40 research outputs found

    The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma

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    The Role of Canine Distemper Virus and Persistent Organic Pollutants in Mortality Patterns of Caspian Seals (Pusa caspica)

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    Persistent organic pollutants are a concern for species occupying high trophic levels since they can cause immunosuppression and impair reproduction. Mass mortalities due to canine distemper virus (CDV) occurred in Caspian seals (Pusa caspica), in spring of 1997, 2000 and 2001, but the potential role of organochlorine exposure in these epizootics remains undetermined. Here we integrate Caspian seal mortality data spanning 1971-2008, with data on age, body condition, pathology and blubber organochlorine concentration for carcases stranded between 1997 and 2002. We test the hypothesis that summed PCB and DDT concentrations contributed to CDV associated mortality during epizootics. We show that age is the primary factor explaining variation in blubber organochlorine concentrations, and that organochlorine burden, age, sex, and body condition do not account for CDV infection status (positive/negative) of animals dying in epizootics. Most animals (57%, n = 67) had PCB concentrations below proposed thresholds for toxic effects in marine mammals (17 μg/g lipid weight), and only 3 of 67 animals had predicted TEQ values exceeding levels seen to be associated with immune suppression in harbour seals (200 pg/g lipid weight). Mean organonchlorine levels were higher in CDV-negative animals indicating that organochlorines did not contribute significantly to CDV mortality in epizootics. Mortality monitoring in Azerbaijan 1971-2008 revealed bi-annual stranding peaks in late spring, following the annual moult and during autumn migrations northwards. Mortality peaks comparable to epizootic years were also recorded in the 1970s-1980s, consistent with previous undocumented CDV outbreaks. Gompertz growth curves show that Caspian seals achieve an asymptotic standard body length of 126-129 cm (n = 111). Males may continue to grow slowly throughout life. Mortality during epizootics may exceed the potential biological removal level (PBR) for the population, but the low frequency of epizootics suggest they are of secondary importance compared to anthropogenic sources of mortality such as fishing by-catch

    Structural phase transition in TbFe2.5Ga0.5(BO3)4 single crystal

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    Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.The Raman spectra of the TbFe2.5Ga0.5(BO3)4 single crystal in the temperature range from 8 to 400 K have been observed. The condensation and restoration of the soft modes have been found. The soft modes are associated with the structural phase transition from the R32 phase to the P3(1)21 phase. The behavior of the hard modes confirms the structural phase transition close to the tricritical point. The temperature of the structural phase transition T(1) = 33 K is established

    Modelling of ground-borne vibration when the train speed approaches the critical speed

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    When trains run on soft ground, large deflections of the track and vibration of the ground can occur when the train speed approaches the speed of Rayleigh waves in the ground. Modelling is helpful to understand and mitigate such critical velocity effects. Here, a three-dimensional time-domain model of a load moving on a track and ground has been developed with the finite element software ABAQUS. This allows nonlinear soil properties to be considered. In order to validate the approach, the vibration of the track and ground induced by a high speed train is compared with those from the site measurements carried out in the late 1990s at Ledsgård, Sweden. Due to the particularly soft soil at this site, it is necessary to adopt a nonlinear soil model due to the large deflections induced by the high-speed train. It is shown that using a linear model based on the small strain soil parameters leads to results which underestimate the displacements. Laboratory test data allow the nonlinear characteristics to be obtained. These have previously been used by various authors in an equivalent linear model. Here this approach is compared with a fully nonlinear model
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