Psychological characteristics of patients with functional and inflammatory bowel disorders

Objective: to study the psychological characteristics of patients with irritable bowel syndrome (IBS), ulcerative colitis (UC), Crohn's disease (CD). Material and methods. The study group included 98 patients with IBD (inflammatory bowel disease) and IBS, the control group included 30 healthy individuals. Set of psychological tests included questionnaire (multifactorial systemic examination of the person), the Luscher color test, Beck Depression Inventory, a test on health, activity, mood. Results. Premorbid personality traits, communication disorders with stress have been revieled. According to the nosology different types of emotional response to the disease, changes in health and activity have been marked. There is a high level of frustration needs, increased frequency of anxiety and depression in all patients. Conclusion. Psychological mechanisms of pathology are similar in functional and organic bowel diseases with the greatest influence on the course of functional disorders

Влияние обструкции верхних дыхательных путей на микроциркуляцию кожи у больных бронхиальной астмой

Background: Pulmonary hemodynamic disorders depend on the inflammatory phases and severity of the obstructive syndrome. However, the effect of asthma bronchial obstruction on the state of peripheral hemodynamics remains insufficiently known. Aims: To study the effects of airway obstruction on skin blood flow parameters and its regulatory systems in patients with persistent atopic bronchial asthma in the remission state.Materials and methods: A comparative study of the skin peripheral blood flow in patients with bronchial asthma with severe airway obstruction (1st group) and without obstruction (2nd group) was conducted. 20 patients with confirmed diagnosis of atopic asthma of 50–74 years old participated in the study. All patients received basic therapy in a constant dosing of high doses of inhaled glucocorticosteroids/long-acting beta-2-agonists. The control group included 20 healthy volunteers without evidence of bronchial obstruction. The study lasted for 3 months. The forced expiratory volume in 1 s (FEV1) was used to evaluate the bronchial obstruction by spirometry technique. Skin blood perfusion changes were recorded by laser Doppler flowmetry at rest and in response to short-term local ischemia. Registered peripheral blood flow signals were examined using the amplitude temporal filtering in five frequency intervals to identify the functional features of the peripheral blood flow regulation systems. Results: Consistent two-fold decrease of the oscillation amplitudes was found in the neurogenic interval at rest (p=0.031), as well as in the myogenic (p=0.043; p=0.031) and endothelial intervals (p=0.037; p≤0.001) both at rest and during the postocclusive reactive hyperemia respectively in the 1st group of patients with bronchial obstruction (FEV1 80%) compared with the control group. No significant changes were revealed for skin blood flow parameters in the 2nd patient group (without obstruction, FEV1 80%) in comparison to control subjects.Conclusions: The presence of bronchial obstruction has a significant impact on the changes of the amplitudes of skin blood flow oscillations in patients with bronchial asthma in the myogenic, neurogenic and endothelial intervals.Обоснование. В настоящее время установлено, что расстройства легочной гемодинамики зависят от фазы воспалительного процесса и выраженности обструктивного синдрома. Однако влияние характерной для бронхиальной астмы обструкции бронхов на состояние периферической гемодинамики остается малоизученным. Цель исследования: изучение влияния обструкции дыхательных путей на параметры кожного кровотока и системы его регуляции у больных с атопической персистирующей бронхиальной астмой в состоянии ремиссии. Методы. Проведено сравнительное исследование параметров кожного периферического кровотока у больных бронхиальной астмой с обструкцией (50% ОФВ1 80%; 1-я группа) и без обструкции (ОФВ1 80%; 2-я группа) дыхательных путей. В исследовании участвовало 20 пациентов с верифицированным диагнозом атопической бронхиальной астмы в возрасте 50−74 лет. Все пациенты получали базисную терапию в режиме постоянного дозирования высоких доз ингаляционных глюкокортикостероидов / длительно действующих бета2-агонистов. В контрольную группу вошли 20 условно здоровых добровольцев без признаков бронхиальной обструкции. Продолжительность исследования составила 3 мес. Бронхиальную обструкцию оценивали по объему форсированного выдоха за первую секунду (ОФВ1) при помощи метода спирометрии. Перфузию кожи кровью регистрировали методом лазерной допплеровской флоуметрии в покое и в ответ на кратковременную локальную ишемию. Для выявления особенностей функционирования систем регуляции кожной микрогемодинамики проводили амплитудно-временную фильтрацию зарегистрированных сигналов периферического кровотока в 5 частотных диапазонах. Результаты. У больных 1-й группы обнаружено достоверное двукратное уменьшение амплитуды колебаний кровотока в частотном диапазоне нейрогенной активности в покое (p=0,031), а также достоверное двукратное снижение амплитуды колебаний кровотока в частотных диапазонах миогенной (p=0,043; p=0,031) и эндотелиальной активности (p=0,037; p≤0,001) в покое и при постокклюзионной реактивной гиперемии, соответственно, по сравнению с контролем. У больных 2-й группы не выявлено достоверных изменений исследуемых параметров кожного кровотока относительно здоровых добровольцев. Заключение. Наличие бронхиальной обструкции оказывает значительное влияние на изменения амплитуд колебаний кровотока в микрососудистом русле кожи больных бронхиальной астмой в частотных диапазонах миогенной, нейрогенной и эндотелиальной активности.

Peculiarities of territorial distribution and dynamics in rates of population noncommunicable diseases in the Krasnoyarsk Region associated with the influence of environmental risk factors

The analysis of the primary morbidity dynamics in the population of the Krasnoyarsk region is performed for the period 2005–2015. The incidence forecast by classes of ICD diseases, X revision is calculated. It was found that the figures of the first time revealed incidence in the Krasnoyarsk region exceeded the average for the Russian Federation during the years 2011–2014 on neoplasms, nervous system diseases, diseases of the circulatory and the digestive systems, diseases of the musculoskeletal system and connective tissue, endocrine diseases and a number of other systems. The values of the integral health risk indicators are calculated by the methodology of State Sanitary and Epidemiological Surveillance Agency of the year 1995. For risk characteristics the following criteria are used: integral index of health less than <0.312 – minimal risk; 0.313–0.500 – moderate risk; 0.501–0.688 – increased risk of more than 0.689 – the highest risk. It was found that the increased health risk is typical of 21 municipal territories of the region, which is home to 66.1 % of the population. Among the areas with “high” public health risk in different years were Sharypovo, Birilyussy and Evenk districts. In most areas the priorities relate to a group of non-communicable diseases associated with the negative impact of various factors of habitat population (disease of the respiratory system, circulatory system, neoplasms, including malignant, etc.). According to the forecasts in 2016 we expect the decrease in the proportion of inhabitants in the region from the group with the “moderate” and “elevated” risk, and an increase in the number of people with “high” and “minimal” risk to public health. It is shown that a number of regional municipalities have a necessity in the planning and implementation of measures to improve the population health

Hygienic assessment of ambient air quality and health risks to population of Krasnoyarsk region

This study fulfills the hygienic assessment of ambient air quality in the populated areas of the Krasnoyarsk Region. It is shown that the total number of emission sources in the region is more than 23 600 units, what is higher than in previous years. Around 90.7 % out of them correspond to the set standards of permissible emissions. Air monitoring was carried by the establishments of Roshydromet, Rospotrebnadzor and by other organizations at 94 observation posts in eight urban districts and 2 municipal districts of the region. The status of the ambient air in a sequence of the populated areas of Krasnoyarsk region, namely in the cities Achinsk, Kansk, Krasnoyarsk, Lesosibirsk, Minusinsk, Norilsk, is characterized by the presence of certain pollutants, the level of which exceeds the hygienic standards. Prioritized pollutants are benzo(a)pyrene, suspended solids, nitrogen, and sulfur dioxide, formaldehyde and others. In the settlements the economic entities violate the legal requirements in the field of sanitary and epidemiological welfare of the population. The probability of the population’s health deterioration grows along with the growth of risk factors. The risks of respiratory diseases, immune system, blood and blood-forming organs and the additional mortality are assessed as unacceptable. Ensuring air quality of the urban residential areas and municipal districts of the Krasnoyarsk Territory requires the introducing the complex measures to improve it. The established levels of human health risk associated with exposure to polluted air are an additional criterion for selection of the priority objects when planning the implementation of risk-based model for supervisory activities in the field of sanitary and epidemiological welfare of the population

Peculiarities of territorial distribution and dynamics in rates of population noncommunicable diseases in the Krasnoyarsk Region associated with the influence of environmental risk factors

The analysis of the primary morbidity dynamics in the population of the Krasnoyarsk region is performed for the period 2005–2015. The incidence forecast by classes of ICD diseases, X revision is calculated. It was found that the figures of the first time revealed incidence in the Krasnoyarsk region exceeded the average for the Russian Federation during the years 2011–2014 on neoplasms, nervous system diseases, diseases of the circulatory and the digestive systems, diseases of the musculoskeletal system and connective tissue, endocrine diseases and a number of other systems. The values of the integral health risk indicators are calculated by the methodology of State Sanitary and Epidemiological Surveillance Agency of the year 1995. For risk characteristics the following criteria are used: integral index of health less than <0.312 – minimal risk; 0.313–0.500 – moderate risk; 0.501–0.688 – increased risk of more than 0.689 – the highest risk. It was found that the increased health risk is typical of 21 municipal territories of the region, which is home to 66.1 % of the population. Among the areas with “high” public health risk in different years were Sharypovo, Birilyussy and Evenk districts. In most areas the priorities relate to a group of non-communicable diseases associated with the negative impact of various factors of habitat population (disease of the respiratory system, circulatory system, neoplasms, including malignant, etc.). According to the forecasts in 2016 we expect the decrease in the proportion of inhabitants in the region from the group with the “moderate” and “elevated” risk, and an increase in the number of people with “high” and “minimal” risk to public health. It is shown that a number of regional municipalities have a necessity in the planning and implementation of measures to improve the population health

Factor analysis of hemodynamics daily parameters in students of the Northern Medical University

The purpose was to find out the hidden common factors characterizing the relationship between the parameters of daily hemodynamics in students of the northern medical university. Methods. A factor analysis of hemodynamics data obtained during the daily monitoring of arterial pressure and heart rate in students of Khanty-Mansiysk State Medical Academy (35 boys and 61 girls) was carried out. Results. The analysis revealed two factors in groups. According to the first factor, the mesor factor loading of the index of functional changes (r = 0,833) and the daytime values of the IFI (r = 0,923) and the IAD DB (r = 0,708) achieved significant values in the young men. In the girls: SAD (r = 0,862), DBP (r = 0,767) and IFI (r = 0,919), daily SBP values (r = 0,889), DBP (r = 0,867), IFI (r = 0,942), IV DBP (r = 0,713) (total dispersions are 34,37 % and 39,05 %). The second factor included night hemodynamic parameters in both groups. The young men had: IFI night (r = 0,808), SAD night. (r = 0,813), DBP overnight. (r = 0,892), IV SBP overnight. (r = 0,766), IV DBP at night. (r = 0,778), night decrease of SBP (r = –0,822) and DBP (r = –0,806), in girls: SAD night. (r = 0,776), DBP overnight. (r = 0,836), IV DBP of night. (r = 0,740), SB SBP (r = –0,797) and NS DBP (r = –0,865) (the total variance is 23,04 % and 17,68 %). Conclusion. Differences were found in the structure of the relationship of hemodynamic indices associated with gender. The first factor was formed by daily and average daily hemodynamic indices; in girls its composition is determined by a large number of variables 7 against 3 in boys. The second factor was formed by the night values of hemodynamic indices in both groups. Day and night indices of hemodynamics did not correlate. © 2018 Northern State Medical University. All Rights Reserved

EFFECTIVENESS OF FORMULA BASED ON CASEIN HYDROLYSATE IN CHILDREN WITH ALLERGY TO PROTEINS OF COW’S MILK

Dietotherapy along with medicinal and external treatment is one of components of complex treatment of atopic dermatitis (AD) in children. Severe forms of alimentary allergy are treated with special formulas based on casein hydrolisates. Clinical effectiveness of such formula was studied in 20 patients 2–7 months old intolerant to proteins of cow’s and goat’s milk. Treatment resulted in remission achievement, lessening of external therapy and cancellation of medicinal one in all children including those with cutaneous and gastrointestinal symptoms of AD.Key words: children, atopic dermatitis, dietotherapy, casein hydrolysate, SCORAD.(Voprosy sovremennoi pediatrii — Current Pediatrics. – 2010;9(3):97-101)</p

EFFECTIVENESS OF FORMULA BASED ON CASEIN HYDROLYSATE IN CHILDREN WITH ALLERGY TO PROTEINS OF COW’S MILK

Dietotherapy along with medicinal and external treatment is one of components of complex treatment of atopic dermatitis (AD) in children. Severe forms of alimentary allergy are treated with special formulas based on casein hydrolisates. Clinical effectiveness of such formula was studied in 20 patients 2–7 months old intolerant to proteins of cow’s and goat’s milk. Treatment resulted in remission achievement, lessening of external therapy and cancellation of medicinal one in all children including those with cutaneous and gastrointestinal symptoms of AD.Key words: children, atopic dermatitis, dietotherapy, casein hydrolysate, SCORAD.(Voprosy sovremennoi pediatrii — Current Pediatrics. – 2010;9(3):97-101

Factor analysis of hemodynamics daily parameters in students of the Northern Medical University

The purpose was to find out the hidden common factors characterizing the relationship between the parameters of daily hemodynamics in students of the northern medical university. Methods. A factor analysis of hemodynamics data obtained during the daily monitoring of arterial pressure and heart rate in students of Khanty-Mansiysk State Medical Academy (35 boys and 61 girls) was carried out. Results. The analysis revealed two factors in groups. According to the first factor, the mesor factor loading of the index of functional changes (r = 0,833) and the daytime values of the IFI (r = 0,923) and the IAD DB (r = 0,708) achieved significant values in the young men. In the girls: SAD (r = 0,862), DBP (r = 0,767) and IFI (r = 0,919), daily SBP values (r = 0,889), DBP (r = 0,867), IFI (r = 0,942), IV DBP (r = 0,713) (total dispersions are 34,37 % and 39,05 %). The second factor included night hemodynamic parameters in both groups. The young men had: IFI night (r = 0,808), SAD night. (r = 0,813), DBP overnight. (r = 0,892), IV SBP overnight. (r = 0,766), IV DBP at night. (r = 0,778), night decrease of SBP (r = –0,822) and DBP (r = –0,806), in girls: SAD night. (r = 0,776), DBP overnight. (r = 0,836), IV DBP of night. (r = 0,740), SB SBP (r = –0,797) and NS DBP (r = –0,865) (the total variance is 23,04 % and 17,68 %). Conclusion. Differences were found in the structure of the relationship of hemodynamic indices associated with gender. The first factor was formed by daily and average daily hemodynamic indices; in girls its composition is determined by a large number of variables 7 against 3 in boys. The second factor was formed by the night values of hemodynamic indices in both groups. Day and night indices of hemodynamics did not correlate. © 2018 Northern State Medical University. All Rights Reserved