Comparison of Howland and General Impedance Converter (GIC) circuit based current sources for bio-impedance measurements

The current source is a key component in bio-impedance measurement systems. The accuracy of the current source can be measured in terms of its output impedance together with other parameters, with certain applications demanding extremely high output impedance. This paper presents an investigation and comparison of different current source designs based on the Enhanced Howland circuit combined with a General Impedance Converter (GIC) circuit using both ideal and non-ideal operational amplifiers. Under differing load conditions two different settings of the GIC are evaluated and the results are compared to show its performance settings. Whilst the study has shown that over a wide bandwidth (i.e. 100Hz-100MHz) the output impedance is limited, operation over a more limited range offers output impedance in the Giga-ohm range, which can be considered as being infinite

Product rule for gauge invariant Weyl symbols and its application to the semiclassical description of guiding center motion

We derive a product rule for gauge invariant Weyl symbols which provides a generalization of the well-known Moyal formula to the case of non-vanishing electromagnetic fields. Applying our result to the guiding center problem we expand the guiding center Hamiltonian into an asymptotic power series with respect to both Planck's constant $\hbar$ and an adiabaticity parameter already present in the classical theory. This expansion is used to determine the influence of quantum mechanical effects on guiding center motion.Comment: 24 pages, RevTeX, no figures; shortened version will be published in J.Phys.

The large-scale energetic ion layer in the high latitude Jovian magnetosphere as revealed by Ulysses/HI-SCALE cross-field intensity-gradient measurements

Ulysses investigated the high latitude Jovian magnetosphere for a second time after Pioneer 11 mission and gave us the opportunity to search the structure and the dynamics of this giant magnetosphere above the magnetodisc. Kivelson(1976) and Kennel & Coroniti(1979) reported that Pioneer 11 observed energetic particle intensities at high latitudes at the same level with those measured in the plasma sheet and inferred that they were not consistent with the magnetodisc model. Ulysses observations supported the idea about a large-scale layer of energetic ions and electrons in the outer high latitude Jovian magnetosphere (Cowley et al.1996; Anagnostopoulos et al. 2001). This study perform a number of further tests for the existence of the large scale layer of energetic ions in the outer high latitude Jovian magnetosphere by studying appropriate cross-B field anisotropies in order to monitor the ion northward/southward intensity gradients. In particular, we examined Ulysses/HI-SCALE observations of energetic ions with large gyro-radius (0.5-1.6MeV protons and >2.5MeV heavy(Z>5) ions) in order to compare instant intensity changes with remote sensing intensity gradients. Our analysis confirms the existence of an energetic particle layer in the north hemisphere, during the inbound trajectory of Ulysses traveling at moderate latitudes, and in the south high-latitude duskside magnetosphere, during the outbound segment of the spacecraft trajectory. Our Ulysses/HI-SCALE data analysis also provides evidence for the detection of an energetic proton magnetopause boundary layer during the outbound trajectory of the spacecraft. During Ulysses flyby of Jupiter the almost permanent appearance of alternative northward and southward intensity gradients suggests that the high latitude layer appeared to be a third major area of energetic particles, which coexisted with the radiation belts and the magnetodisc.Comment: 37 pages, 11 figures, 1 tabl

Expression of Interest: The Atmospheric Neutrino Neutron Interaction Experiment (ANNIE)

Submitted for the January 2014 Fermilab Physics Advisory Committee meetingSubmitted for the January 2014 Fermilab Physics Advisory Committee meetingSubmitted for the January 2014 Fermilab Physics Advisory Committee meetingSubmitted for the January 2014 Fermilab Physics Advisory Committee meetingNeutron tagging in Gadolinium-doped water may play a significant role in reducing backgrounds from atmospheric neutrinos in next generation proton-decay searches using megaton-scale Water Cherenkov detectors. Similar techniques might also be useful in the detection of supernova neutrinos. Accurate determination of neutron tagging efficiencies will require a detailed understanding of the number of neutrons produced by neutrino interactions in water as a function of momentum transferred. We propose the Atmospheric Neutrino Neutron Interaction Experiment (ANNIE), designed to measure the neutron yield of atmospheric neutrino interactions in gadolinium-doped water. An innovative aspect of the ANNIE design is the use of precision timing to localize interaction vertices in the small fiducial volume of the detector. We propose to achieve this by using early production of LAPPDs (Large Area Picosecond Photodetectors). This experiment will be a first application of these devices demonstrating their feasibility for Water Cherenkov neutrino detectors

Expression of Interest: The Atmospheric Neutrino Neutron Interaction Experiment (ANNIE)

Neutron tagging in Gadolinium-doped water may play a significant role in reducing backgrounds from atmospheric neutrinos in next generation proton-decay searches using megaton-scale Water Cherenkov detectors. Similar techniques might also be useful in the detection of supernova neutrinos. Accurate determination of neutron tagging efficiencies will require a detailed understanding of the number of neutrons produced by neutrino interactions in water as a function of momentum transferred. We propose the Atmospheric Neutrino Neutron Interaction Experiment (ANNIE), designed to measure the neutron yield of atmospheric neutrino interactions in gadolinium-doped water. An innovative aspect of the ANNIE design is the use of precision timing to localize interaction vertices in the small fiducial volume of the detector. We propose to achieve this by using early production of LAPPDs (Large Area Picosecond Photodetectors). This experiment will be a first application of these devices demonstrating their feasibility for Water Cherenkov neutrino detectors.Comment: Submitted for the January 2014 Fermilab Physics Advisory Committee meetin

Bacteremia After Prophylaxis II

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141639/1/jper0371.pd

Clinical trial of laronidase in Hurler syndrome after hematopoietic cell transplantation.

BackgroundMucopolysaccharidosis I (MPS IH) is a lysosomal storage disease treated with hematopoietic cell transplantation (HCT) because it stabilizes cognitive deterioration, but is insufficient to alleviate all somatic manifestations. Intravenous laronidase improves somatic burden in attenuated MPS I. It is unknown whether laronidase can improve somatic disease following HCT in MPS IH. The objective of this study was to evaluate the effects of laronidase on somatic outcomes of patients with MPS IH previously treated with HCT.MethodsThis 2-year open-label pilot study of laronidase included ten patients (age 5-13 years) who were at least 2 years post-HCT and donor engrafted. Outcomes were assessed semi-annually and compared to historic controls.ResultsThe two youngest participants had a statistically significant improvement in growth compared to controls. Development of persistent high-titer anti-drug antibodies (ADA) was associated with poorer 6-min walk test (6MWT) performance; when patients with high ADA titers were excluded, there was a significant improvement in the 6MWT in the remaining seven patients.ConclusionsLaronidase seemed to improve growth in participants <8 years old, and 6MWT performance in participants without ADA. Given the small number of patients treated in this pilot study, additional study is needed before definitive conclusions can be made

"Author! Author!" : Shakespeare and biography

Original article can be found at: http://www.informaworld.com/smpp/title~content=t714579626~db=all Copyright Informa / Taylor & Francis Group. DOI: 10.1080/17450910902764454Since 1996, not a year has passed without the publication of at least one Shakespeare biography. Yet for many years the place of the author in the practice of understanding literary works has been problematized, and even on occasions eliminated. Criticism reads the “works”, and may or may not refer to an author whose “life” contributed to their meaning. Biography seeks the author in the works, the personality that precedes the works and gives them their characteristic shape and meaning. But the form of literary biography addresses the unusual kind of “life” that puts itself into “works”, and this is particularly challenging where the “works” predominate massively over the salient facts of the “life”. This essay surveys the current terrain of Shakespeare biography, and considers the key questions raised by the medium: can we know anything of Shakespeare's “personality” from the facts of his life and the survival of his works? What is the status of the kind of speculation that inevitably plays a part in biographical reconstruction? Are biographers in the end telling us as much about themselves as they tell us about Shakespeare?Peer reviewe