Multi-objective optimization of RF circuit blocks via surrogate models and NBI and SPEA2 methods

Multi-objective optimization techniques can be categorized globally into deterministic and evolutionary methods. Examples of such methods are the Normal Boundary Intersection (NBI) method and the Strength Pareto Evolutionary Algorithm (SPEA2), respectively. With both methods one explores trade-offs between conflicting performances. Surrogate models can replace expensive circuit simulations so enabling faster computation of circuit performances. As surrogate models of behavioral parameters and performance outcomes, we consider look-up tables with interpolation and Neural Network models

MinerAlert: an hybrid approach for web mining detection

The introduction of new memory-based crypto-mining techniques and the rise of new web technologies like WebAssembly, made the use of browsers for crypto-currencies mining more and more convenient and popular. That, in turn, originated a new form of computer piracy, called cryptojacking, which is rapidly gaining ground on the web. A cryptojacking site exploits its visitors’ hardware resources to secretly mine crypto-currencies. This paper analyzes current web-based cryptojacking detection methods in order to propose a novel hybrid strategy. Current detection methods are found to require either considerable computer administration skills or execution privileges usually not available to common users. In this view, a method, named MinerAlert, has been designed and proposed, aiming at detecting in real-time sites performing cryptojacking. To address the limitations of current methods, the method implementation has been achieved through a browser extension. The present paper describes the method’s details and its implementation. It also reports the experimental results of its utilization, showing its positive performances in terms of ease of use, successful detections and speed

Recent Clinical and Preclinical Studies of Hydroxychloroquine on RNA Viruses and Chronic Diseases: A Systematic Review

The rapid spread of the new Coronavirus Disease 2019 (COVID-19) has actually become the newest challenge for the healthcare system since, to date, there is not an effective treatment. Among all drugs tested, Hydroxychloroquine (HCQ) has attracted significant attention. This systematic review aims to analyze preclinical and clinical studies on HCQ potential use in viral infection and chronic diseases. A systematic search of Scopus and PubMed databases was performed to identify clinical and preclinical studies on this argument; 2463 papers were identified and 133 studies were included. Regarding HCQ activity against COVID-19, it was noticed that despite the first data were promising, the latest outcomes highlighted the ineffectiveness of HCQ in the treatment of viral infection. Several trials have seen that HCQ administration did not improve severe illness and did not prevent the infection outbreak after virus exposure. By contrast, HCQ arises as a first-line treatment in managing autoimmune diseases such as rheumatoid arthritis, lupus erythematosus, and Sjögren syndrome. It also improves glucose and lipid homeostasis and reveals significant antibacterial activity

A practical method for gas changing time estimation using a simple gas-liquid mass transfer model

The present work explains a practical and simple method to calculate the gas changing time of anaerobic systems. It is substantiated under the physics of gas-liquid transfer theory and allows researchers to obtain an approximate value of gas changing time with few measurements of the gas composition in the outlet of the reactor. The only analytical equipment required is a gas analyzer, and calculations can be done using a spreadsheet. Along with the validation of the model, a short guide for its application in the laboratory is introduced. The model fits the experimental data with less than 1% error in the composition of the out-gas when no carbon dioxide is involved. This method will allow savings in valuable resources such as time and gases while providing greater comprehension of the characteristics of the gas-liquid transfer of the studied system

Effects of irrigation on n2o emissions in a maize crop grown on different soil types in two contrasting seasons

Crop management and soil properties affect greenhouse gas (GHG) emissions from cropping systems. Irrigation is one of the agronomical management practices that deeply affects soil nitrous oxide (N2O) emissions. Careful management of irrigation, also concerning to soil type, might mitigate the emissions of this powerful GHG from agricultural soils. In the Mediterranean area, despite the relevance of the agricultural sector to the overall economy and sustainable development, the topic of N2O emissions does not have the same importance as N2O fluxes in temperate agricultural areas. Only some research has discussed N2O emissions from Mediterranean cropping systems. Therefore, in this study, N2O emissions from different soil types (sandy‐loam and clay soils) were analyzed in relation to the irrigation of a maize crop grown in two contrasting seasons (2009–2010). The irrigation was done using a center pivot irrigation system about twice a week. The N2O emissions were monitored throughout the two‐years of maize crop growth. The emissions were measured with the accumulation technique using eight static chambers (four chambers per site). Nitrogen fertilizer was applied in the form of ammonium sulphate and urea with 3,4 dimethylpyrazole phosphate (DMPP) nitrification inhibitors. In 2009, the N2O emissions and crop biomass measured in both soil types were lower than those measured in 2010. This situation was a lower amount of water and nitrogen (N) available to the crop. In 2010, the N2O fluxes were higher in the clay site than those in the sandy‐loam site after the first fertilization, whereas an opposite trend was found after the second fertilization. The soil temperature, N content, and soil humidity were the main drivers for N2O emission during 2009, whereas during 2010, only the N content and soil humidity affected the nitrous oxide emissions. The research has demonstrated that crop water management deeply affects soil N2O emissions, acting differently for denitrification and nitrification. The soil properties affect N2O emission by influencing the microclimate conditions in the root zone, conditioning the N2O production

Fluid-Enhanced Annealing in the Subcontinental Lithospheric Mantle Beneath the Westernmost Margin of the Carpathian-Pannonian Extensional Basin System

Mantle xenoliths from the Styrian Basin Volcanic Field (Western Pannonian Basin, Austria) are mostly coarse granular amphibole-bearing spinel lherzolites with microstructures attesting for extensive annealing. Olivine and pyroxene CPO (crystal-preferred orientation) preserve nevertheless the record of coeval deformation during a preannealing tectonic event. Olivine shows transitional CPO symmetry from [010]-fiber to orthogonal type. In most samples with [010]-fiber olivine CPO symmetry, the [001] axes of the pyroxenes are also dispersed in the foliation plane. This CPO patterns are consistent with lithospheric deformation accommodated by dislocation creep in a transpressional tectonic regime. The lithospheric mantle deformed most probably during the transpressional phase after the Penninic slab breakoff in the Eastern Alps. The calculated seismic properties of the xenoliths indicate that a significant portion of shear wave splitting delay times in the Styrian Basin (0.5 s out of approximately 1.3 s) may originate in a highly annealed subcontinental lithospheric mantle. Hydroxyl content in olivine is correlated to the degree of annealing, with higher concentrations in the more annealed textures. Based on the correlation between microstructures and hydroxyl content in olivine, we propose that annealing was triggered by percolation of hydrous fluids/melts in the shallow subcontinental lithospheric mantle. A possible source of these fluids/melts is the dehydration of the subducted Penninic slab beneath the Styrian Basin. The studied xenoliths did not record the latest large-scale geodynamic events in the regionthe Miocene extension then tectonic inversion of the Pannonian Basin.We acknowledge the constructive criticism and helpful comments of Q‐K. Xia, an anonymous reviewer, and the Editor, John Geissman. We are grateful to F. Barou for his assistance during EBSD‐SEM analyses. L. E. Aradi is grateful to Bernardo Cesare, Levente Patkó, and Raúl Carampin for their help during the EPMA measurements. The FTIR analyses were carried out with the help of Judith Mihály and Csaba Németh. This research was partially granted by the Hungarian Science Foundation (OTKA, 78425 to Cs. Szabó). K. H.'s work was funded by the European Union Seventh Framework Programme Marie Curie postdoctoral fellowship (grant PIEFGA‐2012‐327226) and by the Juan de la Cierva Postdoctoral Fellowship (grant FPDI‐2013‐16253) of the Spanish Ministry of Economic and Competitiveness (MINECO). This project has been implemented with the support provided to I. J. Kovács from the National Research, Development and Innovation Fund of Hungary, financed under the K119740 funding scheme. The data used in this paper are listed in the references, tables, and supporting information. The raw EBSD and geochemical data are available from the corresponding author upon request. The FTIR spectra are available at the PULI (Pannonian Uniform Lithospheric Infrared spectral database) website (http://puli.mfgi.hu/). This is the 86 publication of the Lithosphere Fluid Research Lab (LRG)

Impact of ploidy change on secondary metabolites and photochemical efficiency in Solanum bulbocastanum Dun.

Plants are well known for producing a wide diversity of natural compounds and several strategies have been proposed to enhance their production. Among them, somatic chromosome doubling may represent an effective and inexpensive method. The objective of the current study was to investigate the effect of polyploidization on the leaf metabolic profile and content of tetraploids produced from a wild diploid (2n=2x=24) potato species, Solanum bulbocastanum Dun. Photochemical efficiency of tetraploids was also analyzed. Results from HPLC-DAD and LC/MS analyses provided evidence that tetraploid genotypes displayed either a similar or a lower phenylpropanoids, tryptophan, tyrosine and α-chaconine content compared with the diploid parent. Similarly, no significant differences were found among genotypes both for measures of gas and for chlorophyll fluorescence, except for non-photochemical quenching (NPQ). Steroidal saponins content revealed superiority of some tetraploids with respect to the diploid parent, suggesting perturbations in the mechanism regulating the biosynthesis of such compounds following polyploidization. Lack of superiority may be attributed to the time required for adjustment, adaptation and evolution after the genomic shock induced by polyploidization, as well as the fact that an optimum ploidy level for each species may be crucial. Our results suggest that polyploidization as a strategy to enhance metabolite production cannot be generalized

The ligand-receptor interactions based on silicon technology

We explored the use of porous silicon (pSi) technology for the construction of a biotechnological device, in which the ligand-receptor interactions are revealed by means of laser optical measurements. Here we report the settling of chemical procedures for the functionalization of the silicon wafers and for the subsequent anchoring of biological molecules such as a purified murine monoclonal antibody (UN1 mAb), an antibody anti-P8 protein of M13 phage and an antibody anti-A20 murine lymphoma cell line. The optical analysis of the interaction on the biochips between the bound biomolecules and their corresponding ligands indicated that the pSi is suitable for thi

Secondary metabolite profile in induced tetraploids of wild Solanum commersonii Dun.

The main aim of this work was to study the leaf secondary metabolite profiles of artificially induced tetraploids (2n1⁄44x1⁄448) of Solanum commersonii, a diploid (2n1⁄42x1⁄424) wild potato species. The tetraploid genotypes of S. commersonii were produced by oryzalin treatment. Both HPLC-UV and LC/ MS analyses revealed that there were no qualitative differences in the metabolite profiles between the diploid S. commersonii and its tetraploids. By contrast, the results showed that the phenylpropanoid content was generally significantly higher in the tetraploids than in the diploid S. commersonii. Concerning the glycoalkaloids (GAs), the results provided evidence that the content of minor GAs (solanidenediol triose, solanidadienol lycotetraose, and solanidenol lycotetraose) was higher in tetraploids than in the diploid progenitor, while the content of major GAs (dehydrodemissine and dehydrocommersonine) was significantly higher in diploid S. commersonii than in its tetraploid genotypes. The results are discussed from the practical perspective of potato biodiversity enhancement

Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps.

Histone deimination regulates gene function and contributes to antimicrobial response, allowing the formation of neutrophil extracellular traps (NETs). Deiminated proteins are target of anti-citrullinated peptides antibodies (ACPA) in rheumatoid arthritis (RA). OBJECTIVE: The objective of this paper is to test the hypothesis that RA sera react with deiminated histones contained in NETs. METHODS: Neutrophils from peripheral blood were stimulated with A23187 and acid treated; NETosis was induced by phorbol myristate acetate, and NET proteins were isolated. Sera were tested by immunoblot on acid extracted proteins from neutrophils and from NETs, and by ELISA on deiminated histone H4 or H4-derived peptides. Bands reactive with RA sera were excised from gels, digested with trypsin and subjected to matrix-assisted laser desorption/ionisation time of flight (MALDI-TOF) analysis, before and after derivatisation to detect citrullinated peptides. RESULTS: RA sera reacted with a deiminated antigen of 11 KDa from activated neutrophils, recognised also by anti-H4 and antideiminated H4 antibodies. A similar reactivity was observed with NET proteins. The antigen from neutrophils or NETs was identified as citrullinated H4 by MALDI-TOF analysis. By ELISA, RA sera bound in vitro citrullinated H4. Citrullinated H4 14-34 and 31-50 peptides detected antibodies in 67% and 63% of RA sera and in less than 5% of controls; antibody titre was correlated with anti-CCP2. CONCLUSIONS: Citrullinated H4 from activated neutrophils and NETs is a target of antibodies in RA, and synthetic citrullinated H4-derived peptides are a new substrate for ACPA detection. As NETosis can generate antigens for ACPA, these data suggest a novel connection between innate and adaptive immunity in RA