Detection of an iron K Emission Line from the LINER NGC 4579

We present the results of an ASCA observation of the LINER NGC 4579. A point-like X-ray source is detected at the nucleus with a 2-10 keV luminosity of 1.5x10^41 ergs/s assuming a distance of 16.8 Mpc. The X-ray spectrum is represented by a combination of a power-law with a photon index of ~1.7 and soft thermal component with kT~0.9 keV. An iron K emission line is detected at 6.73+/-0.13 keV (rest frame) with an equivalent width of 490 +180/-190 eV and is statistically significant at more than 99.9 % confidence. The line center energy is consistent with Helium-like iron and is significantly higher than 6.4 keV which is expected from fluorescence by "cold" (or a lower ionization state of) iron. The iron line profile shows no significant red tail in contrast to Seyfert 1 galaxies although the statistics are limited. The line center energy, equivalent width, and profile are consistent with an origin in an ionized accretion disk. However the large mass accretion rate necessary to ionize the accretion disk is not consistent with the observed luminosity and normal accretion models.Comment: 15 pages, 5 figures, to appear in The Astrophysical Journa

Iron K line Variability in the Low-Luminosity AGN NGC 4579

We present results of new ASCA observations of the low-luminosity AGN (LLAGN) NGC 4579 obtained on 1998 December 18 and 28, and we report on detection of variability of an iron K emission line. The X-ray luminosities in the 2--10 keV band for the two observations are nearly identical (LX $\approx$ 2$\times10^{41}$ ergs/s), but they are $\sim$35% larger than that measured in 1995 July by Terashima et al. An Fe K emission line is detected at $6.39\pm0.09$ keV (source rest frame) which is lower than the line energy $6.73^{+0.13}_{-0.12}$ keV in the 1995 observation. If we fit the Fe lines with a blend of two Gaussians centered at 6.39 keV and 6.73 keV, the intensity of the 6.7 keV line decreases, while the intensity of the 6.4 keV line increases, within an interval of 3.5 yr. This variability rules out thermal plasmas in the host galaxy as the origin of the ionized Fe line in this LLAGN. The detection and variability of the 6.4 keV line indicates that cold matter subtends a large solid angle viewed from the nucleus and that it is located within $\sim1$ pc from the nucleus. It could be identified with an optically thick standard accretion disk. If this is the case, a standard accretion disk is present at the Eddington ratio of $L_{\rm Bol}/L_{\rm Eddington} \sim 2\times10^{-3}$. A broad disk-line profile is not clearly seen and the structure of the innermost part of accretion disk remains unclear.Comment: 9 pages, 3 figures, To appear in the Astrophyscal Jounal Letter

The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study

We have described a novel C-to-T mutation in the APP gene that corresponds to an alanine to valine substitution at position 673 in APP (A673V), or position 2 of the amyloid-\uce\ub2 (A\uce\ub2) sequence. This mutation is associated with the early onset of AD-type dementia in homozygous individuals, whereas it has a protective effect in the heterozygous state. Correspondingly, we observed differences in the aggregation properties of the wild-type and mutated A\uce\ub2 peptides and their mixture. We have carried out neutron diffraction (ND) and x-ray diffraction (XRD) experiments on magnetically-oriented fibers of A\uce\ub21-28WT and its variant A\uce\ub21-28A2V. The orientation propensity was higher for A\uce\ub21-28A2V suggesting that it promotes the formation of fibrillar assemblies. The diffraction patterns by A\uce\ub21-28WT and A\uce\ub21-28A2V assemblies differed in shape and position of the equatorial reflections, suggesting that the two peptides adopt distinct lateral packing of the diffracting units. The diffraction patterns from a mixture of the two peptides differed from those of the single components, indicating the presence of structural interference during assembly and orientation. The lowest orientation propensity was observed for a mixture of A\uce\ub21-28WT and a short N-terminal fragment, A\uce\ub21-6A2V, which supports a role of A\uce\ub2's N-terminal domain in amyloid fibril formation

Absence of system xc⁻ on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

Background: Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points to a key role for neuroinflammation, oxidative stress, and excitotoxicity in this degenerative process. System x(c)- or the cystine/glutamate antiporter could tie these pathological mechanisms together: its activity is enhanced by reactive oxygen species and inflammatory stimuli, and its enhancement might lead to the release of toxic amounts of glutamate, thereby triggering excitotoxicity and neurodegeneration. Methods: Semi-quantitative Western blotting served to study protein expression of xCT, the specific subunit of system x(c)-, as well as of regulators of xCT transcription, in the normal appearing white matter (NAWM) of MS patients and in the CNS and spleen of mice exposed to experimental autoimmune encephalomyelitis (EAE), an accepted mouse model of MS. We next compared the clinical course of the EAE disease, the extent of demyelination, the infiltration of immune cells and microglial activation in xCT-knockout (xCT(-/-)) mice and irradiated mice reconstituted in xCT(-/-) bone marrow (BM), to their proper wild type (xCT(+/+)) controls. Results: xCT protein expression levels were upregulated in the NAWM of MS patients and in the brain, spinal cord, and spleen of EAE mice. The pathways involved in this upregulation in NAWM of MS patients remain unresolved. Compared to xCT(+/+) mice, xCT(-/-) mice were equally susceptible to EAE, whereas mice transplanted with xCT(-/-) BM, and as such only exhibiting loss of xCT in their immune cells, were less susceptible to EAE. In none of the above-described conditions, demyelination, microglial activation, or infiltration of immune cells were affected. Conclusions: Our findings demonstrate enhancement of xCT protein expression in MS pathology and suggest that system x(c)- on immune cells invading the CNS participates to EAE. Since a total loss of system x(c)- had no net beneficial effects, these results have important implications for targeting system x(c)- for treatment of MS

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216