability

Balance of liquid-phase turbulence kinetic energy equation for bubble-train flow

In this paper the investigation of bubble-induced turbulence using direct numerical simulation (DNS) of bubbly two-phase flow is reported. DNS computations are performed for a bubble-driven liquid motion induced by a regular train of ellipsoidal bubbles rising through an initially stagnant liquid within a plane vertical channel. DNS data are used to evaluate balance terms in the balance equation for the liquid phase turbulence kinetic energy. The evaluation comprises single-phase-like terms (diffusion, dissipation and production) as well Lis the interfacial term. Special emphasis is placed on the procedure for evaluation of interfacial quantities. Quantitative analysis of the balance equation for the liquid phase turbulence kinetic energy shows the importance of the interfacial term which is the only source term. The DNS results are further used to validate closure assumptions employed in modelling of the liquid phase turbulence kinetic energy transport in gas-liquid bubbly flows. In this context, the performance of respective Closure relations in the transport equation for liquid turbulence kinetic energy within the two-phase k-epsilon and the two-phase k-l model is CV evaluated

Revealing the nature of central emission nebulae in the dwarf galaxy NGC 185

In this paper we present new optical observations of the galaxy NGC 185 intended to reveal the status of supernova remnants (SNRs) in this dwarf companion of the Andromeda galaxy. Previously, it was reported that this galaxy hosts one SNR. Our deep photometric study with the 2m telescope at Rozhen National Astronomical Observatory using narrow-band H$\alpha$ and [SII] filters revealed complex structure of the interstellar medium in the center of the galaxy. To confirm the classification and to study the kinematics of the detected nebulae, we carried out spectroscopic observations using the SCORPIO multi-mode spectrograph at the 6m telescope at the Special Astrophysical Observatory of the Russian Academy of Science, both in low- and high-resolution modes. We also searched the archival X-ray and radio data for counterparts of the candidate SNRs identified by our optical observations. Our observations imply the presence of one more SNR, one possible HII region previously cataloged as part of an SNR, and the presence of an additional source of shock ionization in one low-brightness PN. We detected enhanced [SII]/H_alpha and [NII]/H_alpha line ratios, as well as relatively high (up to 90 km s$^{-1}$) expansion velocities of the two observed nebulae, motivating their classification as SNRs (with diameters of 45 pc and 50 pc), confirmed by both photometric and spectral observations. The estimated electron density of emission nebulae is 30 - 200 cm$^{-3}$. Archival XMM-Newton observations indicate the presence of an extended, low-brightness, soft source in projection of one of the optical SNRs, whereas the archival VLA radio image shows weak, unresolved emission in the center of NGC 185.Comment: 15 pages, 14 figures, accepted for publication in A&

Balance of liquid-phase turbulence kinetic energy equation for bubble-train flow

In this paper the investigation of bubble-induced turbulence using direct numerical simulation (DNS) of bubbly two-phase flow is reported. DNS computations are performed for a bubble-driven liquid motion induced by a regular train of ellipsoidal bubbles rising through an initially stagnant liquid within a plane vertical channel. DNS data are used to evaluate balance terms in the balance equation for the liquid phase turbulence kinetic energy. The evaluation comprises single-phase-like terms (diffusion, dissipation and production) as well Lis the interfacial term. Special emphasis is placed on the procedure for evaluation of interfacial quantities. Quantitative analysis of the balance equation for the liquid phase turbulence kinetic energy shows the importance of the interfacial term which is the only source term. The DNS results are further used to validate closure assumptions employed in modelling of the liquid phase turbulence kinetic energy transport in gas-liquid bubbly flows. In this context, the performance of respective Closure relations in the transport equation for liquid turbulence kinetic energy within the two-phase k-epsilon and the two-phase k-l model is CV evaluated

CISPLATIN - AN OVERVIEW OF ITS EFFICIENCY AND TOXICITY

Cisplatin is the first heavy metal compound that has been found to possess antineoplastic activity. It is effective in treating testicular, ovarian, head and neck, bladder, cervical, esophageal tumors, and small cell lung carcinoma. Approximately 1% of cisplatin that enters the cell interacts with DNA, forming DNA-cisplatin bonds. Both apoptosis and necrosis can be found in the same population of cells exposed to cisplatin, and the mode of cell death depends on the cisplatin concentration and metabolic state of the target cell. In the bloodstream, the platinum component of cisplatin binds to the blood's proteins (hemoglobin, albumin and transferrin), and other significant portion binds to the glutathione and other cysteine-rich biomolecules. Cisplatin impairs the mitochondrial and cell antioxidant defense system (decreases GSH, NADPH levels, GCH/GSSG ratio, and increases GSSG levels) leading to oxidative stress. There are three main mechanisms of cell resistance to cisplatin: (1) enhanced repair of cisplatin-induced DNA lesions, (2) decrease in uptake and/or increase in efflux and (3) inactivation of cisplatin intracellularly. The usage of cisplatin is limited due to its toxicity and side effects, which include neurotoxicity (numbness and tingling, paresthesia, reduced deep tendon reflexes), nephrotoxicity (renal insufficiency, hypomagnesemia), ototoxicity (tinnitus and bilateral high-frequency hearing loss), cardiotoxicity (changes in electric heart activity, congestive heart failure), gastrotoxicity (nausea, vomiting, and dyspepsia), etc.  So far, there  has been no effective, clinically administered, therapy for cisplatin-induced toxicity

Boiling heat transfer modelling a review and future prospectus

This paper reviews the current status of boiling heat transfer modelling, discusses the need for its improvement due to unresolved intriguing experimental findings and emergence of novel technical applications and outlines the directions for an advanced modelling approach. The state-of-the-art of computational boiling heat transfer studies is given for: macro-scale boiling models applied in two-fluid liquid-vapour interpenetrating media approach, micro-, meso-scale boiling computations by interface capturing methods, and nano-scale boiling simulations by molecular dynamics tools. Advantages, limitations and shortcomings of each approach, which originate from its grounding formulations, are discussed and illustrated on results obtained by the boiling model developed in our research group. Based on these issues, we stress the importance of adaptation of a multi-scale approach for development of an advanced boiling predictive methodology. A general road-map is outlined for achieving this challenging goal, which should include: improvement of existing methods for computation of boiling on different scales and development of conceptually new algorithms for linking of individual scale methods. As dramatically different time steps of integration for different boiling scales hinder the application of full multi-scale methodology on boiling problems of practical significance, we emphasise the importance of development of another algorithm for the determination of sub-domains within a macro-scale boiling region, which are relevant for conductance of small-scale simulations

Boiling heat transfer modelling a review and future prospectus

This paper reviews the current status of boiling heat transfer modelling, discusses the need for its improvement due to unresolved intriguing experimental findings and emergence of novel technical applications and outlines the directions for an advanced modelling approach. The state-of-the-art of computational boiling heat transfer studies is given for: macro-scale boiling models applied in two-fluid liquid-vapour interpenetrating media approach, micro-, meso-scale boiling computations by interface capturing methods, and nano-scale boiling simulations by molecular dynamics tools. Advantages, limitations and shortcomings of each approach, which originate from its grounding formulations, are discussed and illustrated on results obtained by the boiling model developed in our research group. Based on these issues, we stress the importance of adaptation of a multi-scale approach for development of an advanced boiling predictive methodology. A general road-map is outlined for achieving this challenging goal, which should include: improvement of existing methods for computation of boiling on different scales and development of conceptually new algorithms for linking of individual scale methods. As dramatically different time steps of integration for different boiling scales hinder the application of full multi-scale methodology on boiling problems of practical significance, we emphasise the importance of development of another algorithm for the determination of sub-domains within a macro-scale boiling region, which are relevant for conductance of small-scale simulations