Perturbations with angular momentum of Robinson-Trautman spacetimes

We study the possible asymptotically flat perturbations of Robinson-Trautman spacetimes. We differentiate between algebraically special perturbations and general perturbations. The equations that determine physically realistic spacetimes with angular momentum are presented.Comment: 23 pages, no figure

Photon rockets and the Robinson-Trautman geometries

We point out the relation between the photon rocket spacetimes and the Robinson Trautman geometries. This allows a discussion of the issues related to the distinction between the gravitational and matter energy radiation that appear in these metrics in a more geometrical way, taking full advantage of their asymptotic properties at null infinity to separate the Weyl and Ricci radiations, and to clearly establish their gravitational energy content. We also give the exact solution for the generalized photon rockets.Comment: 7 pages, no figures, LaTeX2

Estimates of the total gravitation radiation in the head-on black hole collision

We report on calculations of the total gravitational energy radiated in the head-on black hole collision, where we use the geometry of the Robinson-Trautman metrics.Comment: 10 pages, 2 figures, LaTeX2

Quasigroups, Asymptotic Symmetries and Conservation Laws in General Relativity

A new quasigroup approach to conservation laws in general relativity is applied to study asymptotically flat at future null infinity spacetime. The infinite-parametric Newman-Unti group of asymptotic symmetries is reduced to the Poincar\'e quasigroup and the Noether charge associated with any element of the Poincar\'e quasialgebra is defined. The integral conserved quantities of energy-momentum and angular momentum are linear on generators of Poincar\'e quasigroup, free of the supertranslation ambiguity, posess the flux and identically equal to zero in Minkowski spacetime.Comment: RevTeX4, 5 page

Total angular momentum from Dirac eigenspinors

The eigenvalue problem for Dirac operators, constructed from two connections on the spinor bundle over closed spacelike 2-surfaces, is investigated. A class of divergence free vector fields, built from the eigenspinors, are found, which, for the lowest eigenvalue, reproduce the rotation Killing vectors of metric spheres, and provide rotation BMS vector fields at future null infinity. This makes it possible to introduce a well defined, gauge invariant spatial angular momentum at null infinity, which reduces to the standard expression in stationary spacetimes. The general formula for the angular momentum flux carried away be the gravitational radiation is also derived.Comment: 34 pages, typos corrected, four references added, appearing in Class. Quantum Gra

Cellular Basis of Tissue Regeneration by Omentum

The omentum is a sheet-like tissue attached to the greater curvature of the stomach and contains secondary lymphoid organs called milky spots. The omentum has been used for its healing potential for over 100 years by transposing the omental pedicle to injured organs (omental transposition), but the mechanism by which omentum helps the healing process of damaged tissues is not well understood. Omental transposition promotes expansion of pancreatic islets, hepatocytes, embryonic kidney, and neurons. Omental cells (OCs) can be activated by foreign bodies in vivo. Once activated, they become a rich source for growth factors and express pluripotent stem cell markers. Moreover, OCs become engrafted in injured tissues suggesting that they might function as stem cells

Development of selective agonists and antagonists of P2Y receptors

Although elucidation of the medicinal chemistry of agonists and antagonists of the P2Y receptors has lagged behind that of many other members of group A G protein-coupled receptors, detailed qualitative and quantitative structure–activity relationships (SARs) were recently constructed for several of the subtypes. Agonists selective for P2Y1, P2Y2, and P2Y6 receptors and nucleotide antagonists selective for P2Y1 and P2Y12 receptors are now known. Selective nonnucleotide antagonists were reported for P2Y1, P2Y2, P2Y6, P2Y11, P2Y12, and P2Y13 receptors. At the P2Y1 and P2Y12 receptors, nucleotide agonists (5′-diphosphate derivatives) were converted into antagonists of nanomolar affinity by altering the phosphate moieties, with a focus particularly on the ribose conformation and substitution pattern. Nucleotide analogues with conformationally constrained ribose-like rings were introduced as selective receptor probes for P2Y1 and P2Y6 receptors. Screening chemically diverse compound libraries has begun to yield new lead compounds for the development of P2Y receptor antagonists, such as competitive P2Y12 receptor antagonists with antithrombotic activity. Selective agonists for the P2Y4, P2Y11, and P2Y13 receptors and selective antagonists for P2Y4 and P2Y14 receptors have not yet been identified. The P2Y14 receptor appears to be the most restrictive of the class with respect to modification of the nucleobase, ribose, and phosphate moieties. The continuing process of ligand design for the P2Y receptors will aid in the identification of new clinical targets

Activation of the P2X7 ion channel by soluble and covalently bound ligands

The homotrimeric P2X7 purinergic receptor has sparked interest because of its capacity to sense adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD) released from cells and to induce calcium signaling and cell death. Here, we examine the response of arginine mutants of P2X7 to soluble and covalently bound ligands. High concentrations of ecto-ATP gate P2X7 by acting as a soluble ligand and low concentrations of ecto-NAD gate P2X7 following ADP-ribosylation at R125 catalyzed by toxin-related ecto-ADP-ribosyltransferase ART2.2. R125 lies on a prominent cysteine-rich finger at the interface of adjacent receptor subunits, and ADP-ribosylation at this site likely places the common adenine nucleotide moiety into the ligand-binding pocket of P2X7

Nucleases as a barrier to gene silencing in the cotton boll weevil, Anthonomus grandis.

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