28 research outputs found
Characterization and Changes of Lymphocyte Subsets in BaricitinibâTreated Patients With Rheumatoid Arthritis
Objective
Baricitinib is an orally administered inhibitor of JAK1 and JAK2 that has been shown to be effective in treating rheumatoid arthritis (RA). This study was undertaken to analyze changes in lymphocyte cell subsets during baricitinib treatment and to correlate these changes with clinical outcomes.
Methods
An integrated analysis was conducted by pooling data from 3 completed phase III trials comparing placebo with baricitinib treatment (RAâBEAM, RAâBUILD, and RAâBEACON) and 1 ongoing longâterm extension study (RAâBEYOND) in patients with active RA (n = 2,186).
Results
Baricitinib treatment was associated with an early transient increase in total lymphocyte count at week 4, which returned to baseline by week 12. Transient changes within normal reference ranges in T cells and subsets were observed with baricitinib treatment, up to week 104. B cells and relevant subpopulations increased after 4 weeks of baricitinib treatment, with no further increases noted through 104 weeks of treatment. Natural killer (NK) cells temporarily increased after 4 weeks of baricitinib treatment, before decreasing below baseline levels and then stabilizing over time. With baricitinib treatment, few correlations were observed between changes in lymphocyte subsets and clinical end points, and most correlations were also observed within the placebo group. A modest potential association between low NK cell numbers and treatmentâemergent infections was observed in the baricitinib 4 mg/day treatment group, but not for serious infections or herpes zoster.
Conclusion
Overall, these findings demonstrate that changes in lymphocyte subsets were largely within normal reference ranges across the baricitinib phase III RA clinical program and were not associated with increased risk of serious infections
Access to Land and Food Security: Analysis of âPriority Cropsâ Production in Ogun State, Nigeria
Using Ogun State located in south-western Nigeria, this chapter draws attention to the increase in output
productivity of priority crops in the State from 2003 to 2015 due to the acquisitions of over 47,334 hectares of agricultural land across 28 communities in different Local Government Areas (LGAs). From Ogun State Agriculture Data, eight priority crops are analyzed: cassava, maize, rice, melon, yam, cocoyam, potato and cowpea. Statistics reveal that the cultivation of cassava gives the highest average output of 4,515,620 metric tonnes and yield per hectare of 16.41 relative to other produce which affirms that Ogun State has the most comparative advantage in the cultivation of cassava followed by maize. The chapter further explores other pro-poor programmes directed at ensuring food security in the State
Epigenetic regulation of caloric restriction in aging
The molecular mechanisms of aging are the subject of much research and have facilitated potential interventions to delay aging and aging-related degenerative diseases in humans. The aging process is frequently affected by environmental factors, and caloric restriction is by far the most effective and established environmental manipulation for extending lifespan in various animal models. However, the precise mechanisms by which caloric restriction affects lifespan are still not clear. Epigenetic mechanisms have recently been recognized as major contributors to nutrition-related longevity and aging control. Two primary epigenetic codes, DNA methylation and histone modification, are believed to dynamically influence chromatin structure, resulting in expression changes of relevant genes. In this review, we assess the current advances in epigenetic regulation in response to caloric restriction and how this affects cellular senescence, aging and potential extension of a healthy lifespan in humans. Enhanced understanding of the important role of epigenetics in the control of the aging process through caloric restriction may lead to clinical advances in the prevention and therapy of human aging-associated diseases
Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer
Heart rate control is associated with reduced cardiovascular events in Asian patients with coronary artery disease treated with bisoprolol (BISO-CAD): results from a multi-national, real-world experience
Measurement of physical activity in the pre- and early post-operative period after total knee arthroplasty for Osteoarthritis using a Fitbit Flex device
Evaluation of galectinâ3, peptidylarginine deiminaseâ4 and tumor necrosis factorâÎą levels in gingival crevicular fluid for periodontal health, gingivitis and stage III grade C periodontitis: A pilot study
Background Comparing the gingival crevicular fluid (GCF) levels of galectin-3, peptidylarginine deiminase 4 (PAD4) and tumor necrosis factor-alpha (TNF-alpha) in individuals with stage III grade C periodontitis and gingivitis and with healthy periodontium was the purpose of this clinical research