1,302 research outputs found
ΠΠΠΠΠΠ-Π‘ΠΠ¦ΠΠΠΠ¬ΠΠ«Π ΠΠ ΠΠΠΠΠΠ« ΠΠ‘ΠΠΠΠΠΠΠ’ΠΠΠ¬ΠΠ«Π₯ Π ΠΠΠ ΠΠΠ£ΠΠ’ΠΠΠΠ«Π₯ Π’ΠΠ₯ΠΠΠΠΠΠΠ Π‘ ΠΠΠΠΠ¦ΠΠ ΠΠΠΠΠΠ’Π ΠΠ
The article presents a literature review over the last few years devoted to the health status and development peculiarities of children born using assisted reproductive technologies (ART) procedures. The statistics shows an explosive increase in the frequency of ART application as a fertility treatment method. The presented data analysis reflects the perinatal outcomes after ART in children, the frequency of congenital malformations and genetic diseases in this population, possible long-term malconditions and pathologies in children born using ART. The overwhelming majority of investigators consider the adverse effect of ART on a childβs body to be the result of prematurity and multiple pregnancy (transfer multiple embryos followed by partial reduction). It is stated that the widespread introduction of ART may contribute to the vertical transmission of parental infertility factors in the population. The application of ART procedures in some cases is associated with controversial ethical and legal issues (surrogacy, oocyte donation). Further improvements in ART procedures (preimplantation training, medical and genetic diagnosis, reducing the frequency of multiple pregnancy) cannot be stated as an alternative to the general medical and social prevention of reproductive disorders in adolescents and youth.Β Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π΄Π°Π½Π½ΡΡ
Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
Π»Π΅Ρ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΠΎΠΉ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π·Π΄ΠΎΡΠΎΠ²ΡΡ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π΄Π΅ΡΠ΅ΠΉ, ΡΠΎΠ΄ΠΈΠ²ΡΠΈΡ
ΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π²ΡΠΏΠΎΠΌΠΎΠ³Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ (ΠΠ Π’). ΠΠ°Π½Π½ΡΠ΅ ΡΡΠ°ΡΠΈΡΡΠΈΠΊΠΈ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎ Π»Π°Π²ΠΈΠ½ΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎΠΌ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠΈ ΡΠ°ΡΡΠΎΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΠ Π’ ΠΊΠ°ΠΊ ΠΌΠ΅ΡΠΎΠ΄Π° Π»Π΅ΡΠ΅Π½ΠΈΡ Π±Π΅ΡΠΏΠ»ΠΎΠ΄ΠΈΡ. Π ΠΎΠ±Π·ΠΎΡΠ΅ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΎΡΡΠ°ΠΆΠ΅Π½Ρ ΠΈΡΡ
ΠΎΠ΄Ρ ΠΏΠ΅ΡΠΈΠ½Π°ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΏΠΎΡΠ»Π΅ ΠΠ Π’, ΡΠ°ΡΡΠΎΡΠ° Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ
ΠΏΠΎΡΠΎΠΊΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π² ΡΡΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠ΅ ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΠ΅ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Ρ Π΄Π΅ΡΠ΅ΠΉ, ΡΠΎΠ΄ΠΈΠ²ΡΠΈΡ
ΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΠ Π’. ΠΠΎΠ΄Π°Π²Π»ΡΡΡΠ΅Π΅ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ ΡΠ²ΡΠ·ΡΠ²Π°ΡΡ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΠ Π’ Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΡΠ΅Π±Π΅Π½ΠΊΠ° Ρ Π½Π΅Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΠΎΡΡΡΡ ΠΈ ΠΌΠ½ΠΎΠ³ΠΎΠΏΠ»ΠΎΠ΄ΠΈΠ΅ΠΌ (ΡΡΠ°Π½ΡΡΠ΅Ρ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΡ
ΡΠΌΠ±ΡΠΈΠΎΠ½ΠΎΠ² Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ ΡΠ°ΡΡΠΈΡΠ½ΠΎΠΉ ΡΠ΅Π΄ΡΠΊΡΠΈΠ΅ΠΉ). Π£ΠΊΠ°Π·ΡΠ²Π°Π΅ΡΡΡ, ΡΡΠΎ ΡΠΈΡΠΎΠΊΠΎΠ΅ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΠ΅ ΠΠ Π’ ΠΌΠΎΠΆΠ΅Ρ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ Π²Π΅ΡΡΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠ΅ΡΠ΅Π΄Π°ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΎΠ΄ΠΈΡΠ΅Π»ΡΡΠΊΠΎΠ³ΠΎ Π±Π΅ΡΠΏΠ»ΠΎΠ΄ΠΈΡ Π² ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΠ Π’ Π² Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
ΡΠ»ΡΡΠ°ΡΡ
ΡΠΎΠΏΡΡΠΆΠ΅Π½ΠΎ ΡΠΎ ΡΠΏΠΎΡΠ½ΡΠΌΠΈ ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ ΠΏΡΠ°Π²ΠΎΠ²ΡΠΌΠΈ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌΠΈ (ΡΡΡΡΠΎΠ³Π°ΡΠ½ΠΎΠ΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ½ΡΡΠ²ΠΎ, Π΄ΠΎΠ½ΠΎΡΡΡΠ²ΠΎ ΠΎΠΎΡΠΈΡΠΎΠ²). ΠΠ°Π»ΡΠ½Π΅ΠΉΡΠ΅Π΅ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ ΠΠ Π’ (ΠΏΡΠ΅Π΄ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ°, ΠΌΠ΅Π΄ΠΈΠΊΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ°, ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠ΅ ΡΠ°ΡΡΠΎΡΡ ΠΌΠ½ΠΎΠ³ΠΎΠΏΠ»ΠΎΠ΄ΠΈΠΉ) Π½Π΅ ΡΠ²Π»ΡΠ΅ΡΡΡ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²ΠΎΠΉ Π΄Π»Ρ ΡΠΈΡΠΎΠΊΠΎΠΉ ΠΌΠ΅Π΄ΠΈΠΊΠΎ-ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Π² ΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΡΠ΅ΡΠ΅ Ρ ΠΏΠΎΠ΄ΡΠΎΡΡΠΊΠΎΠ² ΠΈ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠΈ.
Π£ΡΠ°ΡΡΠΈΠ΅ Ρ ΠΎΠ»ΠΈΠ½Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ Π°Π΄ΡΠ΅Π½Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π² ΡΠ΅Π°ΠΊΡΠΈΡΡ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° Π½Π° Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½Π°
This study is dedicated to investigation of serotoninergic structures that activate motility of the stomach. Experiments were performed on 94 Wistar rats under general anesthesia, mechanical ventilation, bilateral vagotomy and transection of both glossopharyngeal nerves. Mechanical activity of the stomach was recorded during serotonin adipanate infusion to intact animals and on the background of the ongoing actions of cholinergic and adrenergic antagonists. The blockade of adrenergic and cholinergic receptors does not prevent, but contrary, increase stimulatory effect of serotonin. Ξ²-adrenergic blockade increases the intensity of observed reactions almost up to 90%. Conclusion: both adrenergic and cholinergic mechanisms provide inhibitory pattern on serotoninergic structures that regulates motor function of the stomach.Π Π°Π±ΠΎΡΠ° ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΡΡΠΊΡΡΡ, ΡΡΠΈΠ»ΠΈΠ²Π°ΡΡΠΈΡ
ΠΌΠΎΡΠΎΡΠΈΠΊΡ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°. ΠΠΏΡΡΡ ΠΏΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ Π½Π° 94 ΠΊΡΡΡΠ°Ρ
Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠ°Π΄ΠΈΠΈ Π½Π°ΡΠΊΠΎΠ·Π°, ΠΠΠ, Π΄Π²ΡΡ
ΡΡΠΎΡΠΎΠ½Π½Π΅ΠΉ Π²Π°Π³ΠΎΡΠΎΠΌΠΈΠΈ ΠΈ Π΄Π²ΡΡ
ΡΡΠΎΡΠΎΠ½Π½Π΅ΠΉ ΠΏΠ΅ΡΠ΅ΡΠ΅Π·ΠΊΠΈ ΡΠ·ΡΠΊΠΎΠ³Π»ΠΎΡΠΎΡΠ½ΡΡ
Π½Π΅ΡΠ²ΠΎΠ². Π Π΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΠΌΠ΅Ρ
Π°Π½ΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° Π½Π° Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½Π° Π°Π΄ΠΈΠΏΠΈΠ½Π°ΡΠ° Ρ ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΈ Π½Π° ΡΠΎΠ½Π΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ°ΡΡΠ΅Π³ΠΎΡΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π°Π΄ΡΠ΅Π½ΠΎ- ΠΈ Ρ
ΠΎΠ»ΠΈΠ½ΠΎΠ±Π»ΠΎΠΊΠ°ΡΠΎΡΠΎΠ². Π£ΡΡΠ°Π½ΠΎΠ²ΠΈΠ»ΠΈ, ΡΡΠΎ Π±Π»ΠΎΠΊΠ°Π΄Π° Π°Π΄ΡΠ΅Π½ΠΎ- ΠΈ Ρ
ΠΎΠ»ΠΈΠ½ΠΎΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ Π½Π΅ ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΡΠ΅Ρ, Π° Π½Π°ΠΏΡΠΎΡΠΈΠ², ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° Π½Π° ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½, ΠΏΡΠΈΡΠ΅ΠΌ Π±Π»ΠΎΠΊΠ°Π΄Π° Ξ²-Π°Π΄ΡΠ΅Π½ΠΎΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π»Π° Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ ΡΡΠΈΠΌΡΠ»ΡΡΠΎΡΠ½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΏΠΎΡΡΠΈ Π½Π° 90%. Π‘Π΄Π΅Π»Π°Π»ΠΈ Π²ΡΠ²ΠΎΠ΄ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ Π°Π΄ΡΠ΅Π½Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ Ρ
ΠΎΠ»ΠΈΠ½Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΡΡΡ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΡΡΠΈΠΌΡΠ»ΡΡΠΎΡΠ½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½ΠΎΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΡΡΡΡΠΊΡΡΡ Π½Π° ΠΌΠΎΡΠΎΡΠΈΠΊΡ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°
On Darboux-Treibich-Verdier potentials
It is shown that the four-parameter family of elliptic functions
introduced
by Darboux and rediscovered a hundred years later by Treibich and Verdier, is
the most general meromorphic family containing infinitely many finite-gap
potentials.Comment: 8 page
The magnetic ordering in the mixed valence compound beta-Na0.33V2O5
The low-temperature electron spin resonance (ESR) spectra and the static
magnetization data obtained for the stoichiometric single crystals of
-NaVO indicate that this quasi-one-dimensional mixed
valence (V4+/V5+) compound demonstrates at K the phase transition into
the canted antiferromagnetically ordered state. The spontaneous magnetization
of per V ion was found to be oriented along
the two-fold axis of the monoclinic structure, the vector of
antiferromagnetism is aligned with the axis and the Dzyaloshinsky vector is
parallel to the -axis. The experimental data were successfully described in
the frame of the macroscopic spin dynamics and the following values for the
macroscopic parameters of the spin system were obtained: the Dzyaloshinsky
field kOe, the energy gaps of two branches of the spin wave spectrum
GHz and GHz.Comment: 5 pages, 6 figure
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ CYP2D6 Π½Π° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ ΡΠ»ΡΠ²ΠΎΠΊΡΠ°ΠΌΠΈΠ½Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠ²Π½ΡΠΌΠΈ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, ΠΊΠΎΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΠΌΠΈ Ρ Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡΡ
Background: Alcohol dependence is often combined with affective disorders, in particular, depressive disorder (DD), which worsens adversely affects the prognosis of the course of both diseases and their outcomes. For the treatment of DD, drugs from the group of selective serotonin reuptake inhibitors, whose representative is fluvoxamine, are used. Fluvoxamine therapy is often associated with a risk of development is shown to be ineffective, and a part of patients develop dose-dependent adverse drug reactions (ADR) and pharmacoresistance.Objective: To study the effects of CYPD6 isoenzyme activity on the efficacy and safety of fluvoxamine therapy in patients with depressive disorders, comorbid with alcoholism.Methods: The study was conducted on 117 Russian patients with DD, alcohol-dependent comorbid. For the purpose of correction of depressive disorders within the framework of cyclothymia, fluvoxamine (Fevarin) was administered to patients at a dosage of 50β150 mg/day. Genotyping was carried out by the method of polymerase chain reaction in Real-time mode with allele-specific hybridization. Efficacy and safety were assessed using validated psychometric scales and an assessment of the severity of ADR. To evaluate the activity of CYP2D6, the method of high performance liquid chromatography with mass spectrometry was used to measure the urinary content of the endogenous substrate of this isoenzyme and its metabolite, the ratio of 6-hydroxy-1,2,3,4-tetrahydro-beta-carboline.Results: By the 9th day of the study, the severity of depressive symptoms on the HAMD scale was statistically significantly different in patients with different genotypes: (GG) 7.0 [6.0; 8.0], (GA) 4.0 [3.0; 5.0] (p0.001); safety indicator, estimated on a UKU scale: 3.0 [2.0; 4.0], (GA) 4.0 [4.0; 4.2] (p0.001). The presence of differences persisted on the 16th day: (GG) 5.0 [3.0; 6.0], (GA) 1.5 [1.0; 3.0] (p0.001); safety indicator, estimated on a UKU scale: (GG) 9.0 [9.0; 10.0], (GA) 6.0 [6.0; 7.0] (p0.001). The calculation of the correlation coefficients between the difference in the number of scores on psychometric scales and the metabolic ratio showed a statistically significant inverse correlation of the average power degree between the efficiency index estimated by the HAMD scale (r=-0.467, p0.05). There was no connection with the difference on the UKU scale (r=0.173, p0.05).Conclusion: In a study of a group of 117 patients with DD, comorbid with alcohol dependence, the effect of CYP2D6 activity, estimated by the ratio of the endogenous substrate concentrations of pinolin and its metabolite 6-hydroxy-1,2,3,4-tetrahydro-beta-carboline, on the efficacy of fluvoxamine therapy. This effect was also shown using the results of genotyping. The results of genotyping also showed the existence of a difference in the safety index in patients with different genotypes from the polymorphic marker CYP2D6 1846GA.ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΠ»ΠΊΠΎΠ³ΠΎΠ»ΡΠ½Π°Ρ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΡΠ°ΡΡΠΎ ΡΠΎΡΠ΅ΡΠ°Π΅ΡΡΡ Ρ Π°ΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠ²Π½ΡΠΌ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ, ΡΡΠΎ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎ ΡΠΊΠ°Π·ΡΠ²Π°Π΅ΡΡΡ Π½Π° ΠΏΡΠΎΠ³Π½ΠΎΠ·Π΅ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΎΠ±ΠΎΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. ΠΠ»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π° ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΠ΅ ΡΡΠ΅Π΄ΡΡΠ²Π° ΠΈΠ· Π³ΡΡΠΏΠΏΡ ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² ΠΎΠ±ΡΠ°ΡΠ½ΠΎΠ³ΠΎ Π·Π°Ρ
Π²Π°ΡΠ° ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½Π°, ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»Π΅ΠΌ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ»ΡΠ²ΠΎΠΊΡΠ°ΠΌΠΈΠ½. Π’Π΅ΡΠ°ΠΏΠΈΡ ΡΠ»ΡΠ²ΠΎΠΊΡΠ°ΠΌΠΈΠ½ΠΎΠΌ ΡΠΎΠΏΡΡΠΆΠ΅Π½Π° Ρ ΡΠΈΡΠΊΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π΅ΠΆΠ΅Π»Π°ΡΠ΅Π»ΡΠ½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ ΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ. Π Π±ΠΎΠ»Π΅Π΅ ΡΠ°Π½Π½ΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° CYP2D6, ΠΊΠΎΠ΄ΠΈΡΡΡΡΠ΅Π³ΠΎ ΠΎΠ΄Π½ΠΎΠΈΠΌΠ΅Π½Π½ΡΠΉ ΠΈΠ·ΠΎΡΠ΅ΡΠΌΠ΅Π½Ρ, Π½Π° ΡΠ°ΡΡΠΎΡΡ ΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ Π½Π΅ΠΆΠ΅Π»Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ ΡΠ»ΡΠ²ΠΎΠΊΡΠ°ΠΌΠΈΠ½Π°.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΈΠ·ΡΡΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈΠ·ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ° CYPD6 Π½Π° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ»ΡΠ²ΠΎΠΊΡΠ°ΠΌΠΈΠ½ΠΎΠΌ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠ²Π½ΡΠΌΠΈ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, ΠΊΠΎΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΠΌΠΈ Ρ Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΠΈΠ·ΠΌΠΎΠΌ.ΠΠ΅ΡΠΎΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π½Π° 117 ΡΡΡΡΠΊΠΈΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°Ρ
Ρ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠ²Π½ΡΠΌΠΈ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, ΠΊΠΎΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΠΌΠΈ Ρ Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡΡ. ΠΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ Ρ ΡΠ΅Π»ΡΡ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠ²Π½ΡΡ
ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ² Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΡΠΈΠΊΠ»ΠΎΡΠΈΠΌΠΈΠΈ Π±ΡΠ» Π½Π°Π·Π½Π°ΡΠ΅Π½ ΡΠ»ΡΠ²ΠΎΠΊΡΠ°ΠΌΠΈΠ½ Π² Π΄ΠΎΠ·ΠΈΡΠΎΠ²ΠΊΠ΅ 50β150 ΠΌΠ³/ΡΡΡ. ΠΠ΅Π½ΠΎΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ CYP2D6*4 (1846GA, rs3892097) ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΎΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ Π² ΡΠ΅ΠΆΠΈΠΌΠ΅ ΡΠ΅Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ Ρ Π°Π»Π»Π΅Π»ΡΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π³ΠΈΠ±ΡΠΈΠ΄ΠΈΠ·Π°ΡΠΈΠ΅ΠΉ. ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π²Π°Π»ΠΈΠ΄ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΡΠΈΡ
ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΊΠ°Π» ΠΈ ΡΠΊΠ°Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ Π½Π΅ΠΆΠ΅Π»Π°ΡΠ΅Π»ΡΠ½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ. ΠΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ CYP2D6 ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ Π²ΡΡΠΎΠΊΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ½ΠΎΠΉ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ Ρ ΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΈΠ΅ΠΉ ΠΏΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π² ΠΌΠΎΡΠ΅ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠ±ΡΡΡΠ°ΡΠ° Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΠ·ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ° ΠΈ Π΅Π³ΠΎ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ° β ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ 6-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-1,2,3,4-ΡΠ΅ΡΡΠ°Π³ΠΈΠ΄ΡΠΎ-Π±Π΅ΡΠ°-ΠΊΠ°ΡΠ±ΠΎΠ»ΠΈΠ½Π°.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π 9-ΠΌΡ Π΄Π½Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠΉ ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΡΠΈΠΊΠΈ ΠΏΠΎ ΡΠΊΠ°Π»Π΅ HAMD ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎ ΠΎΡΠ»ΠΈΡΠ°Π»Π°ΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ°Π·Π½ΡΠΌΠΈ Π³Π΅Π½ΠΎΡΠΈΠΏΠ°ΠΌΠΈ: (GG) 7,0 [6,0; 8,0], (GA) 4,0 [3,0; 5,0] (p0,001); ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ, ΠΎΡΠ΅Π½Π΅Π½Π½ΡΠΉ ΠΏΠΎ ΡΠΊΠ°Π»Π΅ UKU: 3,0 [2,0; 4,0], (GA) 4,0 [4,0; 4,2] (p0,001). ΠΠ°Π»ΠΈΡΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΠΉ ΡΠΎΡ
ΡΠ°Π½ΡΠ»ΠΎΡΡ ΠΈ Π½Π° 16-ΠΉ Π΄Π΅Π½Ρ: (GG) 5,0 [3,0; 6,0], (GA) 1,5 [1,0; 3,0] (p0,001); ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ, ΠΎΡΠ΅Π½Π΅Π½Π½ΡΠΉ ΠΏΠΎ ΡΠΊΠ°Π»Π΅ UKU: (GG) 9,0 [9,0; 10,0], (GA) 6,0 [6,0; 7,0] (p0,001). Π Π°ΡΡΠ΅Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠ² ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ°Π·Π½ΠΈΡΠ΅ΠΉ Π² ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅ Π±Π°Π»Π»ΠΎΠ² ΠΏΠΎ ΠΏΡΠΈΡ
ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΊΠ°Π»Π°ΠΌ ΠΈ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎΠΊΠ°Π·Π°Π» Π½Π°Π»ΠΈΡΠΈΠ΅ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠΉ ΠΎΠ±ΡΠ°ΡΠ½ΠΎΠΉ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΡΡΠ΅Π΄Π½Π΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΠΈΠ»Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΌ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, ΠΎΡΠ΅Π½Π΅Π½Π½ΠΎΠΉ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΊΠ°Π»Ρ HAMD (r=-0,467, p0,05). Π‘Π²ΡΠ·Ρ Ρ ΡΠ°Π·Π½ΠΈΡΠ΅ΠΉ ΠΏΠΎ ΡΠΊΠ°Π»Π΅ UKU ΠΎΡΡΡΡΡΡΠ²ΠΎΠ²Π°Π»Π° (r=0,173, p0,05).ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π Π΄Π°Π½Π½ΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ Π±ΡΠ»ΠΎ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ CYP2D6, ΠΎΡΠ΅Π½Π΅Π½Π½ΠΎΠΉ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠ±ΡΡΡΠ°ΡΠ° ΠΏΠΈΠ½ΠΎΠ»ΠΈΠ½Π° ΠΈ Π΅Π³ΠΎ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ° 6-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-1,2,3,4-ΡΠ΅ΡΡΠ°Π³ΠΈΠ΄ΡΠΎ-Π±Π΅ΡΠ°-ΠΊΠ°ΡΠ±ΠΎΠ»ΠΈΠ½Π°, Π½Π° ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ»ΡΠ²ΠΎΠΊΡΠ°ΠΌΠΈΠ½ΠΎΠΌ. ΠΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ CYP2D6 ΡΠ½ΠΈΠΆΠ°Π΅Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ»ΡΠ²ΠΎΠΊΡΠ°ΠΌΠΈΠ½ΠΎΠΌ. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ CYP2D6 Π½Π° Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΎ Π½Π΅ Π±ΡΠ»ΠΎ. Π’Π΅ΠΌ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° CYP2D6 Π½Π° ΠΏΡΠΎΡΠΈΠ»Ρ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ
Theory of the first-order isostructural valence phase transitions in mixed valence compounds YbIn_{x}Ag_{1-x}Cu_{4}
For describing the first-order isostructural valence phase transition in
mixed valence compounds we develop a new approach based on the lattice Anderson
model. We take into account the Coulomb interaction between localized f and
conduction band electrons and two mechanisms of electron-lattice coupling. One
is related to the volume dependence of the hybridization. The other is related
to local deformations produced by f- shell size fluctuations accompanying
valence fluctuations. The large f -state degeneracy allows us to use the 1/N
expansion method. Within the model we develop a mean-field theory for the
first-order valence phase transition in YbInCu_{4}. It is shown that the
Coulomb interaction enhances the exchange interaction between f and conduction
band electron spins and is the driving force of the phase transition. A
comparison between the theoretical calculations and experimental measurements
of the valence change, susceptibility, specific heat, entropy, elastic
constants and volume change in YbInCu_{4} and YbAgCu_{4} are presented, and a
good quantitative agreement is found. On the basis of the model we describe the
evolution from the first-order valence phase transition to the continuous
transition into the heavy-fermion ground state in the series of compounds
YbIn_{1-x}Ag_{x}Cu_{4}. The effect of pressure on physical properties of
YbInCu_{4} is studied and the H-T phase diagram is found.Comment: 17 pages RevTeX, 9 Postscript figures, to be submitted to Phys.Rev.
Fractal iso-contours of passive scalar in smooth random flows
We consider a passive scalar field under the action of pumping, diffusion and
advection by a smooth flow with a Lagrangian chaos. We present theoretical
arguments showing that scalar statistics is not conformal invariant and
formulate new effective semi-analytic algorithm to model the scalar turbulence.
We then carry massive numerics of passive scalar turbulence with the focus on
the statistics of nodal lines. The distribution of contours over sizes and
perimeters is shown to depend neither on the flow realization nor on the
resolution (diffusion) scale for scales exceeding . The scalar
isolines are found fractal/smooth at the scales larger/smaller than the pumping
scale . We characterize the statistics of bending of a long isoline by the
driving function of the L\"owner map, show that it behaves like diffusion with
the diffusivity independent of resolution yet, most surprisingly, dependent on
the velocity realization and the time of scalar evolution
Large enhancement of deuteron polarization with frequency modulated microwaves
We report a large enhancement of 1.7 in deuteron polarization up to values of
0.6 due to frequency modulation of the polarizing microwaves in a two liters
polarized target using the method of dynamic nuclear polarization. This target
was used during a deep inelastic polarized muon-deuteron scattering experiment
at CERN. Measurements of the electron paramagnetic resonance absorption spectra
show that frequency modulation gives rise to additional microwave absorption in
the spectral wings. Although these results are not understood theoretically,
they may provide a useful testing ground for the deeper understanding of
dynamic nuclear polarization.Comment: 10 pages, including the figures coming in uuencoded compressed tar
files in poltar.uu, which also brings cernart.sty and crna12.sty files neede
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