Description of \eta-distributions at RHIC energies in terms of a stochastic model

To explain \eta-distributions at RHIC energies we consider the Ornstein-Uhlenbeck process. To account for hadrons produced in the central region, we assume existence of third source located there (y \approx 0) in addition to two sources located at the beam and target rapidities (\pm y_{max} = \pm \ln[\sqrt{s_{NN}}/m_{N}]). This results in better \chi^2/n.d.f. than those for only two sources when analysing data.Comment: 4 pages, 4 figures, PTPTE

On the possibilities of making effective cooperatives in every day life: a constructionist approach

O texto a seguir constitui uma resposta, dentre outras possíveis, para a questão feita por Paul Singer (1998) sobre os motivos que levam uma cooperativa a se degenerar ou não. A metodologia adotada segue os pressupostos construcionistas, que concebem o conhecimento como sendo intersubjetivo e histórico e que, portanto, negam toda essência ou verdade a priori. Assim, ao constatar que existem na historiografia referente ao tema outras noções de cooperativismo, além da organizativa, como as que se referem à questão, denominada por nós, de lugar ou com a questão da doutrina cooperativa, a discussão sobre as possibilidades da efetivação autogestionária de uma cooperativa toma como eixo central a temática do lugar como concebido por Peter Spink (2000): lugar das lutas diárias que agrupamentos realizam para sua sobrevivência.The following text is an answer, among other possible ones, to the question made by Paul Singer (1998) about the reasons that lead or not to the degeneration of a cooperative. The methodology used follows the presuppositions of the constructionists who imagine knowledge as being inter-subjective and historical and that, therefore, deny all essence or truth a priori. Thus, when we verified that there is, in the historiography related to the subject, other notions of cooperativism, beyond of organizational notion, such as the ones that refer to the question, denominated by us the place, or to the question of the cooperative doctrine, the discussion about the possibilities of creating an effective self-managed cooperative takes as its central axis the thematics of the place as conceived by Peter Spink (2000): place of the daily fights that groups go through to survive

Fumarate Hydratase-deficient Renal Cell Carcinoma Successfully Treated with Cabozantinib: A Case Report

Fumarate hydratase-deficient renal cell carcinoma arises from mutations in the fumarate hydratase (FH) gene, representing a rare subset of renal cell carcinoma (RCC). Approximately 19% of patients formerly diagnosed with type 2 papillary RCCs are FH deficient. FH-deficient RCC typically exhibits an aggressive course and is associated with hereditary leiomyomatosis and RCC syndrome in cases with germline mutations. Herein, we report the case involving a 34-year-old Japanese man who experienced a 20-kg weight loss. Computed tomography identified a left renal tumor, leading to a subsequent left nephrectomy. Pathological analysis confirmed FH-deficient RCC. Following diagnosis, the patient underwent treatment with ipilimumab and nivolumab for liver metastasis. Due to disease progression, cabozantinib was administered as second-line therapy, achieving a partial response. Currently, no established standard therapy exists for FH-deficient RCC. Nevertheless, in this case, the multi-kinase inhibitor cabozantinib was effective in combating resistance to immune checkpoint inhibitors.journal articl

Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2‐mutation carriers

The aldehyde degrading function of the ALDH2 enzyme is impaired by Glu504Lys polymorphisms (rs671, termed A allele), which causes alcohol flushing in east Asians, and elevates the risk of esophageal cancer among habitual drinkers. Recent studies suggested that the ALDH2 variant may lead to higher levels of DNA damage caused by endogenously generated aldehydes. This can be a threat to genome stability and/or cell viability in a synthetic manner in DNA repair-defective settings such as Fanconi anemia (FA). FA is an inherited bone marrow failure syndrome caused by defects in any one of so far identified 22 FANC genes including hereditary breast and ovarian cancer (HBOC) genes BRCA1 and BRCA2. We have previously reported that the progression of FA phenotypes is accelerated with the ALDH2 rs671 genotype. Individuals with HBOC are heterozygously mutated in either BRCA1 or BRCA2, and the cancer-initiating cells in these patients usually undergo loss of the wild-type BRCA1/2 allele, leading to homologous recombination defects. Therefore, we hypothesized that the ALDH2 genotypes may impact breast cancer development in BRCA1/2 mutant carriers. We genotyped ALDH2 in 103 HBOC patients recruited from multiple cancer centers in Japan. However, we were not able to detect any significant differences in clinical stages, histopathological classification, or age at clinical diagnosis across the ALDH2 genotypes. Unlike the effects in hematopoietic cells of FA, our current data suggest that there is no impact of the loss of ALDH2 function in cancer initiation and development in breast epithelium of HBOC patients

A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis in Heart and Kidney Transplant Recipients in Japan

journal articl