CP Violation in D0−D0‾D^0-\overline{D^0}Mixing

The existence of $D^0-\overline{D^0}$ mixing at a detectable level requires new physics, which effectively yields a $\Delta c = 2$ superweak interaction. In general this interaction may involve significant CP violation. For small values of the mixing it may be much easier to detect the CP-violating part of the mixing than the CP-conserving part.Comment: 3 pages, latex, no figure

B-Decay CP Asymmetries, Discrete Ambiguities and New Physics

The first measurements of CP violation in the $B$ system will likely probe $\sin 2\alpha$, $\sin 2\beta$ and $\cos 2\gamma$. Assuming that the CP angles $\alpha$, $\beta$ and $\gamma$ are the interior angles of the unitarity triangle, these measurements determine the angle set $(\alpha,\beta,\gamma)$ except for a twofold discrete ambiguity. If one allows for the possibility of new physics, the presence of this discrete ambiguity can make its discovery difficult: if only one of the two candidate solutions is consistent with constraints from other measurements in the $B$ and $K$ systems, one is not sure whether new physics is present or not. We review the methods used to resolve the discrete ambiguity and show that, even in the presence of new physics, they can usually be used to uncover this new physics. There are some exceptions, which we describe in detail. We systematically scan the parameter space and present examples of values of $(\alpha,\beta,\gamma)$ and the new-physics parameters which correspond to all possibilities. Finally, we show that if one relaxes the assumption that the bag parameters \BBd and \BK are positive, one can no longer definitively establish the presence of new physics.Comment: 29 pages, LaTeX, 1 figures, presentation substantially reworked, physics conclusions unchanged. This version will be published in Phys. Rev.

Trick or treat: the effect of placebo on the power of pharmacogenetic association studies

The genetic mapping of drug-response traits is often characterised by a poor signal-to-noise ratio that is placebo related and which distinguishes pharmacogenetic association studies from classical case-control studies for disease susceptibility. The goal of this study was to evaluate the statistical power of candidate gene association studies under different pharmacogenetic scenarios, with special emphasis on the placebo effect. Genotype/phenotype data were simulated, mimicking samples from clinical trials, and response to the drug was modelled as a binary trait. Association was evaluated by a logistic regression model. Statistical power was estimated as a function of the number of single nucleotide polymorphisms (SNPs) genotyped, the frequency of the placebo 'response', the genotype relative risk (GRR) of the response polymorphism, the strategy for selecting SNPs for genotyping, the number of individuals in the trial and the ratio of placebo-treated to drug-treated patients. We show that: (i) the placebo 'response' strongly affects the statistical power of association studies--even a highly penetrant drug-response allele requires at least a 500-patient trial in order to reach 80 per cent power, several-fold more than the value estimated by standard tools that are not calibrated to pharmacogenetics; (ii) the power of a pharmacogenetic association study depends primarily on the penetrance of the response genotype and, when this penetrance is fixed, power decreases for larger placebo effects; (iii) power is dramatically increased when adding markers; (iv) an optimal study design includes a similar number of placebo- and drug-treated patients; and (v) in this setting, straightforward haplotype analysis does not seem to have an advantage over single marker analysis

Utilizing the Boston Syncope Observation Management Pathway to Reduce Hospital Admission and Decrease Adverse Outcomes

Introduction: In an age of increasing scrutiny of each hospital admission, emergency department (ED) observation has been identified as a low-cost alternative. Prior studies have shown admission rates for syncope in the United States to be as high as 70%. However, the safety and utility of substituting ED observation unit (EDOU) syncope management has not been well studied. The objective of this study was to evaluate the safety of EDOU for the management of patients presenting to the ED with syncope and its efficacy in reducing hospital admissions. Methods: This was a prospective before-and-after cohort study of consecutive patients presenting with syncope who were seen in an urban ED and were either admitted to the hospital, discharged, or placed in the EDOU. We first performed an observation study of syncope management and then implemented an ED observation-based management pathway. We identified critical interventions and 30-day outcomes. We compared proportions of admissions and adverse events rates with a chisquared or Fisher’s exact test. Results: In the “before” phase, 570 patients were enrolled, with 334 (59%) admitted and 27 (5%) placed in the EDOU; 3% of patients discharged from the ED had critical interventions within 30 days and 10% returned. After the management pathway was introduced, 489 patients were enrolled; 34% (p\u3c0.001) of pathway patients were admitted while 20% were placed in the EDOU; 3% (p=0.99) of discharged patients had critical interventions at 30 days and 3% returned (p=0.001). Conclusion: A focused syncope management pathway effectively reduces hospital admissions and adverse events following discharge and returns to the ED. [West J Emerg Med. 2019;20(2)250–255.

CP Violation in \tau ->\nu\pi K_S and D->\pi K_S: The Importance of K_S-K_L Interference

The $B$-factories have measured CP asymmetries in the $\tau\to\pi K_S\nu$ and $D\to K_S\pi$ modes. The $K_S$ state is identified by its decay to two pions at a time that is close to the $K_S$ lifetime. Within the Standard Model and many of its extensions, the asymmetries in these modes come from CP violation in $K^0-\bar{K}^0$ mixing. We emphasize that the interference between the amplitudes of intermediate $K_S$ and $K_L$ is as important as the pure $K_S$ amplitude. Consequently, the measured asymmetries depend on the times over which the relevant decay rates are integrated and on features of the experiment.Comment: 4 pages, 4 figure

The energy flux into a fluidized granular medium at a vibrating wall

We study the power input of a vibrating wall into a fluidized granular medium, using event driven simulations of a model granular system. The system consists of inelastic hard disks contained between a stationary and a vibrating elastic wall, in the absence of gravity. Two scaling relations for the power input are found, both involving the pressure. The transition between the two occurs when waves generated at the moving wall can propagate across the system. Choosing an appropriate waveform for the vibrating wall removes one of these scalings and renders the second very simple.Comment: 5 pages, revtex, 7 postscript figure

New Physics and CP Violation in Singly Cabibbo Suppressed D Decays

We analyze various theoretical aspects of CP violation in singly Cabibbo suppressed (SCS) D-meson decays, such as $D \to K K,\pi \pi$. In particular, we explore the possibility that CP asymmetries will be measured close to the present level of experimental sensitivity of $O(10^{-2})$. Such measurements would signal new physics. We make the following points: (i) The mechanism at work in neutral D decays could be indirect or direct CP violation (or both). (ii) One can experimentally distinguish between these possibilities. (iii) If the dominant CP violation is indirect, then there are clear predictions for other modes. (iv) Tree-level direct CP violation in various known models is constrained to be much smaller than $10^{-2}$. (v) SCS decays, unlike Cabibbo favored or doubly Cabibbo suppressed decays, are sensitive to new contributions from QCD penguin operators and especially from chromomagnetic dipole operators. This point is illustrated with supersymmetric gluino-squark loops, which can yield direct CP violating effects of $O(10^{-2})$.Comment: 36 pages, 5 figure

Data and the city – accessibility and openness. a cybersalon paper on open data

This paper showcases examples of bottom–up open data and smart city applications and identifies lessons for future such efforts. Examples include Changify, a neighbourhood-based platform for residents, businesses, and companies; Open Sensors, which provides APIs to help businesses, startups, and individuals develop applications for the Internet of Things; and Cybersalon’s Hackney Treasures. a location-based mobile app that uses Wikipedia entries geolocated in Hackney borough to map notable local residents. Other experiments with sensors and open data by Cybersalon members include Ilze Black and Nanda Khaorapapong's The Breather, a "breathing" balloon that uses high-end, sophisticated sensors to make air quality visible; and James Moulding's AirPublic, which measures pollution levels. Based on Cybersalon's experience to date, getting data to the people is difficult, circuitous, and slow, requiring an intricate process of leadership, public relations, and perseverance. Although there are myriad tools and initiatives, there is no one solution for the actual transfer of that data

Turbulent convection: comparing the moment equations to numerical simulations

The non-local hydrodynamic moment equations for compressible convection are compared to numerical simulations. Convective and radiative flux typically deviate less than 20% from the 3D simulations, while mean thermodynamic quantities are accurate to at least 2% for the cases we have investigated. The moment equations are solved in minutes rather than days on standard workstations. We conclude that this convection model has the potential to considerably improve the modelling of convection zones in stellar envelopes and cores, in particular of A and F stars.Comment: 10 pages (6 pages of text including figure captions + 4 figures), Latex 2e with AAS Latex 5.0 macros, accepted for publication in ApJ

Evolutionary models for very-low-mass stars and brown dwarfs with dusty atmospheres

We present evolutionary calculations for very-low-mass stars and brown dwarfs based on synthetic spectra and non-grey atmosphere models which include dust formation and opacity, i.e. objects with \te\simle 2800 K. The interior of the most massive brown dwarfs is shown to develop a conductive core after $\sim 2$ Gyr which slows down their cooling. Comparison is made in optical and infrared color-magnitude diagrams with recent late-M and L-dwarf observations. The saturation in optical colors and the very red near-infrared colors of these objects are well explained by the onset of dust formation in the atmosphere. Comparison of the faintest presently observed L-dwarfs with these dusty evolutionary models suggests that dynamical processes such as turbulent diffusion and gravitational settling are taking place near the photosphere. As the effective temperature decreases below \te\approx 1300-1400 K, the colors of these objects move to very blue near-infrared colors, a consequence of the ongoing methane absorption in the infrared. We suggest the possibility ofa brown dwarf dearth in $J,H,K$ color-magnitude diagrams around this temperature.Comment: 38 pages, Latex file, uses aasms4.sty, accepted for publication in Ap