Perception of Communication Network Fraud Dynamics by Network Administrators and Stakeholders

The massive growth of electronic commerce represent a new set of vulnerabilities aimed at the distortion, disruption, and destruction of the global and national information infrastructures, and are indeed significant threats to the integrity of networked systems. This paper investigates the perception of communication network fraud dynamics by network administrators and stakeholders. In considering the implications of the varied nature of the potential targets, the paper identifies the view to develop effective intelligence analysis methodologies for network fraud detection and prevention by network administrators and stakeholders. The paper further notes that organizations are fighting an increasingly complex battle for higher stakeholders, and thus require a greater, enterprise-wide understanding of the threats they face, across all operations and in all territories. In order to establish the appropriateness of the audience, this paper presents an analysis of the interview randomly administered. Informed opinion about the perception index of network administrators and stakeholders is analyzed

MUC1 immunotherapy against a metastatic mammary adenocarcinoma model: Importance of IFN-gamma

Abstract Immunotherapy using mucin 1 (MUC1) linked to oxidised mannan (MFP) was investigated in an aggressive MUC1+ metastatic tumour, DA3-MUC1 because, unlike many MUC1+ tumour models, DA3-MUC1 is not spontaneously rejected in mice making it an alternative model for immunotherapy studies. Further, DA3-MUC1 cells are resistant to lysis by anti-MUC1 cytotoxic T cells (CTLs). The inability of DA3-MUC1 tumours to be rejected in naïve mice as well as vaccination to MUC1 was attributed to a deficiency of expression of MHC class I molecules on the tumour cell surface. In vitro and in vivo analysis of subcutaneous tumours and lung metastases demonstrated that DA3-MUC1 tumour cells have a low expression (&lt; 6%) of MHC class I which can be upregulated (&gt; 90%) following culturing with IFN-γ. Results from flow cytometry analysis and immunoperoxidase staining indicated that the in vitro up-regulation of MHC class I could be maintained for up to seven days in vivo, without affecting the expression levels of MUC1 antigen. Interestingly, MUC1-specific CTL that lyse DA3-MUC1 targets in vitro were induced in MFP immunised mice but failed to protect mice from a DA3-MUC1 tumour challenge. These results highlight the importance of MHC class I molecules in the induction of anti-tumour immunity and the MFP immune response.</jats:p

Selective inhibition of T suppressor-cell function by a monosaccharide

Interactions between regulatory T lymphocytes and other cells are assumed to occur at the level of the cell surface. T cells which suppress the generation of specifically effector cells have been described as having antigenic, idiotypic, allotypic and I-region specificity1−4. Other T suppressor cells generated by in vitro cultivation with or without mitogenic stimulation5,6 have suppressive activity for T and B cells but no specificity can be assigned to them. These T suppressor cells (Ts) inhibit various lymphoid functions—this either reflects their polyclonal origin or indicates that the structures recognized by the Ts receptors must be common for many cell types. Carbohydrates on cell membrane-inserted glycoproteins or glycolipids might function as specific ligands for recognition by cellular receptors or soluble factors. Almost all cell-surface proteins of mammalian cells are glycosylated. There is evidence for lectin-like carbohydrate binding proteins not only in plants7 but also in toxins8, viruses9, prokaryotic cells10 and even mammalian cells, including T cells11. A functional role for these lectin-like proteins has been described for slime moulds and suggested for the selective association of embryonic cells12,13. We report here that addition of a monosaccharide can counteract the effect of T suppressor cells during the generation of alloreactive cytotoxic T cells (CTLs) in vitro

Initial evaluation note : business license simplification, municipality of Lima, Peru

The number of business licenses issued increased by 394%, primarily as a result of the fee reduction, and the simplification and streamlining of the application process. Reforms focused on the municipal procedures to obtain three documents: the certificate of compatibility (zoning), technical clearance (the inspection), and the business license. However, the majority (63%) of survey respondents indicate that “there is no advantage” in obtaining a business license. A more integrated approach that considers reforming the licensing process at the sector and national levels may be necessary

Preliminary crystallographic studies of EcTI, a serine proteinase inhibitor from Enterolobium contortisiliquum seeds

Enterolobium contortisiliquum trypsin inhibitor (EcTI) belongs to the Kunitz family of plant inhibitors, which are widely distributed in nature, especially in plant seeds. EcTI is composed of two polypeptide chains with a total of 174 residues, homologous to other inhibitors from the same family. EcTI crystals, which were obtained with the acupuncture-gel technique, diffract to 2.0 Angstrom resolution and belong to space group P2(1), with unit-cell parameters a = 37.12, b = 38.42, c = 54.08 Angstrom, beta = 98.08 degrees. Molecular-replacement techniques using Erythrina caffra trypsin inhibitor (PDB code 1tie) as the search model indicate one monomer in the asymmetric unit. the secondary-structure content of EcTI was determined by circular dichroism spectroscopy, yielding values compatible with the expected topology.Universidade Federal de São Paulo, EPM, Dept Bioquim, BR-04044020 São Paulo, BrazilUniv São Paulo, IFSC, Lab Cristalog Prot & Biol Mol Estructural, San Carlos, SP, BrazilUniv São Paulo, IFSC, Dept Biofis, San Carlos, SP, BrazilUniversidade Federal de São Paulo, EPM, Dept Bioquim, BR-04044020 São Paulo, BrazilWeb of Scienc

Understanding and Optimising the Social Impact of Venture Capital: Three Lessons from Ghana

Background: Mobilising investment for sustainable development is a priority for many African governments and their international allies. There are many claims about the social impact of investments in small and growing businesses, and yet these mostly focus on good news stories or a narrow set of metrics (jobs created, tax revenue, etc.). There are relatively few studies that consider the diversity of social impacts, particularly in an African context.Objectives: The aim of this research was to work collaboratively with investors in Ghana to better understand social change and contribute to their own work on improved performance and reporting.Method: Using a theory-based examination of social impacts, the research purposively selected a subset of 13 investments from the Venture Capital Trust Fund (VCTF) in Ghana. Theories of change were used to explore the available documentation, triangulated with insights from fund managers, entrepreneurs, senior managers and, where possible, employees. The findings were validated with VCTF staff.Results: While the research demonstrated the usefulness of a theory-based approach, it found it helpful to develop a smaller set of typologies to capture different impact pathways – a more efficient way to assess and report on social returns. In particular, the research highlights how commonly used metrics like job creation undervalue the social impact of some types of investment. Other lessons also included the value of rural businesses (not typically favoured by venture capitalists) and the potential to further extend impacts to lower income groups, but that this required real intent and leadership on the part of investors and entrepreneurs.Conclusion: We conclude that further research is merited on two fronts. Firstly, research into the scale of the small and medium enterprises and the associated investment required to support the operating costs to really manage, improve, monitor and evaluate social impact. And secondly, further field testing of different evaluation techniques to help stakeholders better understand and improve the social benefits of venture capital