Mechanical compatibility of sol–gel annealing with titanium for orthopaedic prostheses

Sol–gel processing is an attractive method for large-scale surface coating due to its facile and inexpensive preparation, even with the inclusion of precision nanotopographies. These are desirable traits for metal orthopaedic prostheses where ceramic coatings are known to be osteoinductive and the effects may be amplified through nanotexturing. However there are a few concerns associated with the application of sol–gel technology to orthopaedics. Primarily, the annealing stage required to transform the sol–gel into a ceramic may compromise the physical integrity of the underlying metal. Secondly, loose particles on medical implants can be carcinogenic and cause inflammation so the coating needs to be strongly bonded to the implant. These concerns are addressed in this paper. Titanium, the dominant material for orthopaedics at present, is examined before and after sol–gel processing for changes in hardness and flexural modulus. Wear resistance, bending and pull tests are also performed to evaluate the ceramic coating. The findings suggest that sol–gel coatings will be compatible with titanium implants for an optimum temperature of 500 °C

Supporting reinterpretation in computer-aided conceptual design

This paper presents research that aims to inform the development of computational tools that better support design exploration and idea transformation - key objectives in conceptual design. Analyses of experimental data from two fields - product design and architecture - suggest that the interactions of designers with their sketches can be formalised according to a finite number of generalised shape rules defined within a shape grammar. Such rules can provide a basis for the generation of alternative design concepts and they have informed the development of a prototype shape synthesis system that supports dynamic reinterpretation of shapes in design activity. The notion of 'sub-shapes' is introduced and the significance of these to perception, recognition and the development of emergent structures is discussed. The paper concludes with some speculation on how such a system might find application in a range of design fields

Gauge-Fixing and Residual Symmetries in Gauge/Gravity Theories with Extra Dimensions

We study compactified pure gauge/gravitational theories with gauge-fixing terms and show that these theories possess quantum mechanical SUSY-like symmetries between unphysical degrees of freedom. These residual symmetries are global symmetries and generated by quantum mechanical N=2 supercharges. Also, we establish new one-parameter family of gauge choices for higher-dimensional gravity, and calculate as a check of its validity one graviton exchange amplitude in the lowest tree-level approximation. We confirm that the result is indeed $\xi$-independent and the cancellation of the $\xi$-dependence is ensured by the residual symmetries. We also give a simple interpretation of the vDVZ-discontinuity, which arises in the lowest tree-level approximation, from the supersymmetric point of view.Comment: REVTeX4, 17 pages, 1 figur

Impact of Caesarean section on subsequent fertility: a systematic review and meta-analysis.

STUDY QUESTION: Is there an association between a Caesarean section and subsequent fertility? SUMMARY ANSWER: Most studies report that fertility is reduced after Caesarean section compared with vaginal delivery. However, studies with a more robust design show smaller effects and it is uncertain whether the association is causal. WHAT IS KNOWN ALREADY: A previous systematic review published in 1996 summarizing six studies including 85 728 women suggested that Caesarean section reduces subsequent fertility. The included studies suffer from severe methodological limitations. STUDY DESIGN, SIZE, DURATION: Systematic review and meta-analysis of cohort studies comparing subsequent reproductive outcomes of women who had a Caesarean section with those who delivered vaginally. PARTICIPANTS/MATERIALS, SETTING, METHODS: Searches of Cochrane Library, Medline, Embase, CINAHL Plus and Maternity and Infant Care databases were conducted in December 2011 to identify randomized and non-randomized studies that compared the subsequent fertility outcomes after a Caesarean section and after a vaginal delivery. Eighteen cohort studies including 591 850 women matched the inclusion criteria. Risk of bias was assessed by the Newcastle-Ottawa scale (NOS). Data extraction was done independently by two reviewers. The meta-analysis was based on a random-effects model. Subgroup analyses were performed to assess whether the estimated effect was influenced by parity, risk adjustment, maternal choice, cohort period, and study quality and size. MAIN RESULTS AND THE ROLE OF CHANCE: The impact of Caesarean section on subsequent pregnancies could be analysed in 10 studies and on subsequent births in 16 studies. A meta-analysis suggests that patients who had undergone a Caesarean section had a 9% lower subsequent pregnancy rate [risk ratio (RR) 0.91, 95% confidence interval (CI) (0.87, 0.95)] and 11% lower birth rate [RR 0.89, 95% CI (0.87, 0.92)], compared with patients who had delivered vaginally. Studies that controlled for maternal age or specifically analysed primary elective Caesarean section for breech delivery, and those that were least prone to bias according to the NOS reported smaller effects. LIMITATIONS, REASONS FOR CAUTION: There is significant variation in the design and methods of included studies. Residual bias in the adjusted results is likely as no study was able to control for a number of important maternal characteristics, such as a history of infertility or maternal obesity. WIDER IMPLICATIONS OF THE FINDINGS: Further research is needed to reduce the impact of selection bias by indication through creating more comparable patient groups and applying risk adjustment

Transport properties of a molecule embedded in an Aharonov-Bohm interferometer

We theoretically investigate the transport properties of a molecule embedded in one arm of a mesoscopic Aharonov-Bohm interferometer. Due to the presence of phonons the molecule level position ($\epsilon_d$) and the electron-electron interaction ($U$) undergo a \emph{polaronic shift} which affects dramatically the electronic transport through the molecular junction. When the electron-phonon interaction is weak the linear conductance presents Fano-line shapes as long as the direct channel between the electrodes is opened. The observed Fano resonances in the linear conductance are originated from the interference between the spin Kondo state and the direct path. For strong enough electron-phonon interaction, the electron-electron interaction is renormalized towards negative values, {\it i.e.} becomes effectively attractive. This scenario favors fluctuations between the empty and doubly occupied charge states and therefore promotes a charge Kondo effect. However, the direct path between the contacts breaks the electron-hole symmetry which can efficiently suppress this charge Kondo effect. Nevertheless, we show that a proper tuning of the gate voltage is able to revive the Kondo resonance. Our results are obtained by using the Numerical Renormalization approximation to compute the electronic spectral function and the linear conductance.Comment: 17 pages, 12 figure

Discordant transmission of bacteria and viruses from mothers to babies at birth

BACKGROUND: The earliest microbial colonizers of the human gut can have life-long consequences for their hosts. Precisely how the neonatal gut bacterial microbiome and virome are initially populated is not well understood. To better understand how the maternal gut microbiome influences acquisition of the infant gut microbiome, we studied the early life bacterial microbiomes and viromes of 28 infant twin pairs and their mothers. RESULTS: Infant bacterial and viral communities more closely resemble those of their related co-twin than unrelated infants. We found that 63% of an infant\u27s bacterial microbiome can be traced to their mother\u27s gut microbiota. In contrast, only 15% of their viral communities are acquired from their mother. Delivery route did not determine how much of the bacterial microbiome or virome was shared from mother to infant. However, bacteria-bacteriophage interactions were altered by delivery route. CONCLUSIONS: The maternal gut microbiome significantly influences infant gut microbiome acquisition. Vertical transmission of the bacterial microbiome is substantially higher compared to vertical transmission of the virome. However, the degree of similarity between the maternal and infant gut bacterial microbiome and virome did not vary by delivery route. The greater similarity of the bacterial microbiome and virome between twin pairs than unrelated twins may reflect a shared environmental exposure. Thus, differences of the inter-generation transmissibility at birth between the major kingdoms of microbes indicate that the foundation of these microbial communities are shaped by different rules. Video Abstract

Managing peer relationships online - Investigating the use of Facebook by juvenile delinquents and youths-at-risk

10.1016/j.chb.2012.04.025Computers in Human Behavior2918-15CHBE

Numerical renormalization group calculation of near-gap peaks in spectral functions of the Anderson model with superconducting leads

We use the numerical renormalization group method (NRG) to investigate a single-impurity Anderson model with a coupling of the impurity to a superconducting host. Analysis of the energy flow shows, in contrast to previous belief, that NRG iterations can be performed up to a large number of sites, corresponding to energy differences far below the superconducting gap. This allows us to calculate the impurity spectral function very accurately for frequencies near the gap edge, and to resolve, in a certain parameter regime, sharp peaks in the spectral function close to the gap edge.Comment: 18 pages, 7 figures, accepted for publication in Journal of Physics: Condensed Matte