SINGULARITY OF THE OF ELECTROMAGNETIC WAVE PROPOGATION IN A PLANE-LAYER ENVIRONMENT AND ITS TRANSFORMATION IN SPIN IN THE NEIGHBORHOOD OF THE FREQUENCY OF ANTIFERROMAGNETIC RESONANCE IN FERROMAGNETS

Показано влияние гиротропии на процесс возбуждения спиновых волн электромагнитной при частотах антирезонанса вблизи ориентационного фазового перехода в неоднородной плоскослоистой среде. Резонансное поглощение электромагнитной энергии вблизи особенности является причиной возбуждения спиновых колебаний, которые устраняют расходимость, активируя распространение спиновой волны при учете ее дисперсии в тензоре магнитной восприимчивости.The influence of gyrotropy on the process of excitation of electromagnetic spin waves at antirezonance frequencies near the orientational phase transition in inhomogeneous plane-layered environment. Resonant absorption of electromagnetic energy near the singularity is the cause of the excitation of spin oscillations, which eliminate divergence, activating the propagation of the spin wave, taking into account its dispersion in the magnetic susceptibility tensor

Взаимосвязь аргирофильных белков ядрышкообразующих районов и антигена ki-67 с клинико-морфологическими параметрами и выживаемостью при аденокарциноме легкого

Argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) and Ki-67 antigen were investigated in patients with lung adenocarcinoma. Tumors with low and high content of Ag-NOR proteins and proliferation index (PI) Ki-67 were determined. The relationship between the Ag-NOR content and T and N parameters, tumor size of 3 cm or more and stage of the disease was found. High survival rates in patients with lung adenocarcinoma were associated with the low content of Ag-NOR proteins and PI Ki-67 and low survival rates were related to the high content of Ag-NOR proteins and PI Ki-67. The intermediate survival rates were related to the opposite values of the content of Ag-NOR proteins and PI Ki-67. The tumor size, N parameter and the content of Ag-NOR proteins had an independent effect on survival of patients. Survival was related to the size of the tumor in lung cancer patients having no lymph node involvement and it was related to the content of Ag-NOR proteins in cases with the presence of metastases. Mutual study of Ag-NOR proteins and antigen Ki-67 has differential diagnostic and prognostic value in lung adenocarcinoma.Исследованы аргирофильные белки, ассоциированные с ядрышкообразующими районами (Ag-ЯОР-белки) и антиген Ki-67 в аденокарциноме легкого. Определяли опухоли с низким и высоким содержанием Ag-ЯОР-белков и индекса метки (ИМ) Ki-67. Содержание Ag-ЯОР-белков имело связь с показателями Т, N, размером опухоли до 3 см и более, стадией заболевания. Выжи- ваемость больных аденокарциномой легкого лучше при опухолях с низким содержанием Ag-ЯОР-белков или ИМ Ki-67. Высокая выживаемость связана с низким содержанием Ag-ЯОР-белков и ИМ Ki-67, низкая – с высоким содержание Ag-ЯОР-белков и ИМ Ki-67, промежуточная – с противоположными значениями содержания Ag-ЯОР-белков и ИМ Ki-67. Размер опухоли, показатель N и содержание Ag-ЯОР-белков имели независимое влияние на прогноз выживаемости больных. При аденокарциноме легкого без метастазов в лимфатические узлы выживаемость связана с размером опухоли, при наличии метастазов – с содержанием Ag-ЯОР- белков. Взаимное исследование Ag-ЯОР-белков и антигена Ki-67 имеет дифференциально-диагностическое и прогностическое значение при аденокарциноме легкого

ГИСТОСПЕКТРОФОТОМЕТРИЧЕСКОЕ И ИММУНОГИСТОХИМИЧЕСКОЕ ИССЛЕДОВАНИЕ РЕНАЛЬНОЙ ИНТРАТУБУЛЯРНОЙ НЕОПЛАЗИИ В ПЕРИТУМОРОЗНОЙ ЗОНЕ РАКА ПОЧКИ

In this work displays renal intratubular neoplasia (RIN) in peritumourous zone of a renal carcinoma have been studied. The object of our work, are the operative materials of 42 patients. Middle age of patients has made 57,4 ± 1,4 year. Men was 25, women — 17. Characteristic of tubular epithelium in PZ a renal carcinoma have been studied morphofunctional by means of histological, histospectrophotometrical and immunohistochemistrical methods. It is shown, that in PZ tumors of a high degree displays, of RIN much more often, than in tumors of low degree anaplasia. In tumors of a high degree anaplasia in tubular epithelium PZ registered increasing of nucleus, ploidy and expression of AgNORs, Ki-67, p53 and bcl-2. The presence of displays RIN in tubular epithelium PZ at a renal carcinoma should be considered at surgery operations.В работе изучены проявления ренальной интратубулярной неоплазии (РИН) в перитуморозной зоне (ПЗ) рака почки. Материалом для исследования послужил операционный материал от 42 больных. Средний возраст пациентов составил 57,4 ± 1,4 года. Мужчин было 25, женщин — 17. С помощью гистологического, гистоспектрофотометрического и иммуногистохимического методов была исследована морфофункциональная характеристика эпителия канальцев в ПЗ рака почки. Показано, что в ПЗ опухолей высокой степени злокачественности проявления РИН встречались значительно чаще, чем при опухолях низких степеней анаплазии. В опухолях высокой степени анаплазии в эпителии канальцев ПЗ отмечали увеличение ядер, плоидности и экспрессии AgNORs, Ki-67, p53 и bcl-2. Наличие проявлений РИН в канальцевом эпителии ПЗ при раке почки следует учитывать при органосохраняющих операциях

ПРОГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ ИССЛЕДОВАНИЯ МАТРИКСНОЙ МЕТАЛЛОПРОТЕИНАЗЫ 9 ПРИ ПОЧЕЧНО-КЛЕТОЧНОМ РАКЕ

Objective: to assess matrix metalloproteinase 9 (MMP-9)  expression in renal cell carcinoma cells and cells of intratumoral inflammatory infiltrates depending on clinical and morphological characteristics and postoperative survival.Materials and methods. We evaluated MMP-expression in 108 renal cancer tissue specimens. The intensity of immunohistochemical staining was estimated by measuring integral optical density in cytoplasm.Results. We found that the integral optical density of MMP-9 immunostaining in tumor cells and cells of intratumoral inflammatory infiltrates correlates with important prognostic factors for renal cancer, including histological type of cancer, TNM stage, tumor size, Fuhrman nuclear grade, metastasis, and 5-year postoperative survival.Conclusion. Integral optical density of MMP-9 immunostaining is an additional prognostic factor for renal cell carcinoma.Цель исследования – изучение экспрессии матриксной металлопротеиназы 9 (ММП-9) в клетках почечно-клеточного рака и клетках интратуморального воспалительного инфильтрата в зависимости от клинико-морфологических параметров и послеоперационной выживаемости пациентов.Материалы и методы. Исследованы 108 препаратов рака почки. Экспрессию ММП-9  выявляли иммуногистохимически, ее выраженность оценивали путем вычисления интегральной оптической плотности в цитоплазмах клеток.Результаты. Показано, что интегральная оптическая плотность ММП-9  в клетках  опухоли и клетках  интратуморального воспалительного инфильтрата взаимосвязана с важными прогностическими факторами рака почки: гистологическим вариантом рака, стадией заболевания по TNM,  размером опухолевого узла, градацией по Фурману, наличием метастазов и 5-летней послеоперационной выживаемостью больных.Заключение. Исследование интегральной оптической плотности ММП-9 может служить дополнительным фактором прогноза почечно-клеточного рака

КЛИНИЧЕСКИЕ АСПЕКТЫ ОПУХОЛЕВОГО АНГИОГЕНЕЗА В ПЕРИТУМОРОЗНОЙ ЗОНЕ У БОЛЬНЫХ РАКОМ ПОЧКИ

The specific features of tumor angiogenesis were studied in cancer-adjacent kidney tissues. The activity of neoangionesis in the peritumor area (PA) was shown to depend on the biological properties of a tumor and to be highest in high-grade tumors. The density of the PA microcirculatory bed correlated with the most important prognostic parameters for renal cell carcinoma and therefore it might be used as an additional prognostic factor in kidney cancer.Изучены особенности опухолевого ангиогенеза в тканях, прилежащих к раку почки. Показано, что активность неоангиогенеза в перитуморозной зоне (ПЗ) зависела от биологических свойств опухоли и была наиболее высока в опухолях высокой степени злокачественности. Плотность микроциркуляторного русла в ПЗ коррелировала с важнейшими прогностическими параметрами карциномы почки и поэтому может быть использована в качестве дополнительного фактора прогноза при раке почки

RELATIONSHIP BETWEEN ARGYROPHILIC PROTEINS OF NUCLEOLAR ORGANIZER REGIONS AND ANTIGEN KI-67 WITH CLINICAL AND MORPHOLOGICAL PARAMETERS AND SURVIVAL IN LUNG ADENOCARCINOMA

Argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) and Ki-67 antigen were investigated in patients with lung adenocarcinoma. Tumors with low and high content of Ag-NOR proteins and proliferation index (PI) Ki-67 were determined. The relationship between the Ag-NOR content and T and N parameters, tumor size of 3 cm or more and stage of the disease was found. High survival rates in patients with lung adenocarcinoma were associated with the low content of Ag-NOR proteins and PI Ki-67 and low survival rates were related to the high content of Ag-NOR proteins and PI Ki-67. The intermediate survival rates were related to the opposite values of the content of Ag-NOR proteins and PI Ki-67. The tumor size, N parameter and the content of Ag-NOR proteins had an independent effect on survival of patients. Survival was related to the size of the tumor in lung cancer patients having no lymph node involvement and it was related to the content of Ag-NOR proteins in cases with the presence of metastases. Mutual study of Ag-NOR proteins and antigen Ki-67 has differential diagnostic and prognostic value in lung adenocarcinoma

HISTOSPECTROPHOTOMETRICAL AND IMMUNOHISTOCHEMISTRICAL RESEARCH OF RENAL INTRATUBULAR NEOPLASIA IN PERITUMOUROUS ZONE OF A RENAL CARCINOMA

In this work displays renal intratubular neoplasia (RIN) in peritumourous zone of a renal carcinoma have been studied. The object of our work, are the operative materials of 42 patients. Middle age of patients has made 57,4 ± 1,4 year. Men was 25, women — 17. Characteristic of tubular epithelium in PZ a renal carcinoma have been studied morphofunctional by means of histological, histospectrophotometrical and immunohistochemistrical methods. It is shown, that in PZ tumors of a high degree displays, of RIN much more often, than in tumors of low degree anaplasia. In tumors of a high degree anaplasia in tubular epithelium PZ registered increasing of nucleus, ploidy and expression of AgNORs, Ki-67, p53 and bcl-2. The presence of displays RIN in tubular epithelium PZ at a renal carcinoma should be considered at surgery operations

PROGNOSTIC VALUE OF MATRIX METALLOPROTEINASE 9 IN RENAL CELL CARCINOMA

Objective: to assess matrix metalloproteinase 9 (MMP-9)  expression in renal cell carcinoma cells and cells of intratumoral inflammatory infiltrates depending on clinical and morphological characteristics and postoperative survival.Materials and methods. We evaluated MMP-expression in 108 renal cancer tissue specimens. The intensity of immunohistochemical staining was estimated by measuring integral optical density in cytoplasm.Results. We found that the integral optical density of MMP-9 immunostaining in tumor cells and cells of intratumoral inflammatory infiltrates correlates with important prognostic factors for renal cancer, including histological type of cancer, TNM stage, tumor size, Fuhrman nuclear grade, metastasis, and 5-year postoperative survival.Conclusion. Integral optical density of MMP-9 immunostaining is an additional prognostic factor for renal cell carcinoma

HISTOSPECTROPHOTOMETRICAL AND IMMUNOHISTOCHEMISTRICAL RESEARCH OF RENAL INTRATUBULAR NEOPLASIA IN PERITUMOUROUS ZONE OF A RENAL CARCINOMA

In this work displays renal intratubular neoplasia (RIN) in peritumourous zone of a renal carcinoma have been studied. The object of our work, are the operative materials of 42 patients. Middle age of patients has made 57,4 ± 1,4 year. Men was 25, women — 17. Characteristic of tubular epithelium in PZ a renal carcinoma have been studied morphofunctional by means of histological, histospectrophotometrical and immunohistochemistrical methods. It is shown, that in PZ tumors of a high degree displays, of RIN much more often, than in tumors of low degree anaplasia. In tumors of a high degree anaplasia in tubular epithelium PZ registered increasing of nucleus, ploidy and expression of AgNORs, Ki-67, p53 and bcl-2. The presence of displays RIN in tubular epithelium PZ at a renal carcinoma should be considered at surgery operations

TUMOR ANGIOGENESIS IN THE PERITUMOR AREA IN KIDNEY CANCER PATIENTS: CLINICAL ASPECTS

The specific features of tumor angiogenesis were studied in cancer-adjacent kidney tissues. The activity of neoangionesis in the peritumor area (PA) was shown to depend on the biological properties of a tumor and to be highest in high-grade tumors. The density of the PA microcirculatory bed correlated with the most important prognostic parameters for renal cell carcinoma and therefore it might be used as an additional prognostic factor in kidney cancer