41 research outputs found
The quality of education of teachers-engineers in the republic of belarus
The system of quality management of education of teachers-engineers on the basis of the environmental approach is consideredΠ Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΡΠΈΡΡΠ΅ΠΌΠ° ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΎΠ²-ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΡΠ΅Π΄ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄
ORGANIZATION OF EDUCATIONAL PROCESS BASED ON ADAPTIVE MANAGEMENT
Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π² ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ΅ Ρ ΠΎΠΏΠΎΡΠΎΠΉ Π½Π° Π°Π΄Π°ΠΏΡΠΈΠ²Π½ΠΎΠ΅ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅We consider the organization of the educational process a technical university with the support of adaptive managemen
STRUCTURE AND CONTENT ENGINEERING AND PEDAGOGICAL PERSONNEL TRAINING IN THE REPUBLIC OF BELARUS
Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ Π΄Π²ΡΡ
ΡΡΡΠΏΠ΅Π½ΡΠ°ΡΠ°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠ½ΠΎ-ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄Π»Ρ ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ-ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ ΡΡΠ΅Π΄Π½Π΅Π³ΠΎ ΡΠΏΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π² Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠ΅ ΠΠ΅Π»Π°ΡΡΡΡWe consider a two-stage system of engineering and pedagogical training for institutions of vocational and secondary special education in the Republic of Belaru
Socio-Cultural Factor in the Training of a Teacher-Engineer
Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ Π°ΡΠΏΠ΅ΠΊΡΡ ΡΠΎΡΠΈΠΎΠΊΡΠ»ΡΡΡΡΠ½ΠΎΠΉ ΡΡΠ΅ΡΡ Π² ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΏΠ΅Π΄Π°Π³ΠΎΠ³Π°-ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠ°; ΠΎΠ±ΠΎΠ±ΡΠ°ΡΡΡΡ ΠΏΡΡΠΈ ΡΠΎΡΠΈΠΎΠΊΡΠ»ΡΡΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π±ΡΠ΄ΡΡΠ΅Π³ΠΎ ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΡΡΠ°.The aspects of the socio-cultural sphere in the educational process of teacher-engineer training are considered; the ways of socio-cultural development of the future specialist are summarized
Education of Modern Specialist as a Pedagogical Category
Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΠ΅ ΠΏΠΎΠ½ΡΡΠΈΡ Β«ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½Π½ΠΎΡΡΡΒ» Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΡΡΠ°; Π°Π½Π°Π»ΠΈΠ·ΠΈΡΡΡΡΡΡ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠΈ.The article discusses the components of the concept of Β«educationΒ» in relation to a modern specialist; social characteristics and possibilities of educational practice are analyzed
Π ΠΠΠ ΠΠΠΠ’ΠΠ ΠΠ ΠΠΠ ΠΠΠΠΠΠΠ ΠΠΠΠ£ΠΠ― ΠΠΠ― Π ΠΠ‘Π§EΠ’Π Π‘ΠΠΠ ΠΠ‘Π’Π ΠΠ‘ΠΠΠΠΠΠΠ― Π’ΠΠ’ΠΠΠΠΠΠ ΠΠΠΠΠΠ« Π Π‘Π ΠΠΠ Π’ΠΠ₯ΠΠΠΠΠΠΠ§ΠΠ‘ΠΠΠΠ ΠΠΠΠ
The program module has been developed on the basis of package of applied MATLAB programs which allows to calculate speed of coating sedimentation over the section of plasma stream taking into account magnetic field influence of a stabilizing coil, and also to correct the obtained value of sedimentation speed depending on the value of negative accelerating potential, arch current, technological gas pressure. The program resolves visualization of calculation results.Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΡΠΉ ΠΌΠΎΠ΄ΡΠ»Ρ Π½Π° Π±Π°Π·Π΅ ΠΏΠ°ΠΊΠ΅ΡΠ° ΠΏΡΠΈΠΊΠ»Π°Π΄Π½ΡΡ
ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌ MATLAB, ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ°ΡΡΡΠΈΡΠ°ΡΡ ΡΠΊΠΎΡΠΎΡΡΡ ΠΎΡΠ°ΠΆΠ΄Π΅Π½ΠΈΡ ΠΏΠΎΠΊΡΡΡΠΈΠΉ ΠΏΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΠ»Π°Π·ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΡΠΎΠΊΠ° Ρ ΡΡΠ΅ΡΠΎΠΌ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·ΠΈΡΡΡΡΠ΅ΠΉ ΠΊΠ°ΡΡΡΠΊΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°ΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ Π²Π΅Π»ΠΈΡΠΈΠ½Ρ ΡΠΊΠΎΡΠΎΡΡΠΈ ΠΎΡΠ°ΠΆΠ΄Π΅Π½ΠΈΡ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠΊΠΎΡΡΡΡΠ΅Π³ΠΎ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π°, ΡΠΎΠΊΠ° Π΄ΡΠ³ΠΈ, Π΄Π°Π²Π»Π΅Π½ΠΈΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π³Π°Π·Π°. ΠΡΠΎΠ³ΡΠ°ΠΌΠΌΠ° ΡΠ°Π·ΡΠ΅ΡΠ°Π΅Ρ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠ°ΡΡΠ΅ΡΠΎΠ²
Associations of CYP2D6, ABCB1 2677G>T/A and 3435C>T with effectiveness and safety of pharmacotherapy for acute psychotic episodes in adolescents over 28 days
Introduction. Pharmacokinetic genetic factors are prognostically relevant when prescribing antipsychotics to adult patients. Currently, there is a dearth of research on adolescents with an acute psychotic episode. Aim. To identify possible associations of CYP2D6, CYP3A4/5 and ABCB1 gene polymorphic variants with the efficacy and safety of pharmacotherapy in adolescents with an acute psychotic episode within 28 days. Materials and methods. The study included 68 adolescents with an established diagnosis of acute polymorphic psychotic disorder at the time of admission (F23.0-9 according to ICD- 10). All patients received an antipsychotic as their main therapy. Patients were monitored for 28 days. The effectiveness of antipsychotics was assessed using the Childrenβs Global Assessment Scale (CGAS), Positive and Negative Symptoms Scale (PANSS), Clinical Global Impression Severity (CGI-S) and Improvement (CGI-I). The safety of pharmacotherapy was assessed using the UKU Side Effects Rating Scale (UKU SERS), Sympson-Angus Scale (SAS), Barnes Akathisia rating scale (BARS). From each patient we obtained a buccal scraped epithelium, extracted DNA from it by sorbent method and detected carriage of genetic polymorphisms CYP3A4*22 (rs2740574), CYP3A5*3 (6986A>G, rs776746), CYP2D6*4, *9, *10 (rs3892097, rs4986774, rs1065852), ABCB1 1236C>T (rs1128503), 2677G>T/A (rs2032582), 3435C>T (rs1045642) by real-time PCR. Results. Carriers of ABCB1 2677G>T/A significantly less frequently demonstrated response to pharmacotherapy according to PANSS scale on day 14 compared to GG homozygotes (64.6 % vs. 94.7 %; p=0.014). Carriers of the ABCB1 3435C>T differed by a higher total UKU SERS score on day 14 compared to CC genotype carriers (9.21Β±5.95 vs. 5.1Β±4.48; p=0.037). Patients with Β«intermediateΒ» CYP2D6 metabolism were more likely to have reduced sleep duration (13.6 % vs. 0 %; p=0.031). ABCB1 2677G>T/A (51 % vs. 15.8 %; p=0.012) and 3435C>T (46.6 % vs. 10 %; p=0.039) were more frequently associated with dry mouth. ABCB1 3435C>T carriers were also more likely to have orthostatic vertigo (34.5 % vs. 0 %; p=0.028). Conclusion. Carriage of the ABCB1 3435C>T was associated with greater efficacy of pharmacotherapy for acute psychotic episode in adolescents after 28 days, but also increases the risk of adverse reactions in the first 2 weeks of treatment. The ABCB1 2677G>T/A was associated with an increased risk of adverse reactions as well as less reduction of psychotic symptoms on day 14 of pharmacotherapy
Analysis of associations between pharmacodynamic genetic factors and antipsychoticsβ effectiveness and safety in adolescents with acute psychotic episodes taking antipsychotics during a 28-day follow-up
Introduction. Antipsychotics are the main drugs for treatment of schizophrenia spectrum disorders. Pharmacodynamic genetic factors are being actively studied to improve the accuracy of antipsychotic selection based on pharmacogenetic testing. Purpose of this study: to establish associations of genetic polymorphisms of the DRD2, DRD3, DRD4, HTR2A, COMT, ZNF804A, and ANKS1B genes with the efficacy and safety of antipsychotics in adolescents with an acute psychotic episode during a 28-day follow-up. Materials and methods. The study included 68 adolescents with an established diagnosis of acute polymorphic psychotic disorder at the time of admission (F23.0-9 according to ICD-10). All patients received an antipsychotic as their main therapy. Patients were monitored for 28 days. The effectiveness of antipsychotics was assessed using the Childrenβs Global Assessment Scale (CGAS), Positive and Negative Symptoms Scale (PANSS), Clinical Global Impression Severity (CGI-S) and Improvement (CGI-I). The safety of pharmacotherapy was assessed using the UKU Side Effects Rating Scale (UKU SERS), Sympson-Angus Scale (SAS), Barnes Akathisia rating scale (BARS). From each patient we obtained a buccal scraped epithelium, extracted DNA from it by sorbent method and detected carriage of genetic polymorphisms DRD2 rs1800497 (C>T), DRD3 rs6280 (C>T), DRD3 rs324026 (C>T), DRD4 rs1800955 (C>T), HTR2A rs6313 (T>C), COMT rs4680 (Val158Met, G>A), ZNF804A rs1344706 (A>C), ANKS1B rs7968606 (C>T) by real-time PCR. Results. DRD2 rs1800497 T allele carriers had a stronger reduction in the PANSS subscore Β«Productive SymptomaticsΒ» on day 14 (Me=-7.0 [-9.0;-5.0] vs Me=-7.0 [-8.0;-2.0]; p=0.018) and day 28 of follow-up (Me=-11.0 [-9.0;-5.5] vs Me=-8.0 [-8.0;-2.0]; p=0.019). Also, greater improvement on the CGAS scale on day 14 of follow-up was seen in TC+CC HTR2A rs6313 carriers (Me=2.0 [1.0;3.0] vs. Me=2.0 [1.0;2.0]; p=0.029). DRD3 rs324026 homozygous carriers (TT) had a significantly lower SAS score (Me=0.5 [0.0; 1.0] vs. Me=1.0 [0.0; 5.0]; p=0.016) and UKU subscore Β«Neurological DisordersΒ» on 28 days of antipsychotic therapy (Me=0.0 [0.0; 0.0] vs. Me=1.0 [0.0; 3.8]; p=0.005). DRD3 rs324026 TT carriers also had lower severity of akathisia according to the BARS scale. Carriers of the T DRD4 rs1800955 allele had a higher SAS scale score on day 28 of therapy compared with CC homozygotes (Me=1.0 [0.0;4.0] vs Me=0.0 [0.0;1.0]; p=0.036). Conclusion. The DRD2 rs1800497 was a predictor of better reduction of productive symptoms; HTR2A rs6313 demonstrated a similar association. The DRD2 rs1800497 polymorphic variant was a predictor of better reduction of productive symptomatology; HTR2A rs6313 demonstrated a similar association. DRD3 rs324026 and HTR2A rs6313 were associated with a lower frequency of neurological adverse reactions and akathisia. In contrast, carriers of the DRD4 rs1800955 were more prone to adverse reactions on pharmacotherapy
Π‘Π»ΡΡΠ°ΠΉ ΡΡΠΆΠ΅Π»ΠΎΠ³ΠΎ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΎΡΡΡΠΎΠΉ Π΄ΠΈΠ·Π΅Π½ΡΠ΅ΡΠΈΠΈ Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ
No doubts that shigellosis severity directly depends on the spread of the gut specific lesion. There are some data published on the basis of autopsy records and pointing to shigella caused lesion spreading both to colon and ileum in adult cases especially in those older than 60 y.o. or with any immunosuppressive premorbid background. Obviously, the gut mucosa condition determines the local resistance potential and moreover it's shown that in shigellosis cases, the histologic pattern of gut mucosa depends on quantity and quality of neutrophils, extremely important to control the intensity of agent invasion. Viral infections with concomitant neutropenia are commonly considered as immune suppressive conditions. As to Herpes virus infection, it's well known as the large mucosa lesion disease that can subsequently lead to aggravation of any forthcoming acute bacterial infection. The paper suggests the description of shigellosis case confirmed with the use of PCR test (PCR kit Amplisens All-bacto-screen-FL Lab, Interlabservice) and developed by young woman with unfavorable premorbid condition. The disease course turned to be severe and complicated by the peritonitis development. The aggravating factors in the proposed case were likely such immune modulating concurrent conditions as Herpes virus infection and pregnancy. The clinical example demonstrates that young people can develop severe complicated shigellosis course given burdened premorbid background availability.ΠΠ·Π²Π΅ΡΡΠ½ΠΎ, ΡΡΠΎ ΡΡΠΆΠ΅ΡΡΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΠΈΠ³Π΅Π»Π»Π΅Π·Π° ΠΊΠΎΡΡΠ΅Π»ΠΈΡΡΠ΅Ρ Ρ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡΡ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ°. ΠΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° Π²Π·ΡΠΎΡΠ»ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΡΠΌΠ΅ΡΡΠΈΡ
ΠΎΡ ΡΠΈΠ³Π΅Π»Π»Π΅Π·Π°, Π²ΡΡΠ²Π»ΡΡΡ ΠΏΠ°ΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ ΡΠΈΠ³Π΅Π»Π»Π΅Π·Π½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ, Π·Π°Ρ
Π²Π°ΡΡΠ²Π°ΡΡΠ΅Π³ΠΎ ΠΊΠ°ΠΊ ΡΠΎΠ»ΡΡΡΡ, ΡΠ°ΠΊ ΠΈ ΠΏΠΎΠ΄Π²Π·Π΄ΠΎΡΠ½ΡΡ ΠΊΠΈΡΠΊΡ. Π’Π°ΠΊΠΎΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΎΠΏΠΈΡΠ°Π½ΠΎ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Ρ Π»ΠΈΡ ΠΏΠΎΠΆΠΈΠ»ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° ΠΈΠ»ΠΈ Π»ΠΈΡ Ρ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΠΌ ΠΏΡΠ΅ΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΠΌ ΡΠΎΠ½ΠΎΠΌ. ΠΡΡ
ΠΎΠ΄Π½ΠΎΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΠ»ΠΈΠ·ΠΈΡΡΠΎΠΉ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΠΏΡΠ΅Π΄ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ ΠΏΠΎΠ»Π½ΠΎΡΠ΅Π½Π½ΠΎΡΡΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ, Π° Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠ°ΡΡΠΈΠ½Π° ΠΏΡΠΈ ΡΠΈΠ³Π΅Π»Π»Π΅Π·Π΅, ΠΊΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π½Π΅ Π² ΠΏΠΎΡΠ»Π΅Π΄Π½ΡΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π° ΠΊΠ°ΠΊ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ, ΡΠ°ΠΊ ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ Π²Π°ΠΆΠ½Ρ Π΄Π»Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΈΠ½Π²Π°Π·ΠΈΠΈ ΡΠΈΠ³Π΅Π»Π». ΠΠΈΡΡΡΠ½ΡΠ΅ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Ρ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ΅ΠΉΡΡ Π½Π΅ΠΉΡΡΠΎΠΏΠ΅Π½ΠΈΠ΅ΠΉ ΠΎΡΠ½ΠΎΡΡΡ, ΠΊΠ°ΠΊ ΠΈΠ·Π²Π΅ΡΡΠ½ΠΎ, ΠΊ ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΠ²Π½ΡΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΡΠΌ. Herpes-Π²ΠΈΡΡΡΠ½ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΠΊΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π΅ΡΠ΅ ΠΌΠΎΠ³ΡΡ ΠΏΠΎΡΠ°ΠΆΠ°ΡΡ ΡΠ»ΠΈΠ·ΠΈΡΡΡΠ΅ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ Π²ΡΠ΅Π³ΠΎ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°, ΡΡΠΎ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎ ΡΡΡΠΆΠ΅Π»ΡΠ΅Ρ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠ΅ΠΉΡΡ Π½Π° ΡΡΠΎΠΌ ΡΠΎΠ½Π΅ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ ΠΎΡΡΡΠΎΠΉ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ. ΠΡΠΈΠ²Π΅Π΄Π΅Π½ ΡΠ»ΡΡΠ°ΠΉ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΎΡΡΡΠΎΠ³ΠΎ ΡΠΈΠ³Π΅Π»Π»Π΅Π·Π° Π½Π° Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎΠΌ ΠΏΡΠ΅ΠΌΠΎΡΠ±ΠΈΠ΄Π½ΠΎΠΌ ΡΠΎΠ½Π΅ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈ ΠΌΠΎΠ»ΠΎΠ΄ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°. ΠΠ΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΡΠ΅Π°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π° Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° (PCR kit Amplisens All-bacto-screen-FL Lab, Interlabservice). ΠΠ°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ ΠΈΠΌΠ΅Π»ΠΎ ΡΡΠΆΠ΅Π»ΠΎΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΈ ΠΎΡΠ»ΠΎΠΆΠ½ΠΈΠ»ΠΎΡΡ ΠΏΡΠΎΠΏΠΎΡΠ½ΡΠΌ ΠΏΠ΅ΡΠΈΡΠΎΠ½ΠΈΡΠΎΠΌ. Π ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΌ ΡΠ»ΡΡΠ°Π΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΎΡΡΠ³ΠΎΡΠ°ΡΡΠΈΡ
ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΠΈΠ³Π΅Π»Π»Π΅Π·Π° ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅, Π²Π΅ΡΠΎΡΡΠ½ΠΎ, ΠΈΠΌΠ΅Π»ΠΈ ΡΠ°ΠΊΠΈΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΠΌΡΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠ΅ΠΉ, ΠΊΠ°ΠΊ Π½Π΅Π·Π°Π²Π΅ΡΡΠ΅Π½Π½Π°Ρ Herpes-Π²ΠΈΡΡΡΠ½Π°Ρ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ ΠΈ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΡ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΠ΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΡΡΠΆΠ΅Π»ΠΎΠ³ΠΎ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΠΈΠ³Π΅Π»Π»Π΅Π·Π½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Ρ Π»ΠΈΡ ΠΌΠΎΠ»ΠΎΠ΄ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΌΠΎΡΠ±ΠΈΠ΄Π½ΠΎΠ³ΠΎ ΡΠΎΠ½Π°
ΠΠΠΠΠΠΠΠΠ‘Π’Π ΠΠΠΠ£ΠΠΠ¦ΠΠ’ΠΠ₯ΠΠΠΠ§ΠΠ‘ΠΠΠΠ Π€ΠΠΠΠ’ΠΠΠΠ ΠΠΠΠΠΠ― ΠΠΠΠ’ΠΠ Π¦ΠΠ ΠΠΠ ΠΠ‘ΠΠΠΠΠΠ¬ΠΠΠ ΠΠΠΠΠΠ‘Π’Π ΠΠ Π ΠΠΠΠ’ΠΠ ΠΠΠΠ¬ΠΠ«Π₯ ΠΠΠΠΠΠ«Π₯ ΠΠΠΠΠΠΠΠ’ΠΠ₯ Π£ ΠΠΠ’ΠΠ
Comparative dynamic clinical and immunomorphologicalΒ researches of childrenβs cerebrospinal fluidΒ were made during bacterial purulent meningitis (caused byΒ Neisseria meningitis, Streptococcus pneumoniae, HaemophilusΒ influenza). Regularities connected with presence ofΒ CD3 lymphocytes were discovered. They depended on etiologyΒ and phase of disease. Children with meningococcalΒ meningitis, pneumococcal meningitis or hemophilic meningitisΒ had different levels of CD3 lymphocytes in cerebrospinalΒ fluid while different phases of disease.ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅Β ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΈΠΌΠΌΡΠ½ΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ΅ΡΠ΅Π±ΡΠΎΡΠΏΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ, Π±ΠΎΠ»ΡΠ½ΡΡ
Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ Π³Π½ΠΎΠΉΠ½ΡΠΌΠΈ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΡΠ°ΠΌΠΈ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ, Π³Π΅ΠΌΠΎΡΠΈΠ»ΡΠ½ΠΎΠΉ ΠΈ ΠΏΠ½Π΅Π²ΠΌΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΡΡΠ²Π»Π΅Π½Ρ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ CD3-ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΡΡ
Β Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² Π² ΡΠΎΡΡΠ°Π²Π΅ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΊΡΡΡΠ΄Π°ΡΠ° ΡΠ΅ΡΠ΅Π±ΡΠΎΡΠΏΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈΒ ΠΊΠ°ΠΊ Π² Π΄Π΅Π±ΡΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΡΠ°ΠΊ ΠΈ ΠΏΡΠΈ Π΅Π΅ ΡΠ°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ.Β ΠΠΎΠΊΠ°Π·Π°Π½ ΡΠ°Π·Π½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ CD3-ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΡΡ
Β Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² Π² ΡΠ΅ΡΠ΅Π±ΡΠΎΡΠΏΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ,Β Π±ΠΎΠ»ΡΠ½ΡΡ
Π³Π½ΠΎΠΉΠ½ΡΠΌΠΈ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΡΠ°ΠΌΠΈ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ, Π³Π΅ΠΌΠΎΡΠΈΠ»ΡΠ½ΠΎΠΉ ΠΈ ΠΏΠ½Π΅Π²ΠΌΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΊΠ°ΠΊ Π² Π΄Π΅Π±ΡΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΡΠ°ΠΊ ΠΈ Π² ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ ΡΠ°Π½Π½Π΅ΠΉΒ ΡΠ΅ΠΊΠΎΠ½Π²Π°Π»Π΅ΡΡΠ΅Π½ΡΠΈΠΈ