~115 GeV and ~143 GeV Higgs mass considerations within the Composite Particles Model

The radiatively generated Higgs mass is obtained by requiring that leading "divergences" are cancelled in both 2D and 4D. This predicts one or more viable modes; the k=1 mode mass is m_H\cong2/3 m_t\cong115GeV whereas the k=2 mode is m_H\cong143GeV. These findings are interpreted within the Composite Particles Model (CPM), [Popovic 2002, 2010], with the massive top quark being a composite structure composed of 3 fundamental O quarks (O\bar{O}O) and the massive Higgs scalar being a color-neutral meson like structure composed of 2 fundamental O quarks (\bar{O}O). The CPM predicts that the Z mass generation is mediated primarily by a top - anti top whereas the Higgs mass is generated primarily by a O - anti O interactions. The relationship [Popovic 2010] between top Yukawa coupling and strong QCD coupling, obtained by requiring that top - anti top channel is neither attractive or repulsive at tree level at \surd s\congM_Z, defines the Z mass. In addition, this relationship indirectly defines the electroweak symmetry breaking (EWSB) vacuum expectation value (VEV), the CPM Higgs mass and potentially the EWSB scale.Comment: 11 pages, 3 figures, slightly updated second version: Lagrangian explicitly specified, OOO->O\bar{O}O and a few other typos correcte

Российская и зарубежная практика развития моделей финансирования медицинских услуг

The relevance of the topic chosen due to the need to choose the path of development of the health system and in particular the development and implementation of the most efficient model of financing guaranteed by the state medical services in competitive relationships on the basis of accessibility, adaptability and quality. Currently, the authorities pay special attention to the transition to a more efficient model of distribution of financial resources, and health care institutions are interested in finding additional sources of funding.Актуальность выбранной темы обусловлена необходимостью выбора пути развития системы здравоохранения и в частности разработки и применения наиболее эффективной модели финансирования, гарантированных государством медицинских услуг населению в условиях конкурентных отношений и на основе доступности, технологичности и высокого качества. В настоящее время органы власти особое внимание уделяют переходу к наиболее эффективной модели распределения финансовых средств, а лечебно-профилактические учреждения заинтересованы в поиске дополнительных источников финансирования

Adaptive pseudolinear compensators of dynamic characteristics of automatic control systems

Adaptive pseudolinear gain and phase compensators of dynamic characteristics of automatic control systems are suggested. The automatic control system performance with adaptive compensators has been explored. The efficiency of pseudolinear adaptive compensators in the automatic control systems with time-varying parameters has been demonstrated

Nucleolar Localization of GLTSCR2/PICT-1 Is Mediated by Multiple Unique Nucleolar Localization Sequences

The human glioma tumor suppressor candidate region 2 gene product, GLTSCR2, also called ‘protein interacting with carboxyl terminus 1’ (PICT-1), has been implicated in the regulation of two major tumor suppressor proteins, PTEN and p53, and reported to bind the membrane-cytoskeleton regulator of cell signaling, Merlin. PICT-1 is a nucleolar protein, conserved among eukaryotes, and its yeast homolog has been functionally associated with ribosomal RNA processing. By means of confocal microscopy of EGFP and myc-tagged PICT-1 fusion proteins, we delineate that the nucleolar localization of PICT-1 is mediated by two independent nucleolar localization sequences (NoLS). Unlike most NoLSs, these NoLSs are relatively long with flexible boundaries and contain arginine and leucine clusters. In addition, we show that PICT-1 exhibits a nucleolar distribution similar to proteins involved in ribosomal RNA processing, yet does not colocalize precisely with either UBF1 or Fibrillarin under normal or stressed conditions. Identification of the precise location of PICT-1 and the signals that mediate its nucleolar localization is an important step towards advancing our understanding of the demonstrated influence of this protein on cell fate and tumorigenesis

Russian and foreign pra ctice of financing models of health servi ces

The relevance of the topic chosen due to the need to choose the path of development of the health system and in particular the development and implementation of the most efficient model of financing guaranteed by the state medical services in competitive relationships on the basis of accessibility, adaptability and quality. Currently, the authorities pay special attention to the transition to a more efficient model of distribution of financial resources, and health care institutions are interested in finding additional sources of funding

THERAPEUTIC DRUG MONITORING OF ANTICONVULSANTS IN CHILDREN IN CLINICAL PRACTICE

Objective. To study concentration of valproats in children with epilepsy, newborns  and infants with episyndrome  using therapeutic drug monitoring (TDM) in routine clinical practice. Materials and  methods. 75 children aged 1-18 years and 59 preterm newborns aged 0-90 days receiving valproic acid drugs were included in the study. Valproic acid concentration was measured using high performance liquid chromatography (HРLC). Results. Therapeutic concentration was achieved in 77.3%  of  children  aged  1-18  years  with  an  average  daily dose  of  25.94  mg/kg  (1021.4  mg);  overtherapeutic concentrations  were registered  in 9.3%  of the cases.  Concentration of valproic acid tended  to decrease  along with children’s age. Among children aged 1-18, a direct correlation between the daily dose (in mg/kg) and concentrations  of  valproates was observed: r=0.42 for Cmin and r=0.50 for Cmax. There was no correlation between age and concentration. In newborns,  therapeutic concentration  was achieved only in 33.9% of the cases  with an average daily dose  of 43.4 mg/kg  (82.6  mg); overtherapeutic  concentrations  were registered  in 11.9%  of the  cases.  Significant  differences  in average daily doses  and concentrations of valproic acid were found in newborns under 1 month of age; overtherapeutic concentrations  in the group of preterm newborns  under 1 month were observed  in 23.5% of the cases versus 9.5% in the group of newborns  of 2-3 months  of age (p=0.07).  Weak inverse  correlation between  age and concentration  of valproic acid was seen in newborns: r=-0.25 for Cmin and r=-0.24 for Cmax. There was no correlation between the dose and concentration of valproic acid, this explains unpredictability of the dose response  in the group of preterm newborns and low rates of achieving therapeutic concentrations.  Conclusion. Specific features of valproic acid pharmacokinetics  in newborns  and children are associated  with specific TDM parameters identified within the study; these  findings show high value of TDM

RESULTS OF THERAPEUTIC DRUG MONITORING COMBINATION THERAPY OF ANTICONVULSANTS IN CLINICAL PRACTICS

Abstract: this paper presents the results of therapeutic drug monitoring (TDM) of anticonvulsants – valproats and carbamazepins. Analysis include 800 patients with epilepsy in clinical practices, who received monotherapy and drug combinations. We determine plasma concentrations in two points: Cmin – before use next dose and Cmax – after next dose; concentration range for valproats – 50-150 mg/l, for carbamazepin – 4-12 mg/l. Plasma concentrations of valproats was statistically low in combination with carbamazepins than in monotherapy: Cmin 44,1±1,4 versus 62.1±2.0 (р<0,001) и Cmax 57.6±1.9 versus 76.5±2.4, without differences in daily doses. The frequency of achievement the therapeutic concentrations of valproats on valproat/carbamazepin combination was 34% versus 67% in monotherapy as result of inducing metabolism valproate acid by carbamazepin. For carbamazepin there was tendency for high frequency of achievement the therapeutic concentrations on combination treatment than on monotherapy – 86% versus 75.9%, but the doses of carbamazepin were also higher in combination therapy. However, plasma concentrations of carbamazepin were statistically higher only in combinations with other anticonvulsants exclude valproats: Cmin 8.0±0.2 versus 6.1±0.16 и Cmax 9.4±0.2 versus 7.3±0.18 (р<0,001) in monotherapy. The frequency of achievement the therapeutic concentrations for valproats and carbamazepin simultaneously in combination therapy was only 28.5%. This demonstrate the level of drug interactions in combination therapy of epilepcy especially with valproats and carbamazepin