47 research outputs found
Active Flow Control Using High-Frequency Compliant Structures
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76783/1/AIAA-111-490.pd
Experimental Studies of Spectral Portraits of Propeller-driven Fixed-wing and Turbojet Aircraft in a Surveillance Radar with a Continuous Probing Signal
Statistical Model of the Combined Portrait of a Targetin Radars with Multifrequency Radiation and Complete Polarizing Reception
Air Traffic Management as a Vital Part of Urban Air Mobility—A Review of DLR’s Research Work from 1995 to 2022
Urban air mobility is a rapidly growing field of research. While drones or unmanned aerial vehicles have been operated mainly in the private and military sector in the past, an increasing range of opportunities is opening up for commercial applications. A new multitude of passenger-carrying drone or air taxi concepts promises to fulfill the dream of flying above congested urban areas. While early research has been focusing on vehicle development, solutions for urban air traffic management are lagging behind. This paper collects and reviews the main findings of past urban-air-mobility-related research projects at the German Aerospace Center (DLR) to serve as a basis for ongoing research from an air traffic management perspective
Coral assemblages, biofacies, and ecological zones in the mid‐Holocene reef deDosits of the Enriquillo Valley, Dominican Republic
A novel loss-of-function mutation in Npr2 clarifies primary role in female reproduction and reveals a potential therapy for acromesomelic dysplasia, Maroteaux type
We discovered a new spontaneous mutant allele of Npr2 named peewee (pwe) that exhibits severe disproportionate dwarfism and female infertility. The pwe phenotype is caused by a four base-pair deletion in exon 3 that generates a premature stop codon at codon 313 (L313X). The Npr2(pwe/pwe) mouse is a model for the human skeletal dysplasia acromesomelic dysplasia, Maroteaux type (AMDM). We conducted a thorough analysis of the female reproductive tract and report that the primary cause of Npr2(pwe/pwe) female infertility is premature oocyte meiotic resumption, while the pituitary and uterus appear to be normal. Npr2 is expressed in chondrocytes and osteoblasts. We determined that the loss of Npr2 causes a reduction in the hypertrophic and proliferative zones of the growth plate, but mineralization of skeletal elements is normal. Mutant tibiae have increased levels of the activated form of ERK1/2, consistent with the idea that natriuretic peptide receptor type 2 (NPR2) signaling inhibits the activation of the MEK/ERK mitogen activated protein kinase pathway. Treatment of fetal tibiae explants with mitogen activated protein kinase 1 and 2 inhibitors U0126 and PD325901 rescues the Npr2(pwe/pwe) growth defect, providing a promising foundation for skeletal dysplasia therapeutics